Emory Alzheimer's Disease Center

埃默里阿尔茨海默病中心

• 批准号: 9088239
• 负责人: ALLAN I LEVEY
• 金额: $ 154.76万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9088239
• 关键词: Academic Medical Centers; Address; Advocate; Affect; African American; Alleles; Alzheimer disease prevention; Alzheimer' s Disease; Amino Acid Sequence; Amyloid beta-Protein; Animal Model; Attention; Awareness; Biological Markers; Blood; Brain; Caring; Caucasians; Clinical; Clinical Data; Clinical Research; Cognitive aging; Collaborations; Communities; DNA; DNA Resequencing; Data; Development; Disease; Early Intervention; Early identification; Education; Faculty; Family Caregiver; Fostering; Funding; Gene Targeting; Genetic; Genetic Markers; Genetic Risk; Genetic study; Grant; Health; Health Professional; Individual; Individual Differences; Interdisciplinary Study; Intervention; Investigation; Knowledge; Lead; Link; Methodology; Minority Participation; Mission; Molecular Genetics; Neurosciences; Outcomes Research; Participant; Pathogenesis; Peptide Sequence Determination; Play; Prevention; Property; Proteins; Proteomics; Public Health; Recruitment Activity; Registries; Relationship-Building; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Services; Staging; Students; Translating; Translations; United States National Institutes of Health; Variant; Work; Yeast Model System; base; built environment; burden of illness; clinical practice; cohort; collaborative environment; community center; community partnership; data access; data management; effective therapy; endothelial dysfunction; genetic variant; genome wide association study; improved; innovation; interdisciplinary approach; mass spectrometer; neuropathology; next generation; novel; outreach; programs; proteogenomics; racial difference; racial diversity; research study; response; statistics; success; targeted biomarker; therapeutic target; volunteer

DESCRIPTION (provided by applicant): The Emory Alzheimer's Disease Research Center (ADRC) provides Georgia and the region with comprehensive clinical, research, and educational programs. This renewal application outlines our success in building an environment that encourages and supports innovative projects with a general theme of discovery and translation of new targets and mechanisms to enable early identification, early interventions, and ultimately prevention of AD. Given the well documented disparities in clinical research participation and burden of disease for AD in the African American community, the Emory ADRC focuses special effort to understand and address inter-individual differences in AD, ranging from ethno-racial factors to personal differences in genetic and protein variation. We benefit from generous institutional support from Emory, one of the nation's fastest growing research academic medical centers, the generous Atlanta community, and a highly collaborative team from more than 20 departments and centers. Five Cores (Administrative, Clinical, Data Management and Statistics, Neuropathology, and Outreach Recruitment and Education), coordinate activities to effectively recruit, evaluate, and engage a diverse cohort of volunteers who actively participate in a wide variety of research studies that aim to better define the trajectory from normal cognitive aging to symptomatic stages of disease. Data from the Cores are captured and stored for distribution to local researchers and for national collaborations. Our biospecimen banks include well-characterized neuropathological case materials, blood and CSF, and DNA. These valuable resources are distributed widely for a variety of approved studies of genetic, molecular, pharmacological, and pathological investigations. The ADRC educational programs reach a broad audience of students, health care professionals, and the public. Three cutting edge research projects are closely integrated with ADRC Cores: Project 1, AD Biomarkers and Endothelial Dysfunction in Caucasians and African Americans, is a longitudinal biomarker study with full integration into the ADRC Clinical Core and OREC, leveraging a unique community based Registry for Remembrance to facilitate recruitment of African Americans; Project 2, A Proteogenomic Approach to Understanding AD GWAS Results, proposes to use state-of-the art targeted gene resequencing and mass spectrometer-based protein sequencing to advance understanding of genetic risk of AD by genetic loci by linking novel gene variants at 20+ recently identified loci directly with the encoded and expressed protein variants in AD brain in an allele specific manner; Project 3, Defining the Properties of Pathogenic Aβ strains in Alzheimer's Disease, takes an interdisciplinary approach to build on pioneering work showing AD brain extracts are transmissible in animal models, by investigating how structural differences in Aβ strains from asymptomatic vs. symptomatic stages of AD vary in their seeding and propagation in yeast and animal models.

描述（由应用程序提供）：阿尔茨海默氏病研究中心（ADRC）为佐治亚州和该地区提供全面的临床，研究和教育计划。这种更新的应用概述了我们在建立一个环境方面的成功，该环境鼓励和支持创新项目，并以发现和翻译新目标和机制的一般主题，以实现早期识别，早期干预以及最终预防AD。鉴于非裔美国人社区中临床研究参与和疾病燃烧的疾病烧伤的分布，Emory ADRC专注于理解和解决AD的个体间差异，从民族种族因素到遗传和蛋白质变异的个人差异。我们受益于埃默里（Emory）的慷慨机构支持，埃默里（Emory）是美国发展最快的研究学术医疗中心之一，慷慨的亚特兰大社区，以及来自20多个部门和中心的高度合作团队。五个核心（行政，临床，数据管理和统计，神经病理学以及外展招聘和教育），协调活动，以有效招募，评估和参与多样化的志愿者队列，这些志愿者会积极参与各种研究，旨在更好地定义正常认知衰老到症状阶段的轨迹。来自核心的数据被捕获并存储，以分发给当地研究人员和国家合作。我们的生物循环库包括特征良好的神经病理病例材料，血液和CSF以及DNA。这些有价值的资源是针对各种批准的遗传，分子，药物和病理研究的研究。 ADRC教育计划吸引了广泛的学生，医疗保健专业人员和公众。三个尖端研究项目与ADRC核心密切相结合：Project 1，AD生物标志物和高加索人和非洲裔美国人的内皮功能障碍，是一项纵向生物标志物研究，并完全集成到ADRC临床核心和OREC中，利用了独特的基于社区的纪念以纪念非洲人的纪念，以设置非洲裔美国人的招聘；项目2是一种理解AD GWAS结果的蛋白质原理方法，提出了使用最先进的靶向基因重新取证和基于质谱仪的蛋白质测序，以通过将20+的新型基因型在20岁以下的新型基因座与近来的基因座联系起来，从而提高对AD的遗传风险的理解，而最近将基因座连接到了与编码和表达的蛋白质变种中的Ad Adle ear ear ealele exleele exleele exleele exleele exleele exterele exterele exterele exterele exterele exterele exterele exterele特定方式的认识;项目3，定义了阿尔茨海默氏病中致病性Aβ菌株的特性，采用了一种跨学科的方法来建立在动物模型中AD脑提取物的开创性工作，这是可以传播的，通过研究如何从非对称性VS的AB症状阶段进行AB菌株的结构差异。