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Emory Alzheimer's Disease Research Center

埃默里阿尔茨海默病研究中心

基本信息

批准号：
10673933
负责人：
ALLAN I LEVEY
金额：
$ 288.47万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10673933
关键词：
Academic Medical Centers Acceleration Action Research Address Advocate Affect African American African American population Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Area Autopsy Awareness Biological Markers Biological Specimen Banks Blood Brain Brain imaging Caring Clinic Clinical Clinical Research Clinical Trials Clinical Trials Support Unit Collaborations Communities Complement DNA Data Data Scientist Dedications Dementia Development Disease Disparity Early identification Education Faculty Family Caregiver Fostering Foundations Funding Genetic Goals Grant Health Professional Heterogeneity Image Individual Individual Differences Institution Intervention Leadership Link Memory Outcome Participant Pathogenicity Personal Satisfaction Pilot Projects Plasma Play Prevention Proteins Proteomics Public Health Publications Race Recommendation Research Research Activity Research Personnel Research Support Resources Risk Risk Factors Role Sampling Scientist Special Population Specimen Spinal Cord Teacher Professional Development Training Translating Translational Research Translations Underrepresented Minority United States National Institutes of Health Universities Variant Work base built environment burden of illness caregiving caregiving research clinical practice cohort community partnership data management design diversity and inclusion education research effective therapy empowerment ethnoracial faculty mentor healthy aging improved innovation memory care minority engagement multidisciplinary neuropathology next generation novel outreach programs recruit research study response success supportive environment symposium therapeutic target training opportunity

项目摘要

SUMMARY/ABSTRACT: OVERALL The Goizueta Alzheimer’s Disease Research Center (ADRC) at Emory University provides Georgia and the region with comprehensive clinical, research, and educational programs. This application outlines our success in building an environment that encourages and supports innovative projects with a central theme of discovery and translation of new biomarkers and pathogenic mechanisms to enable early identification, intervention, and ultimately prevention of AD and related disorders. Given the well documented disparities in clinical research participation and burden of disease for AD in the African American community, the Goizueta ADRC dedicates effort and resources to help better understand and address inter-individual differences in AD and ADRD, ranging from ethno-racial factors to individual differences in genetic and protein variation. We benefit from generous institutional support from Emory, one of the nation’s fastest growing research academic medical centers, the generous Atlanta community, and a large and highly collaborative interdisciplinary team of more than 100 faculty across Emory and local institutions. Our cores work in a concerted manner to effectively recruit, evaluate, and engage a diverse cohort of participants who actively take part in a wide variety of research studies. The addition of a Minority Engagement Core helps to further engage special populations, most notably the African American community, to help the Outreach, Recruitment and Engagement Core and Clinical Core with an ambitious goal of 50% African American participation in the UDS cohort. Our Biomarker Core provides state-of-the-art genetic, proteomic, and brain imaging analyses, complemented by an extensive biospecimen repository of well-characterized blood, CSF, and DNA samples, and a large bank of well- characterized postmortem brains and spinal cords in the Neuropathology Core. These valuable resources will continue to be distributed widely for a variety of approved studies, including research Developmental Projects and in support of local and national collaborations. Generous institutional and philanthropic support is used to seed a much larger base of innovative research. The ADRC educational programs reach a broad audience of trainees, researchers, health care professionals, and the public. New to us with this application, the Research Education Component will help formalize our longstanding dedication to the cultivation of the next generation of scientists. With a strong commitment to diversity and inclusiveness, our program benefits from the engagement of a large and multidisciplinary core of training faculty mentors from institutions throughout the greater Atlanta area. Collectively, the ADRC is poised to continue to make important contributions to the national strategy for AD treatment and prevention.

摘要/文摘:整体