Maternal-Offspring Metabolics: Family Intervention Trial (MOMFIT)

母子代谢：家庭干预试验 (MOMFIT)

• 批准号: 9029344
• 负责人: ALAN M PEACEMAN
• 金额: $ 73.25万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-23 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9029344
• 关键词: Achievement; Adherence; Age; Air; American; Behavior; Behavior Therapy; Beverages; Biological Assay; Birth; Blood Glucose; Blood Pressure; Body Composition; Breast Feeding; C-Peptide; Caring; Cesarean section; Citrus Fruit; Clinical Trials; Community Health; Control Groups; Controlled Study; Counseling; Cultural Sensitivity; Diabetes Mellitus; Diet; Dietary Fiber; Discipline of obstetrics; Effectiveness; Electrocardiogram; Energy Intake; Equilibrium; Family; Fatty acid glycerol esters; Feedback; Fiber; Focus Groups; Food; Frequencies; Gestational Age; Gestational Diabetes; Goals; Guidelines; Gynecology; Health; Health Educators; Hispanics; Hour; Infant; Institute of Medicine (U.S.); Instruction; Insulin; Intake; Intervention Trial; Length; Life Style; Lipids; Measures; Metabolic; Methods; Minority; Modeling; Monitor; Mothers; Newborn Infant; Nutrient; Obesity; Outcome; Output; Overweight; Participant; Patients; Physical activity; Plethysmography; Population; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnant Women; Prevalence; Prevention Research; Primary Prevention; Proteins; Questionnaires; Randomized; Randomized Controlled Clinical Trials; Recruitment Activity; Reporting; Research; Research Infrastructure; Risk; Secondary Prevention; Severities; Sleep; Solid; Stress; Sulfoxide; Testing; Trainers Training; Umbilical Cord Blood; Urine; Weight; Weight Gain; Weight maintenance regimen; Woman; Women' s Health; adverse pregnancy outcome; behavior measurement; cardiovascular risk factor; cruciferous vegetable; energy balance; ethnic diversity; experience; fasting glucose; fruits and vegetables; gestational weight gain; improved; innovative technologies; intervention program; lifestyle intervention; low socioeconomic status; metabolic profile; metabolomics; multidisciplinary; novel strategies; obesity in children; offspring; premature; prenatal; prevent; programs; racial and ethnic; reproductive; safety testing; skills; socioeconomics; standard care; trial comparing

The prevalence of obesity has increased dramatically in the US over the last two decades, with rapidly rising and premature adverse health consequences. Women of reproductive age, especially minorities and those of low socioeconomic status, are at risk of adverse pregnancy outcomes due to excessive gestational weight gain (GWG) and this further contributes to alarming rates of childhood obesity and diabetes. Preventing excessive GWG could reduce pregnancy complications and improve long term health of women and their offspring. Weight control studies in pregnancy are emerging but most studies have emulated traditional weight control programs through diet counseling and/or increased activity with limited evidence of sustained adherence. Novel approaches are needed to limit weight gain to Institute of Medicine (IOM) goals, and to help new mothers adhere to recommended diet, physical activity and lifestyle behaviors they can model for their families. The proposed research will develop and test a new approach to primary and secondary prevention of obesity through a behaviorally adapted, nutrient-dense, energy-balanced lifestyle that can be implemented clinically, assessed objectively and sustained long term through technologically-advanced selfmonitoring methods. This randomized controlled clinical trial compares with standard care, the GWG of overweight / obese pregnant women who participate in lifestyle intervention with individualized, motivational coaching and group sessions to develop self-monitoring of recommended diet and physical activity behavior long term. Anthropometric, metabolic, diet, activity and lifestyle outcomes will be assessed prenatally and for at least 12 months post delivery. The Northwestern Department of Obstetrics and Gynecology provides care for over 12,000 ethnically diverse obstetric patients a year, many of whom participate in clinical trials, facilitated by a highly functional obstetric research infrastructure. Our multidisciplinary team, experienced in obstetrics and prevention research, propose innovative technology and enhanced self-monitoring skills to document whether new mothers can be better prepared to develop and model diet and energy-balanced lifestyle behaviors for their families and themselves and reduce and prevent obesity long term.

在过去的二十年里，美国的肥胖患病率急剧上升，而且还在迅速上升