Computational and Molecular Epidemiology Training in TB and HIV in Uganda

 描述（由申请人提供）：结核病（TB）和人类免疫缺陷病毒1型（HIV）感染的流行在撒哈拉以南非洲最为集中，随着HIV流行病席卷非洲大陆，结核病的发病率和流行率都有所增加。在今天的非洲，结核病可能影响多达30%的合并感染者，并且是艾滋病毒血清反应阳性者的主要死因。虽然对这两种感染的适当治疗可能会限制合并感染的发病率和死亡率，但治疗可能不会改变艾滋病毒和结核病流行的基本动态，因此需要采取新的方法，首先针对传播并预防感染。提出的总体目标 培训计划是通过培训乌干达科学家在这些新的和新兴的方法，使他们可以应用于研究艾滋病毒和M的复杂和相互作用的传播动力学，在Makerere大学建立可持续的能力在分子和计算流行病学。结核病在坎帕拉。该计划将通过培训2名分子或计算流行病学的博士前学生，2名博士后学员和5名与计算流行病学和生物信息学相关的技术技能的非学位学员来实现其目标。为了补充UGA的培训，该计划将在乌干达举办一系列关于网络科学及其在流行病学，分子生物学和生物信息学中的应用的短期课程。拟议的培训计划建立在乌干达和PD之间25年的合作基础上，并延长了Makerere大学和格鲁吉亚大学在艾滋病毒和结核病方面的五年合作。培训将嵌入并整合到正在进行的研究项目中，这些项目旨在研究M。结核病在社交网络内的成熟的艾滋病毒流行的背景下。克里斯托弗惠伦，在UGA，与联合主任博士摩西Joloba在Makerere大学。

 DESCRIPTION (provided by applicant): The epidemics of tuberculosis (TB) and human immunodeficiency virus type-1 (HIV) infection converge with the greatest intensity in Sub-Saharan Africa where both the incidence and the prevalence of TB increased as the HIV epidemic swept through the continent. In Africa today, TB may affect up to 30% of co-infected persons and is the leading cause of death among HIV seropositive persons. Although proper treatment of both infections may limit morbidity and mortality of the co-infection, treatment may not alter the underlying dynamics of the HIV and TB epidemics, so new approaches are needed that target transmission and prevent infection in the first place. The overall goal of the proposed training program is to build sustainable capacity at Makerere University in molecular and computational epidemiology by training Ugandan scientists in these new and emerging methods so that they may be applied to study the complex and interacting transmission dynamics of HIV and M. tuberculosis in Kampala. The program will achieve its goal by training 2 pre-doctoral students in molecular or computational epidemiology, 2 post-doctoral trainees, and 5 non-degree trainees in technical skills relating to computational epidemiology and bioinformatics. To supplement this training based at UGA, the program will put on a series of short courses in Uganda relating to network sciences and their application in Epidemiology, molecular biology and bioinformatics. The proposed training program builds on the 25 year collaboration between the Ugandans and the PD and extends the five-year collaboration between Makerere University and the University of Georgia on HIV and TB. The training will be embedded and integrated into ongoing, research projects designed to examine transmission patterns of M. tuberculosis within social networks in the context of a mature HIV epidemic. The program will be directed by Dr. Christopher Whalen, at UGA, with a co-director Dr. Moses Joloba at Makerere University.