Respiratory Diseases and Exposure to Elongated Mineral Particles in Taconite Ore

项目摘要/摘要 关于非蜂窝状细长矿物质对健康的影响，缺乏明确的研究。 颗粒物(EMP)，以及对健康的EMPs的适当阈值维度缺乏一致意见- 切合实际。NIOSH关于石棉纤维和其他EMP的研究路线图(2011)确定了 明尼苏达州东北部的塔科特矿工作为一个群体应该进一步研究，并详细说明 曝光特性。我们的目标是解决非蜂窝状EMP对健康的影响问题，以及 此外，关于EMP的适当维度的各种假设可能与 呼吸健康。之前的一项研究收集了大量的个人过滤器样本，这些样本已经 已使用NIOSH 7400/7402分析EMP。所有这些获得的个人样本也都已存档 未来的用途。我们首先建议使用ISO TEM13794重新分析这些样品，它将提供详细的 关于尺寸、矿物学和习惯的信息，并使用不同的方法获得个人暴露的估计 基于维度的曝光指标。第二，我们将开发和验证相似暴露组(SEG) 基于这些暴露指标。第三，我们将获得不同变量之间的关系(换算系数 每个SEG的曝光指标，并将这些转换系数应用于历史数据以获得曝光 根据这些暴露指标，每个SEG的历史。第四，我们将使用估计的风险敞口 队列中每个工人的历史和工作历史，以计算他们的累积暴露 根据每个暴露度量值。第五，我们将估计间皮瘤、肺癌和流行的风险 与这些暴露相关的非恶性呼吸道疾病，无论是本身还是在现场 呼吸性粉尘和二氧化硅暴露。为此，已经召集了一大批工人， 具有越来越高的特异性水平的健康结果数据--死亡率、肺癌发病率、 呼吸道疾病-已收集的肺活量测定、胸部X光检查等。这条信息沿着 随着暴露的进行，测量将被用来解决非蜂窝状物质对健康的影响问题 以及关于EMP的适当维度的各种假设，这些假设可能是 与呼吸系统健康相关

Project Summary/Abstract There is a lack of well-defined studies regarding the health effects of non-asbestiform elongated mineral particles (EMPs), and a lack of agreement on the appropriate threshold dimensions of EMPs that are health- relevant. The NIOSH Roadmap for Research relating to asbestos fibers and other EMPs (2011) identifies the taconite miners of northeastern Minnesota as a population that should be studied further with detailed exposure characterization. We aim to address the question of health effects of non-asbestiform EMPs, and also the various hypotheses regarding the appropriate dimensions of the EMPs that may be relevant to respiratory health. A previous study has collected large number of personal filter samples that have been analyzed for EMPs using NIOSH 7400/7402. All these personal samples obtained have also been archived for future use. We first propose to re-analyze these samples using ISO TEM 13794 that will provide detailed information on dimension, mineralogy, and habit, and obtain estimates of personal exposures using different dimension-based exposure metrics. Second, we will develop and validate similarly exposed groups (SEGs) based on these exposure metrics. Third, we will obtain relationships (conversion factors) between the different exposure metrics for each SEG, and apply these conversion factors to the historical data to obtain exposure histories of each SEG according to these exposure metrics. Fourth, we will use the estimated exposure histories and employment histories of each worker in the cohort to calculate their cumulative exposures according to each exposure metric. Fifth, we will estimate the risk of mesothelioma, lung cancer and prevalent non-malignant respiratory disease associated with those exposures, both by themselves and in the presence of respirable dust and silica exposures. For this purpose, a large cohort of workers has been assembled with health outcome data with increasing levels of specificity- mortality, incidence of lung cancer, indicators of respiratory morbidity - spirometry, chest X-rays, etc. that have already been collected. This information along with the exposure measurements will be used to address the question of health effects of non-asbestiform EMPs, and also the various hypotheses regarding the appropriate dimensions of the EMPs that may be relevant to respiratory health