Image Data Acquisition, Analysis, and Modeling Core

目标：图像数据采集、分析和建模核心将负责(1)支持 所有项目的磁共振实验设计和实施；(2)开发客观的磁共振免疫组织化学 验证方法；(3)提高数据采集效率；(4)简化后处理 程序；以及(5)参与所有MRI结果的数据解释和传播。堆芯 C将探索使用T2弛豫法、髓鞘水成像来检测和量化多发性硬化的可能性 中枢神经系统白质的病理改变。 核心服务：核心C是专门为支持本计划项目赠款的所有项目而设计的，而不是 一般目的是向社区提供服务核心单位。与这项PPG范围相关的外部研究将 将在执行委员会(克罗斯、克莱因、宋和特林考斯博士)批准后审议。它是 核心C执行所有必要任务的责任，以确保所有MRI测量的成功。 决策：在这次PPG更新的规划过程中，执行委员会成员 定期会面并讨论核心C的具体任务。因此，核心联席董事宋和金 将与所有项目和核心人员密切合作，执行拟议的MRI研究并修改IF 随着项目的进展，这是必要的。试验性执行中的任何冲突都将首先在 参与项目/核心总监和Song/Kim团队。任何未解决的冲突将通过 PPG执行委员会。数据的解释和传播将由所有相关人员进行 项目/核心人员，提交执行委员会最后批准。

Objectives: The Image Data Acquisition, Analysis, and Modeling Core will be responsible for (1) supporting the MRI experimental design and execution for all projects; (2) developing an objective MRIimmunohistochemistry validation method; (3) improving data acquisition efficiency; (4) streamlining postprocessing procedures; and (5) participating in data interpretation and dissemination of all MRI results. Core C will explore the possibility of using T2 relaxometry, myelin water imaging, to detect and quantify multiple pathologies in CNS white matter. Core Services: Core C is specifically designed to support all Projects of this program project grant, not a general purposed service core unit to the community. Outside studies relevant to the scope of this PPG will be considered after the approval of Executive Committee (Drs. Cross, Klein, Song and Trinkaus). It is the responsibility of Core C to perform all necessary tasks assuring the success of all MRI measurements. Decision-Making: During the planning of this renewal of this PPG, members of the executive committee have met and discussed regularly on specific tasks of Core C. Thus, the Core Co-directors Song and Kim will work closely with all Project and Core personnel to perform the proposed MRI studies and modify if necessary as projects progress. Any conflict in experimental execution will first be resolved between the involved Project/Core directors and Song/Kim team. Any unresolved conflict will be resolved through the PPG Executive Committee. The data interpretation and dissemination will be conducted by all involved Project/Core personnel, submitting to Executive Committee for final approval.