Adhesion G protein-coupled receptors in CNS development and regeneration
CNS发育和再生中的粘附G蛋白偶联受体
基本信息
- 批准号:9145803
- 负责人:
- 金额:$ 39.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-30 至 2019-08-31
- 项目状态:已结题
- 来源:
- 关键词:ADGR1 geneAdhesionsAffectAllelesAntithymoglobulinAstrocytesAxonBilateralBindingBiochemicalBiologicalBiologyBiotinylationBrainCaliberCell CycleCellsCerebral cortexCerebrumClinicalCommunicationCorpus CallosumCuprizoneDataDefectDemyelinating DiseasesDemyelinationsDevelopmentDiseaseExonsExtracellular MatrixExtracellular Matrix ProteinsFamilyFamily memberG-Protein-Coupled ReceptorsGeneticHealthHumanImageInjuryKnock-outKnockout MiceLesionLigandsMagnetic Resonance ImagingMediatingMembraneMicrogyriaModelingMolecularMultiple SclerosisMusMutationMyelinMyelin SheathNatural regenerationNervous System PhysiologyNervous system structureNeuraxisNeurogliaOligodendrogliaPatientsPhenotypePlayPropertyProteomicsRNA SplicingRoleSignal TransductionStem cellsTestingTissuesToxinTransgenic MiceTransglutaminasesUp-RegulationValidationVariantWorkastrocyte progenitorbrain malformationcell typedesignglial cell developmentin vivomyelinationnervous system developmentnervous system disordernew therapeutic targetnoveloligodendrocyte lineageoligodendrocyte precursorprecursor cellpreventreceptorremyelinationrepairedtherapeutic targetwhite matter
项目摘要
DESCRIPTION (provided by applicant): Myelin is the multilayered membrane generated by glial cells that insulates and protects axons in the vertebrate nervous system. In the central nervous system (CNS), oligodendrocytes (OLs) form the myelin sheath. The molecular mechanisms that govern oligodendrocyte development, myelination, and myelin repair are poorly understood; myelin is disrupted in many neurological diseases, and so a better understanding of OL biology has important clinical implications. The object of this proposal is to study how the adhesion G protein- coupled receptor GPR56 regulates OL development, myelination, and myelin repair. Mutations in GPR56 cause a devastating human brain malformation called bilateral frontoparietal polymicrogyria (BFPP), in which the normal cortical folds of the cerebrum are replaced by numerous small gyri. In addition to the poor formation of the cerebral cortex, white matter is also adversely affected in BFPP patients. MRI images of BFPP brains reveal signal changes indicating myelination defects. Furthermore, our preliminary studies demonstrate that: 1) GPR56 is expressed in oligodendrocyte progenitor cells (OPCs) and immature OLs; 2) disruption of Gpr56 leads to CNS myelin defects in mice; and 3) there is a novel putative ligand of GPR56 in CNS. Taken together, our data support the hypothesis that GPR56 is a previously unappreciated regulator of myelination in the CNS. This proposal is designed to test this hypothesis, thus establishing novel regulators of glial cell development and myelination. Our work is likely to enhance the understanding of the basic biology of myelination and will potentially reveal a new target for therapeutics to promote repair in myelin disease.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Xianhua Piao其他文献
Xianhua Piao的其他文献
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{{ truncateString('Xianhua Piao', 18)}}的其他基金
Adhesion G Protein-Coupled Receptors in CNS Development and Regeneration
CNS 发育和再生中的粘附 G 蛋白偶联受体
- 批准号:
10622163 - 财政年份:2022
- 资助金额:
$ 39.25万 - 项目类别:
Glial Mechanisms Of Developmental Synapse Refinement
发育突触细化的神经胶质机制
- 批准号:
10468955 - 财政年份:2018
- 资助金额:
$ 39.25万 - 项目类别:
Adhesion GPCR interactome landscaping by in vivo biotinylation proteomics
通过体内生物素化蛋白质组学进行粘附 GPCR 相互作用组景观美化
- 批准号:
9750292 - 财政年份:2018
- 资助金额:
$ 39.25万 - 项目类别:
Glial Mechanisms Of Developmental Synapse Refinement
发育突触细化的神经胶质机制
- 批准号:
10250325 - 财政年份:2018
- 资助金额:
$ 39.25万 - 项目类别:
Adhesion G Protein-Coupled Receptors in CNS Development and Regeneration
CNS 发育和再生中的粘附 G 蛋白偶联受体
- 批准号:
10618323 - 财政年份:2015
- 资助金额:
$ 39.25万 - 项目类别:
Adhesion G Protein-Coupled Receptors in CNS Development and Regeneration
CNS 发育和再生中的粘附 G 蛋白偶联受体
- 批准号:
10417182 - 财政年份:2015
- 资助金额:
$ 39.25万 - 项目类别:
Adhesion G Protein-Coupled Receptors in CNS Development and Regeneration
CNS 发育和再生中的粘附 G 蛋白偶联受体
- 批准号:
10805054 - 财政年份:2015
- 资助金额:
$ 39.25万 - 项目类别:
Adhesion G protein-coupled receptors in CNS development and regeneration
CNS发育和再生中的粘附G蛋白偶联受体
- 批准号:
9349611 - 财政年份:2015
- 资助金额:
$ 39.25万 - 项目类别:
Project 3: Microglia heterogeneity and function in interneuron development
项目 3:小胶质细胞异质性和中间神经元发育中的功能
- 批准号:
10221063 - 财政年份:2014
- 资助金额:
$ 39.25万 - 项目类别:
Project 3: Microglia heterogeneity and function in interneuron development
项目 3:小胶质细胞异质性和中间神经元发育中的功能
- 批准号:
10408735 - 财政年份:2014
- 资助金额:
$ 39.25万 - 项目类别:
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