Emory Alzheimer's Disease Research Center

埃默里阿尔茨海默病研究中心

• 批准号: 10673933
• 负责人: ALLAN I LEVEY
• 金额: $ 288.47万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673933
• 关键词: Academic Medical Centers; Acceleration; Action Research; Address; Advocate; Affect; African American; African American population; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Autopsy; Awareness; Biological Markers; Biological Specimen Banks; Blood; Brain; Brain imaging; Caring; Clinic; Clinical; Clinical Research; Clinical Trials; Clinical Trials Support Unit; Collaborations; Communities; Complement; DNA; Data; Data Scientist; Dedications; Dementia; Development; Disease; Disparity; Early identification; Education; Faculty; Family Caregiver; Fostering; Foundations; Funding; Genetic; Goals; Grant; Health Professional; Heterogeneity; Image; Individual; Individual Differences; Institution; Intervention; Leadership; Link; Memory; Outcome; Participant; Pathogenicity; Personal Satisfaction; Pilot Projects; Plasma; Play; Prevention; Proteins; Proteomics; Public Health; Publications; Race; Recommendation; Research; Research Activity; Research Personnel; Research Support; Resources; Risk; Risk Factors; Role; Sampling; Scientist; Special Population; Specimen; Spinal Cord; Teacher Professional Development; Training; Translating; Translational Research; Translations; Underrepresented Minority; United States National Institutes of Health; Universities; Variant; Work; base; built environment; burden of illness; caregiving; caregiving research; clinical practice; cohort; community partnership; data management; design; diversity and inclusion; education research; effective therapy; empowerment; ethnoracial; faculty mentor; healthy aging; improved; innovation; memory care; minority engagement; multidisciplinary; neuropathology; next generation; novel; outreach; programs; recruit; research study; response; success; supportive environment; symposium; therapeutic target; training opportunity

SUMMARY/ABSTRACT: OVERALL The Goizueta Alzheimer’s Disease Research Center (ADRC) at Emory University provides Georgia and the region with comprehensive clinical, research, and educational programs. This application outlines our success in building an environment that encourages and supports innovative projects with a central theme of discovery and translation of new biomarkers and pathogenic mechanisms to enable early identification, intervention, and ultimately prevention of AD and related disorders. Given the well documented disparities in clinical research participation and burden of disease for AD in the African American community, the Goizueta ADRC dedicates effort and resources to help better understand and address inter-individual differences in AD and ADRD, ranging from ethno-racial factors to individual differences in genetic and protein variation. We benefit from generous institutional support from Emory, one of the nation’s fastest growing research academic medical centers, the generous Atlanta community, and a large and highly collaborative interdisciplinary team of more than 100 faculty across Emory and local institutions. Our cores work in a concerted manner to effectively recruit, evaluate, and engage a diverse cohort of participants who actively take part in a wide variety of research studies. The addition of a Minority Engagement Core helps to further engage special populations, most notably the African American community, to help the Outreach, Recruitment and Engagement Core and Clinical Core with an ambitious goal of 50% African American participation in the UDS cohort. Our Biomarker Core provides state-of-the-art genetic, proteomic, and brain imaging analyses, complemented by an extensive biospecimen repository of well-characterized blood, CSF, and DNA samples, and a large bank of well- characterized postmortem brains and spinal cords in the Neuropathology Core. These valuable resources will continue to be distributed widely for a variety of approved studies, including research Developmental Projects and in support of local and national collaborations. Generous institutional and philanthropic support is used to seed a much larger base of innovative research. The ADRC educational programs reach a broad audience of trainees, researchers, health care professionals, and the public. New to us with this application, the Research Education Component will help formalize our longstanding dedication to the cultivation of the next generation of scientists. With a strong commitment to diversity and inclusiveness, our program benefits from the engagement of a large and multidisciplinary core of training faculty mentors from institutions throughout the greater Atlanta area. Collectively, the ADRC is poised to continue to make important contributions to the national strategy for AD treatment and prevention.

摘要/摘要：总体 埃默里大学的Goizueta阿尔茨海默氏症研究中心(ADRC)为佐治亚州和 该地区拥有全面的临床、研究和教育项目。这份申请概述了我们的成功 营造一个鼓励和支持以发现为中心的创新项目的环境 以及新的生物标志物和致病机制的翻译，以实现早期识别、干预和 最终预防阿尔茨海默病及相关疾病。考虑到临床研究中存在的有充分证据的差异 Goizueta ADRC致力于非裔美国人社区中AD的参与和疾病负担 努力和资源，以帮助更好地了解和解决AD和ADRD的个体间差异， 从种族因素到遗传和蛋白质变异的个体差异。我们受益于 来自埃默里的慷慨的机构支持，埃默里是美国增长最快的研究学术医学之一 中心，慷慨的亚特兰大社区，以及一个大型的高度协作的跨学科团队 埃默里和当地机构的100多名教职员工。我们的核心以协调的方式工作，以有效地 招募、评估和参与各种参与者，这些参与者积极参与各种 研究性研究。增加少数群体参与核心有助于进一步促进特殊人群的参与， 最值得注意的是非洲裔美国人社区，以帮助外联、征聘和参与核心和 临床核心，雄心勃勃的目标是50%的非裔美国人参与UDS队列。我们的生物标志物 CORE提供最先进的遗传、蛋白质组和脑成像分析，并辅之以广泛的 血液、脑脊液和DNA样本的生物质谱库，以及一大批完好的 以死后大脑和脊髓为特征的神经病理核心。这些宝贵的资源将 继续广泛分发，用于各种经批准的研究，包括研究开发项目 并支持地方和国家的合作。慷慨的机构和慈善支持用于 为创新研究提供更大的基础。ADRC的教育方案覆盖了广大受众 实习生、研究人员、卫生保健专业人员和公众。对于我们来说，这一应用程序是新的，研究 教育部分将有助于将我们长期致力于培养下一代的努力正规化 科学家的身份。我们对多样性和包容性的坚定承诺，使我们的计划受益于 聘请来自全国各地机构的大型多学科核心培训教师导师 大亚特兰大地区。总体而言，亚洲发展研究中心准备继续为 治疗和预防阿尔茨海默病的国家战略。