Enhancing alternatives to eating in infancy

增强婴儿期饮食的替代方案

• 批准号: 9196048
• 负责人: Leonard H Epstein
• 金额: $ 58.58万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9196048
• 关键词: Adolescent; Adult; Aftercare; Age; Animal Experimentation; Attention; Behavior; Biological; Birth; Body mass index; Child; Development; Dietary intake; Disease; Eating; Energy Intake; Energy Metabolism; Environment; Equilibrium; Food; Goals; Group Meetings; Home environment; Human; Infant; Infant Development; Intervention; Laboratories; Lead; Learning; Length; Long-Term Effects; Maintenance; Measurement; Motivation; Music; Obesity; Outcome; Overweight; Parents; Phase; Pilot Projects; Placebos; Play; Preventive Intervention; Psychological reinforcement; Randomized; Randomized Controlled Trials; Research; Risk; Sampling; Self Administration; Structure; Testing; Time; Treatment Efficacy; Weight; Weight Gain; Work; arm; behavioral economics; cognitive enhancement; drug development; energy balance; environmental enrichment for laboratory animals; falls; infancy; meetings; novel strategies; obesity in children; obesity prevention; prevent; programs; prospective; reinforcer

ABSTRACT Obesity is a disorder of positive energy balance in which energy intake exceeds energy expenditure. The motivation to eat is a basic human need, which is present at birth. One factor that may lead to increased energy intake is the imbalance between the motivation to eat and the motivation to engage in other behaviors. The motivation to eat versus engaging in other behaviors can be operationalized as the relative reinforcing value of eating versus alternative behaviors. A strong motivation to eat instead of engaging in alternative behaviors has been related to increased energy intake in adults. The motivation to eat is cross-sectionally and prospectively related to obesity in children, adolescents, and adults, and cross-sectionally related to weight status in infants. Shifting the balance from high motivation to eat to increased motivation to engage in alternative behaviors can reduce energy intake, and may be protective against weight gain. We have recently shown that a structured program to enhance music engagement in infants who are strongly motivated to eat can shift their choice from food to music. The goal of this study is to expand on this preliminary research and examine long-term effects of this intervention in infants who are highly motivated to eat. We are proposing to randomize 92 healthy infants who are high in food reinforcement to a music enhancement program versus an attention placebo play date and assess changes in food/non-food reinforcement, infant energy intake, weight for length z-score, and enriched home environment, and follow the development of these infants over a 24 month period. We predict that the music program, in comparison to the control play date, will result in a shift in choice from a motivation to eat to a motivation to engage in alternatives to eating (Specific Aim 1) and thus reduce energy intake (Specific Aim 1a), lower weight for length z-score (zWFL) (Specific Aim 2), and create a more enriched home environment (Specific Aim 3) at each measurement interval. We propose that enhancing the motivation to engage in alternatives to eating represents a novel approach to obesity prevention, and these interventions are easily implemented and scalable.

抽象的 肥胖是一种能量正平衡紊乱，其中能量摄入超过能量消耗。这 进食的动机是人类的基本需求，它与生俱来。可能导致增加的因素之一 能量摄入是指进食动机与从事其他行为的动机之间的不平衡。 吃饭的动机与从事其他行为的动机可以被操作为相对强化 饮食的价值与其他行为的比较。有强烈的动机去吃东西而不是从事其他活动 行为与成年人能量摄入增加有关。进食的动机是跨部门的 与儿童、青少年和成人的肥胖前瞻性相关，并且与体重横截面相关 婴儿状态。将平衡从吃的高动力转变为参与活动的动力 其他行为可以减少能量摄入，并可能防止体重增加。我们最近有 研究表明，一个结构化的计划可以增强有强烈进食动机的婴儿的音乐参与度 可以将他们的选择从食物转向音乐。本研究的目的是扩展这一初步研究并 检查这种干预措施对进食积极性高的婴儿的长期影响。我们提议 将 92 名食物强化程度高的健康婴儿随机分配到音乐强化计划与 注意安慰剂的玩耍日期并评估食物/非食物强化、婴儿能量摄入、体重的变化 长度 z 分数和丰富的家庭环境，并跟踪这些婴儿超过 24 岁的发育情况 月期间。我们预测，与控制播放日期相比，音乐节目将导致 选择从吃的动机到从事饮食替代品的动机（具体目标 1），从而 减少能量摄入（具体目标 1a），降低身长体重 z 分数 (zWFL)（具体目标 2），并创造 每个测量间隔的家庭环境更加丰富（具体目标 3）。我们建议 增强采取替代饮食的动力代表了一种治疗肥胖的新方法 预防，而且这些干预措施易于实施且可扩展。