SUPPLEMENTAL FUNDING TO SUPPORT EXPANDED DNA EXTRACTION FOR A CARDIA TOPMED X01 ON DNA METHYLATION

补充资金支持 Cardia TOPMED X01 的 DNA 甲基化扩展 DNA 提取

• 批准号: 10056250
• 负责人: JAMES SHIKANY
• 金额: $ 173.7万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10056250
• 关键词: SUPPLEMENTAL; FUNDING; SUPPORT; EXPANDED; DNA

The purpose of this acquisition is to provide coordinating center support services to maximize use of data and samples amassed in CARDIA over more than 30 years to address new questions about the development and progression of clinical cardiovascular disease and related conditions. The scientific objectives are to (1) enhance statistical power to perform analyses of predictors of clinical events; (2) study the progression of risk factors to subclinical to clinical CVD; and (3) identify new risk factors or interactions among factors that inform disease pathophysiology.

此次收购的目的是提供协调中心支持服务，最大限度地利用CARDIA 30多年来积累的数据和样本，以解决有关临床心血管疾病和相关疾病的发展和进展的新问题。科学目标是：(1)提高统计能力，对临床事件的预测因素进行分析；(2)研究危险因素从亚临床到临床CVD的进展；(3)识别新的危险因素或影响疾病病理生理的因素之间的相互作用。