IGF::OT::IGF

年轻人冠状动脉风险发展（CARDIA）研究由美国国家心肺血液研究所（NHLBI）于1985年建立，旨在研究美国四个社区（阿拉巴马州伯明翰;伊利诺伊州芝加哥;明尼苏达州明尼阿波利斯和加利福尼亚州奥克兰）年轻人中心血管疾病风险的分布和演变（http：//www.cardia.dopm.uab.edu/）。最初的队列（n= 5，115）在每个社区内的年龄（18-24岁和25-30岁），性别，种族（黑人和白色）和教育程度（高中或高中以下和高中以上）亚组中选择了大约相同的参与者。在第八次检查的第30年（2015年7月1日至2016年6月30日），参与者将在48-60岁之间，此时风险因素和亚临床异常普遍存在，临床事件不断出现。CARDIA提供了解决亚临床和临床疾病的发展和进展方面的机会，这些方面在老年队列中无法解决。特别是，CARDIA为早期心血管疾病（包括白色和黑人成年人的心力衰竭）的表型提供了机会。此外，心血管疾病的危险因素也可以更新。根据既往检查的风险因素数据，CARDIA有能力研究从成年早期到中年中后期的整个轨迹风险因素及其控制如何影响心功能不全的发展和进展。

The Coronary Artery Risk Development in Young Adults (CARDIA) study was established in 1985 by the NationalHeart, Lung, and Blood Institute (NHLBI) to study the distribution and evolution of cardiovascular disease riskbeginning in young adulthood in four U.S. communities (Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland,CA) (http://www.cardia.dopm.uab.edu/). The original cohort (n=5,115) was selected to have approximately the samenumber of participants in subgroups of age (18-24 and 25-30), sex, race (black and white), and education (high schoolor less and more than high school) within each community. At Year 30 the eighth examination (July 1, 2015- June30, 2016), participants will be 48-60 years old, a time when risk factors and subclinical abnormalities are prevalentand clinical events continue to emerge. CARDIA offers the opportunity to address aspects of the development andprogression of subclinical and clinical disease that cannot be addressed in older cohorts. Specifically, CARDIA offersthe opportunity to phenotype early cardiovascular disease, including heart failure in a large cohort of white andblack adults. In addition, risk factors for cardiovascular disease can be updated. With risk factor data from previousexaminations, CARDIA has the ability to study how the entire trajectory of early adulthood to mid-to-late middle-agerisk factors and their control affects development and progression of cardiac dysfunction.