Computational and Molecular Epidemiology Training in TB and HIV in Uganda

乌干达结核病和艾滋病毒计算和分子流行病学培训

• 批准号: 9097840
• 负责人: Christopher C. Whalen
• 金额: $ 29.77万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-24 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9097840
• 关键词: Affect; Africa; Africa South of the Sahara; Bioinformatics; Cause of Death; Collaborations; Complex; Epidemic; Epidemiology; Goals; HIV-1; Incidence; Infection; Infection prevention; Methods; Molecular; Molecular Biology; Molecular Epidemiology; Morbidity - disease rate; Mycobacterium tuberculosis; Pattern; Persons; Postdoctoral Fellow; Prevalence; Research Project Grants; Science; Scientist; Series; Social Network; Technical Expertise; Training; Training Programs; Tuberculosis; Uganda; Universities; base; co-infection; design; doctoral student; mortality; novel strategies; pre-doctoral; programs; seropositive; transmission process

 DESCRIPTION (provided by applicant): The epidemics of tuberculosis (TB) and human immunodeficiency virus type-1 (HIV) infection converge with the greatest intensity in Sub-Saharan Africa where both the incidence and the prevalence of TB increased as the HIV epidemic swept through the continent. In Africa today, TB may affect up to 30% of co-infected persons and is the leading cause of death among HIV seropositive persons. Although proper treatment of both infections may limit morbidity and mortality of the co-infection, treatment may not alter the underlying dynamics of the HIV and TB epidemics, so new approaches are needed that target transmission and prevent infection in the first place. The overall goal of the proposed training program is to build sustainable capacity at Makerere University in molecular and computational epidemiology by training Ugandan scientists in these new and emerging methods so that they may be applied to study the complex and interacting transmission dynamics of HIV and M. tuberculosis in Kampala. The program will achieve its goal by training 2 pre-doctoral students in molecular or computational epidemiology, 2 post-doctoral trainees, and 5 non-degree trainees in technical skills relating to computational epidemiology and bioinformatics. To supplement this training based at UGA, the program will put on a series of short courses in Uganda relating to network sciences and their application in Epidemiology, molecular biology and bioinformatics. The proposed training program builds on the 25 year collaboration between the Ugandans and the PD and extends the five-year collaboration between Makerere University and the University of Georgia on HIV and TB. The training will be embedded and integrated into ongoing, research projects designed to examine transmission patterns of M. tuberculosis within social networks in the context of a mature HIV epidemic. The program will be directed by Dr. Christopher Whalen, at UGA, with a co-director Dr. Moses Joloba at Makerere University.

 描述（由适用提供）：结核病的流行病（TB）和人类免疫缺陷病毒类型1（HIV）感染与撒哈拉以南非洲地区最大的强度融合，因为随着HIV流行席卷统一，TB的入射和TB的患病率都会增加。在当今的非洲，结核病可能会影响多达30％的共同感染者，并且是艾滋病毒血清阳性患者死亡的主要原因。尽管对两种感染的适当治疗都可能限制了共同感染的发病率和死亡率，但治疗可能不会改变HIV和TB流行病的潜在动力学，因此需要采用新的方法来首先目标传播和防止感染。拟议的总体目标 培训计划是通过培训乌干达科学家在这些新的和新兴的方法中培训分子和计算流行病学的可持续能力，以便将它们应用于坎帕拉的HIV和结核分枝杆菌的复杂和相互作用的传播动态。该计划将通过培训2名分子或计算流行病学的博士前学生，2名博士后学员以及5位与计算流行病学和生物信息学有关的技术技能的非学位学员。为了补充UGA的这种培训，该计划将在乌干达开设一系列与网络科学有关的简短课程及其在流行病学，分子生物学和生物信息学方面的应用。拟议的培训计划基于乌干达人与PD之间的25年合作，并扩展了Makerere大学与佐治亚大学HIV和TB之间的五年合作。该培训将嵌入并融入正在进行的研究项目中，旨在检查成熟的HIV流行的社交网络中结核分枝杆菌的传播模式。该计划将由UGA的Christopher Whalen博士与Makerere University的Moses Joloba博士指导。