Respiratory Diseases and Exposure to Elongated Mineral Particles in Taconite Ore

呼吸道疾病和接触铁燧岩矿石中的细长矿物颗粒

• 批准号: 9381087
• 负责人: Gurumurthy Ramachandran
• 金额: $ 21.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-16 至 2018-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9381087
• 关键词: Respiratory; Diseases; Exposure; Elongated; Mineral

DESCRIPTION (provided by applicant): There is a lack of well-defined studies regarding the health effects of non-asbestiform elongated mineral particles (EMPs), and a lack of agreement on the appropriate threshold dimensions of EMPs that are health- relevant. The NIOSH Roadmap for Research relating to asbestos fibers and other EMPs (2011) identifies the taconite miners of northeastern Minnesota as a population that should be studied further with detailed exposure characterization. We aim to address the question of health effects of non-asbestiform EMPs, and also the various hypotheses regarding the appropriate dimensions of the EMPs that may be relevant to respiratory health. A previous study has collected large number of personal filter samples that have been analyzed for EMPs using NIOSH 7400/7402. All these personal samples obtained have also been archived for future use. We first propose to re-analyze these samples using ISO TEM 13794 that will provide detailed information on dimension, mineralogy, and habit, and obtain estimates of personal exposures using different dimension-based exposure metrics. Second, we will develop and validate similarly exposed groups (SEGs) based on these exposure metrics. Third, we will obtain relationships (conversion factors) between the different exposure metrics for each SEG, and apply these conversion factors to the historical data to obtain exposure histories of each SEG according to these exposure metrics. Fourth, we will use the estimated exposure histories and employment histories of each worker in the cohort to calculate their cumulative exposures according to each exposure metric. Fifth, we will estimate the risk of mesothelioma, lung cancer and prevalent non-malignant respiratory disease associated with those exposures, both by themselves and in the presence of respirable dust and silica exposures. For this purpose, a large cohort of workers has been assembled with health outcome data with increasing levels of specificity- mortality, incidence of lung cancer, indicators of respiratory morbidity - spirometry, chest X-rays, etc. that have already been collected. This information along with the exposure measurements will be used to address the question of health effects of non-asbestiform EMPs, and also the various hypotheses regarding the appropriate dimensions of the EMPs that may be relevant to respiratory health

描述(由申请人提供)：关于非蜂窝状细长矿物颗粒(EMP)对健康的影响，缺乏明确的研究，也没有就与健康相关的EMP的适当阈值维度达成一致。NIOSH关于石棉纤维和其他EMP的研究路线图(2011年)将明尼苏达州东北部的塔肯矿工确定为一个应该进一步研究的群体，并对其进行详细的暴露特征描述。我们的目标是解决非糖化的EMP对健康的影响的问题，以及关于EMP的适当维度可能与呼吸健康相关的各种假设。先前的一项研究收集了大量使用NIOSH 7400/7402对EMP进行分析的个人过滤器样本。所有这些获得的个人样本也已存档，以备将来使用。我们首先建议使用ISO TEM13794重新分析这些样本，它将提供有关尺寸、矿物学和习惯的详细信息，并使用不同的基于维度的暴露指标获得个人暴露的估计。其次，我们将基于这些暴露指标开发和验证相似暴露组(SEG)。第三，我们将获得每个SEG的不同暴露指标之间的关系(转换因子)，并将这些转换因子应用于历史数据，根据这些暴露指标获得每个SEG的暴露历史。第四，我们将使用队列中每个工人的估计暴露历史和受雇历史，根据每个暴露指标计算他们的累积暴露水平。第五，我们将评估与这些暴露相关的间皮瘤、肺癌和流行的非恶性呼吸道疾病的风险，包括它们本身以及在存在呼吸性粉尘和二氧化硅暴露的情况下。为此，已经收集了一大批工人的健康结果数据，这些数据具有越来越高的特异性--死亡率、肺癌发病率、呼吸道发病率指标--肺活量测定、胸部X光检查等。这些信息和暴露测量将被用来解决非蜂窝状EMP对健康的影响问题，以及关于EMPs适当维度的可能与呼吸健康相关的各种假设

项目成果

Reconstructing Historical Exposures to Respirable Dust and Respirable Silica in the Taconite Mining Industry for 1955-2010.

重建 1955-2010 年铁燧岩采矿业中可吸入粉尘和可吸入二氧化硅的历史暴露情况。

• DOI: 10.1093/annweh/wxab099
• 发表时间: 2022
• 期刊: Annals of work exposures and health
• 影响因子: 2.6
• 作者: Shao,Yuan;Hwang,Jooyeon;MacLehose,RichardF;Alexander,BruceH;Mandel,JeffreyH;Raynor,PeterC;Ramachandran,Gurumurthy
• 通讯作者: Ramachandran,Gurumurthy

Reconstructing historical exposures to elongate mineral particles (EMPs) in the taconite mining industry for 1955-2010.

重建 1955-2010 年铁燧岩采矿业中细长矿物颗粒 (EMP) 的历史暴露。

• DOI: 10.1080/15459624.2019.1676431
• 发表时间: 2019
• 期刊: Journal of occupational and environmental hygiene
• 影响因子: 2
• 作者: Shao,Yuan;Hwang,Jooyeon;Alexander,BruceH;Mandel,JeffreyH;MacLehose,RichardF;Ramachandran,Gurumurthy
• 通讯作者: Ramachandran,Gurumurthy

A Bayesian Approach for Determining the Relationship Between Various Elongate Mineral Particles (EMPs) Definitions.

用于确定各种细长矿物颗粒 (EMP) 定义之间关系的贝叶斯方法。

• DOI: 10.1093/annweh/wxaa074
• 发表时间: 2020
• 期刊: Annals of work exposures and health
• 影响因子: 2.6
• 作者: Shao,Yuan;MacLehose,RichardF;Lin,Lifeng;Hwang,Jooyeon;Alexander,BruceH;Mandel,JeffreyH;Ramachandran,Gurumurthy
• 通讯作者: Ramachandran,Gurumurthy