Temporal Sequence Learning in the cortex
皮层的时间序列学习
基本信息
- 批准号:9093135
- 负责人:
- 金额:$ 24.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-30 至 2018-08-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAnimalsBehaviorBehavioralBehavioral ParadigmBrain DiseasesCalciumCerebral cortexCodeCognitiveCollaborationsDataElementsExhibitsFeedbackGoalsHeadHumanImageLeadLearningLiteratureMeasurementMedicalMemoryMicroscopeModificationMotor CortexMotor PathwaysMusNeocortexNeuronsPatternPerceptionPopulationProcessProductionRampRecording of previous eventsRetinaRetinal Ganglion CellsRewardsSensoryShapesSpeechStereotypingStimulusStreamTimeTrainingVisualVisual CortexWaterWorkarea striataawakebehavior measurementcohortexecutive functionfluorescence imaginginsightinterestnovelorientation selectivitypublic health relevancerelating to nervous systemresearch studyresponsesequence learningspeech recognitiontwo-photonvisual stimulus
项目摘要
DESCRIPTION (provided by applicant): The broad goals of this project are to explore adaptation and learning in response to repeated presentation of temporal sequences of visual stimuli. These studies are motivated by broader ideas about how local circuits in the neocortex may be carrying out predictive computations on their inputs. Such ideas could lead to new insights into the function of the human cerebral cortex, and hence have many possible medical and technological applications. In the proposal, we describe preliminary data taken in collaboration with the Tank lab at Princeton. We first performed behavioral experiments in which we trained mice to lick in response to a violation of a repeated temporal sequence. This behavior was robust and emerged rapidly, often on the first day of training. Next, we used two-photon imaging to record from neurons in layer 2/3 of mouse V1. We found that neurons rapidly modified their responses during repeated presentation of temporal sequences. Most of the neurons adapted rapidly to the presentation of repeated temporal sequences of oriented spatial images, reaching essentially zero baseline response in several seconds (what we call the `transient response'). Then, these same neurons generate a strong response to a novel spatial image that violates the ongoing temporal sequence. In addition, we find a small subset of neurons (roughly 2 in 100) that produce a sustained response to repeated temporal sequences. This sustained response ramped up over several cycles of the sequence. Then, on a longer time scale, it exhibited some features of learning, such as an anticipatory shift to earlier times s well as a form of pattern completion when presented with a novel image. We propose to extend our studies in two ways: 1) consolidate our behavioral measurements over a larger cohort of animals with identical shaping and training histories; 2) study how these responses change during training in animals engaged in the behavioral task.
描述(由申请人提供):该项目的总体目标是探索对视觉刺激时间序列的重复呈现的适应和学习。这些研究的动机是关于新皮质中的局部电路如何对其输入进行预测计算的更广泛的想法。这些想法可能会带来对人类大脑皮层功能的新见解,因此具有许多可能的医学和技术应用。在提案中,我们描述了与普林斯顿坦克实验室合作获取的初步数据。我们首先进行了行为实验,训练小鼠舔舐,以响应违反重复时间序列的情况。这种行为非常强烈并且迅速出现,通常在训练的第一天就出现了。接下来,我们使用双光子成像来记录小鼠 V1 2/3 层的神经元。我们发现神经元在时间序列的重复呈现过程中迅速改变了它们的反应。大多数神经元迅速适应了定向空间图像的重复时间序列的呈现,在几秒钟内达到基本上为零的基线响应(我们称之为“瞬态响应”)。然后,这些相同的神经元对违反正在进行的时间序列的新颖的空间图像产生强烈的反应。此外,我们发现一小部分神经元(大约百分之二)对重复的时间序列产生持续的反应。这种持续的响应在序列的几个周期中逐渐增强。然后,在更长的时间尺度上,它表现出了一些学习的特征,例如向早期时代的预期转变,以及在呈现新图像时的一种模式完成形式。我们建议以两种方式扩展我们的研究:1)巩固我们对具有相同塑造和训练历史的更大动物群体的行为测量; 2)研究在对从事行为任务的动物进行训练期间这些反应如何变化。
项目成果
期刊论文数量(0)
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MICHAEL J BERRY其他文献
MICHAEL J BERRY的其他文献
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Neurotechnologies for Analysis of Network Dynamics
用于网络动力学分析的神经技术
- 批准号:
8915748 - 财政年份:2014
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$ 24.3万 - 项目类别:
Neurotechnologies for Analysis of Network Dynamics
用于网络动力学分析的神经技术
- 批准号:
8742713 - 财政年份:2014
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$ 24.3万 - 项目类别:
STRENGTH TRAINING IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (REACT)
慢性阻塞性肺疾病患者的力量训练 (REACT)
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8167025 - 财政年份:2010
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$ 24.3万 - 项目类别:
STRENGTH TRAINING IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (REACT)
慢性阻塞性肺疾病患者的力量训练 (REACT)
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7951398 - 财政年份:2009
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$ 24.3万 - 项目类别:
2008 Sensory Coding and The Natural Environment Gordon Research Conference
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GENE POLYMORPHISMS AND INTERVENTIONS TO PREVENT DISABILITY IN COPD PATIENTS
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7607671 - 财政年份:2007
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$ 24.3万 - 项目类别:
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