Epidemiology, Prevention, and Treatment of Influenza and Other Respiratory Infect

描述(由申请人提供)：确定马拉维疟疾高度流行和艾滋病毒高流行地区城乡高危成人和儿童中与流感(和其他呼吸道病原体)相关的严重急性呼吸道感染的性质和程度。在传播流感病毒的背景下，这项工作将重点关注1岁以下儿童、孕妇和感染艾滋病毒的成年人，他们被送往马拉维城市的一家大型中心医院(布兰太尔)和一个农村地点(Chikhwawa)。设在疟疾负担较重的齐赫瓦瓦的MLW研究机构靠近位于布兰太尔的MLW主要实验室，这为比较农村和城市以及疟疾流行人口的高和低提供了独特的机会。

DESCRIPTION (provided by applicant): To define the nature and extent of influenza (and other respiratory pathogens) associated Severe Acute Respiratory Infection (SARI) amongst urban and rural high-risk adults and children in Malawi in an area with highly endemic malaria and a high HIV prevalence. In the context of circulating influenza viruses, this work will focus SARI amongst those children under 1 year old, pregnant mothers and HIV infected adults admitted with and without malaria to a large Central Hospital in urban Malawi (Blantyre) and a rural site (Chikhwawa). The proximity of a MLW research facility based in Cikhwawa with a high malaria burden to the main MLW laboratory in Blantyre, provides a unique opportunity to make comparisons between rural and urban, and high and low malaria endemic populations.