Maternal-Offspring Metabolics: Family Intervention Trial (MOMFIT)

母子代谢：家庭干预试验 (MOMFIT)

• 批准号: 8247940
• 负责人: ALAN M PEACEMAN
• 金额: $ 76.81万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-23 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8247940
• 关键词: Achievement; Adherence; Age; Air; American; Behavior; Behavior Therapy; Beverages; Biological Assay; Birth; Blood Glucose; Blood Pressure; Body Composition; Breast Feeding; C-Peptide; Caring; Citrus Fruit; Clinical Trials; Community Health; Control Groups; Controlled Study; Counseling; Diabetes Mellitus; Diet; Dietary Fiber; Discipline of obstetrics; Effectiveness; Electrocardiogram; Energy Intake; Equilibrium; Family; Fatty acid glycerol esters; Feedback; Fiber; Focus Groups; Food; Frequencies; Gestational Age; Gestational Diabetes; Goals; Guidelines; Gynecology; Health; Health Educators; Hispanics; Hour; Infant; Institute of Medicine (U.S.); Insulin; Intake; Intervention Trial; Length; Life Style; Lipids; Measures; Metabolic; Methods; Minority; Modeling; Monitor; Mothers; Newborn Infant; Nutrient; Obesity; Outcome; Output; Overweight; Participant; Patients; Physical activity; Plethysmography; Population; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnant Women; Prevalence; Prevention Research; Primary Prevention; Proteins; Questionnaires; Randomized; Randomized Controlled Clinical Trials; Recruitment Activity; Reporting; Research; Research Infrastructure; Risk; Secondary Prevention; Severities; Sleep; Solid; Stress; Sulfoxide; Testing; Trainers Training; Umbilical Cord Blood; Urine; Weight; Weight Gain; Weight maintenance regimen; Woman; Women' s Health; behavior measurement; cardiovascular risk factor; cruciferous vegetable; energy balance; experience; fasting glucose; fruits and vegetables; improved; innovative technologies; intervention program; lifestyle intervention; low socioeconomic status; metabolomics; multidisciplinary; novel strategies; obesity in children; offspring; premature; prenatal; prevent; programs; racial and ethnic; reproductive; safety testing; skills; socioeconomics; standard care; trial comparing

DESCRIPTION (provided by applicant): The prevalence of obesity has increased dramatically in the US over the last two decades, with rapidly rising and premature adverse health consequences. Women of reproductive age, especially minorities and those of low socioeconomic status, are at risk of adverse pregnancy outcomes due to excessive gestational weight gain (GWG) and this further contributes to alarming rates of childhood obesity and diabetes. Preventing excessive GWG could reduce pregnancy complications and improve long term health of women and their offspring. Weight control studies in pregnancy are emerging but most studies have emulated traditional weight control programs through diet counseling and/or increased activity with limited evidence of sustained adherence. Novel approaches are needed to limit weight gain to Institute of Medicine (IOM) goals, and to help new-mothers adhere to recommended diet, physical activity and lifestyle behaviors they can model for their families. The proposed research will develop and test a new approach to primary and secondary prevention of obesity through a behaviorally adapted, nutrient-dense, energy-balanced lifestyle that can be implemented clinically, assessed objectively and sustained long term through technologically-advanced self-monitoring methods. This randomized controlled clinical trial compares with standard care, the GWG of overweight and obese pregnant women who participate in lifestyle intervention with individualized, motivational coaching and group sessions to develop self-monitoring of recommended diet and physical activity behavior long term. Anthropometric, metabolic, diet, activity and lifestyle outcomes will be assessed prenatally and for at least 12 months post delivery. The Northwestern Department of Obstetrics and Gynecology provides care for over 12,000 ethnically diverse obstetric patients a year, many of whom participate in clinical trials, facilitated by a highly functional obstetric research infrastructure. Our multidisciplinary team, experienced in obstetrics and prevention research, propose innovative technology and enhanced self-monitoring skills to document whether new mothers can be better prepared to develop and model diet and energy-balanced lifestyle behaviors for their families and themselves and reduce and prevent obesity long term. PUBLIC HEALTH RELEVANCE: The proposed study will advance understanding of the effectiveness of behavioral interventions aimed at controlling GWG in a large population of ethnically diverse overweight/ and obese women. Whether changes in diet and physical activity can effectively and safely be implemented during pregnancy and sustained postpartum will be explored, as well as impact on the adiposity of the offspring.

描述（由申请人提供）：在过去二十年中，肥胖症的患病率在美国急剧增加，并迅速增加和过早的不良健康后果。育龄妇女，特别是少数民族和社会经济地位低的妇女，由于妊娠期体重过度增加（GWG）而面临不良妊娠结局的风险，这进一步导致儿童肥胖和糖尿病的惊人发生率。预防过量GWG可以减少妊娠并发症，改善妇女及其后代的长期健康。怀孕期间的体重控制研究正在兴起，但大多数研究都是通过饮食咨询和/或增加活动来模仿传统的体重控制计划，但持续坚持的证据有限。需要新的方法来限制体重增加到医学研究所（IOM）的目标，并帮助新妈妈坚持推荐的饮食，体育活动和生活方式行为，他们可以为家人树立榜样。拟议的研究将开发和测试一种新的方法，通过行为适应，营养密集，能量平衡的生活方式来预防肥胖，这种生活方式可以通过技术先进的自我监测方法在临床上实施，客观评估和长期持续。这项随机对照临床试验比较了标准护理，超重和肥胖孕妇的GWG，这些孕妇参加了个性化，动机教练和小组会议的生活方式干预 养成长期自我监控推荐饮食和体力活动行为的习惯。将在产前和产后至少12个月评估人体测量、代谢、饮食、活动和生活方式结局。西北部妇产科每年为12 000多名不同种族的产科患者提供护理，其中许多人参加了临床试验，这得益于功能强大的产科研究基础设施。我们的多学科团队在产科和预防研究方面经验丰富，提出创新技术和增强的自我监测技能，以记录新妈妈是否可以更好地为家人和自己制定和建立饮食和能量平衡的生活方式行为，并长期减少和预防肥胖。 公共卫生相关性：拟议的研究将促进对行为干预措施的有效性的理解，旨在控制GWG在一个大的人口种族多样化的超重/肥胖妇女。将探索在怀孕期间和产后持续进行饮食和体力活动的改变是否可以有效和安全地实施，以及对后代肥胖的影响。