Emory Alzheimer's Disease Research Center

埃默里阿尔茨海默病研究中心

基本信息

批准号：
10673933
负责人：
ALLAN I LEVEY
金额：
$ 288.47万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10673933
关键词：
Academic Medical Centers Acceleration Action Research Address Advocate Affect African American African American population Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Area Autopsy Awareness Biological Markers Biological Specimen Banks Blood Brain Brain imaging Caring Clinic Clinical Clinical Research Clinical Trials Clinical Trials Support Unit Collaborations Communities Complement DNA Data Data Scientist Dedications Dementia Development Disease Disparity Early identification Education Faculty Family Caregiver Fostering Foundations Funding Genetic Goals Grant Health Professional Heterogeneity Image Individual Individual Differences Institution Intervention Leadership Link Memory Outcome Participant Pathogenicity Personal Satisfaction Pilot Projects Plasma Play Prevention Proteins Proteomics Public Health Publications Race Recommendation Research Research Activity Research Personnel Research Support Resources Risk Risk Factors Role Sampling Scientist Special Population Specimen Spinal Cord Teacher Professional Development Training Translating Translational Research Translations Underrepresented Minority United States National Institutes of Health Universities Variant Work base built environment burden of illness caregiving caregiving research clinical practice cohort community partnership data management design diversity and inclusion education research effective therapy empowerment ethnoracial faculty mentor healthy aging improved innovation memory care minority engagement multidisciplinary neuropathology next generation novel outreach programs recruit research study response success supportive environment symposium therapeutic target training opportunity

项目摘要

SUMMARY/ABSTRACT: OVERALL The Goizueta Alzheimer’s Disease Research Center (ADRC) at Emory University provides Georgia and the region with comprehensive clinical, research, and educational programs. This application outlines our success in building an environment that encourages and supports innovative projects with a central theme of discovery and translation of new biomarkers and pathogenic mechanisms to enable early identification, intervention, and ultimately prevention of AD and related disorders. Given the well documented disparities in clinical research participation and burden of disease for AD in the African American community, the Goizueta ADRC dedicates effort and resources to help better understand and address inter-individual differences in AD and ADRD, ranging from ethno-racial factors to individual differences in genetic and protein variation. We benefit from generous institutional support from Emory, one of the nation’s fastest growing research academic medical centers, the generous Atlanta community, and a large and highly collaborative interdisciplinary team of more than 100 faculty across Emory and local institutions. Our cores work in a concerted manner to effectively recruit, evaluate, and engage a diverse cohort of participants who actively take part in a wide variety of research studies. The addition of a Minority Engagement Core helps to further engage special populations, most notably the African American community, to help the Outreach, Recruitment and Engagement Core and Clinical Core with an ambitious goal of 50% African American participation in the UDS cohort. Our Biomarker Core provides state-of-the-art genetic, proteomic, and brain imaging analyses, complemented by an extensive biospecimen repository of well-characterized blood, CSF, and DNA samples, and a large bank of well- characterized postmortem brains and spinal cords in the Neuropathology Core. These valuable resources will continue to be distributed widely for a variety of approved studies, including research Developmental Projects and in support of local and national collaborations. Generous institutional and philanthropic support is used to seed a much larger base of innovative research. The ADRC educational programs reach a broad audience of trainees, researchers, health care professionals, and the public. New to us with this application, the Research Education Component will help formalize our longstanding dedication to the cultivation of the next generation of scientists. With a strong commitment to diversity and inclusiveness, our program benefits from the engagement of a large and multidisciplinary core of training faculty mentors from institutions throughout the greater Atlanta area. Collectively, the ADRC is poised to continue to make important contributions to the national strategy for AD treatment and prevention.

摘要/摘要：总体埃默里大学（Emory University）的Goizueta阿尔茨海默氏病研究中心（ADRC）提供了乔治亚州和佐治亚州和具有全面的临床，研究和教育计划的地区。该应用程序概述了我们的成功在建立一个鼓励和支持以发现中心主题的创新项目的环境中以及新的生物标志物和致病机制的翻译，以实现早期鉴定，干预和最终预防AD和相关疾病。鉴于临床研究中有据可查的分布在非洲裔美国社区中，疾病的参与和燃烧，goizueta adrc dedicatedes 努力和资源以更好地理解和解决广告和ADRD的个体间差异，从民族种族因素到遗传和蛋白质变异的个体差异范围。我们从中受益埃默里（Emory）的慷慨机构支持，埃默里（Emory）是美国发展最快的研究学术医学之一中心，慷慨的亚特兰大社区，以及一个大型，高度协作的跨学科团队埃默里和地方机构的100名教职员工。我们的核心以协同的方式有效地工作招募，评估和参与潜水员队列，他们积极参加各种各样的参与者研究。增加少数派参与核心有助于进一步参与特殊人群，最值得注意的是非裔美国人社区，以帮助外展，招聘和参与核心和临床核心的目标是50％的非洲裔美国人参加UDS队列。我们的生物标志物 Core提供最先进的遗传，蛋白质组学和脑成像分析，由广泛完成特征良好的血液，CSF和DNA样本的生物循环库以及一大批良好的库存库在神经病理学核心中表征了事后大脑和脊髓。这些宝贵的资源将继续为各种批准的研究（包括研究开发项目）进行广泛分发并支持本地和国家合作。慷慨的机构和慈善支持用于播种更大的创新研究基础。 ADRC教育计划吸引了广泛的受众学员，研究人员，卫生保健专业人员和公众。通过此应用程序对我们来说是新的研究教育部分将帮助我们长期以来对下一代培养的奉献精神科学家。我们的计划对多样性和包容性做出了坚定的承诺，从在整个机构的培训教师导师的大型和多学科的核心参与大亚特兰大地区。总体而言，ADRC被中毒以继续为国家广告治疗和预防战略。