Respiratory Diseases and Exposure to Elongated Mineral Particles in Taconite Ore

呼吸道疾病和接触铁燧岩矿石中的细长矿物颗粒

• 批准号: 8842034
• 负责人: Gurumurthy Ramachandran
• 金额: $ 41.04万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8842034
• 关键词: Respiratory; Diseases; Exposure; Elongated; Mineral

Project Summary/Abstract There is a lack of well-defined studies regarding the health effects of non-asbestiform elongated mineral particles (EMPs), and a lack of agreement on the appropriate threshold dimensions of EMPs that are health- relevant. The NIOSH Roadmap for Research relating to asbestos fibers and other EMPs (2011) identifies the taconite miners of northeastern Minnesota as a population that should be studied further with detailed exposure characterization. We aim to address the question of health effects of non-asbestiform EMPs, and also the various hypotheses regarding the appropriate dimensions of the EMPs that may be relevant to respiratory health. A previous study has collected large number of personal filter samples that have been analyzed for EMPs using NIOSH 7400/7402. All these personal samples obtained have also been archived for future use. We first propose to re-analyze these samples using ISO TEM 13794 that will provide detailed information on dimension, mineralogy, and habit, and obtain estimates of personal exposures using different dimension-based exposure metrics. Second, we will develop and validate similarly exposed groups (SEGs) based on these exposure metrics. Third, we will obtain relationships (conversion factors) between the different exposure metrics for each SEG, and apply these conversion factors to the historical data to obtain exposure histories of each SEG according to these exposure metrics. Fourth, we will use the estimated exposure histories and employment histories of each worker in the cohort to calculate their cumulative exposures according to each exposure metric. Fifth, we will estimate the risk of mesothelioma, lung cancer and prevalent non-malignant respiratory disease associated with those exposures, both by themselves and in the presence of respirable dust and silica exposures. For this purpose, a large cohort of workers has been assembled with health outcome data with increasing levels of specificity- mortality, incidence of lung cancer, indicators of respiratory morbidity - spirometry, chest X-rays, etc. that have already been collected. This information along with the exposure measurements will be used to address the question of health effects of non-asbestiform EMPs, and also the various hypotheses regarding the appropriate dimensions of the EMPs that may be relevant to respiratory health

项目摘要/摘要 缺乏关于非无生效延长矿物质的健康影响的明确的研究 颗粒（EMP），并且缺乏对健康的EMP的适当阈值维度一致 相关的。与石棉纤维和其他EMP（2011）有关的研究的NIOSH路线图确定了 明尼苏达州东北部的taconite矿工作为人口，应进一步研究 暴露表征。我们旨在解决非贝壳EMP的健康影响问题，以及 还有有关EMP适当维度的各种假设可能与 呼吸健康。先前的研究收集了大量的个人过滤样本 使用NIOSH 7400/7402分析EMP。所有获得的个人样本也已存档 未来使用。我们首先建议使用ISO TEM 13794重新分析这些样品，以提供详细的 有关维度，矿物学和习惯的信息，并使用不同 基于维度的曝光指标。其次，我们将开发和验证类似暴露的组（SEG） 基于这些暴露指标。第三，我们将在不同的不同 每个SEG的暴露指标，并将这些转换因子应用于历史数据以获得暴露 根据这些暴露指标，每个SEG的历史。第四，我们将使用估计的曝光 在队列中每个工人的历史和就业历史，以计算其累积暴露 根据每个曝光度量。第五，我们将估计间皮瘤，肺癌和流行的风险 与这些暴露相关的非恶性呼吸道疾病本身和存在 可呼吸的灰尘和二氧化硅暴露。为此，已经组装了大量工人 健康结果数据的特异性水平升高 - 死亡率，肺癌的发生率，指标 呼吸发病率 - 肺活量测定法，胸部X射线等。此信息 通过暴露测量，将用于解决非垂直状态的健康效应问题 EMP，以及有关EMP适当维度的各种假设 与呼吸健康有关