SUPPLEMENTAL FUNDING TO SUPPORT EXPANDED DNA EXTRACTION FOR A CARDIA TOPMED X01 ON DNA METHYLATION

此次收购的目的是提供协调中心支持服务，最大限度地利用CARDIA 30多年来积累的数据和样本，以解决有关临床心血管疾病和相关疾病发展和进展的新问题。 科学目标是（1）增强统计功效，以进行临床事件预测因子分析;（2）研究风险因素从亚临床到临床CVD的进展;（3）确定新的风险因素或告知疾病病理生理学的因素之间的相互作用。

The purpose of this acquisition is to provide coordinating center support services to maximize use of data and samples amassed in CARDIA over more than 30 years to address new questions about the development and progression of clinical cardiovascular disease and related conditions. The scientific objectives are to (1) enhance statistical power to perform analyses of predictors of clinical events; (2) study the progression of risk factors to subclinical to clinical CVD; and (3) identify new risk factors or interactions among factors that inform disease pathophysiology.