Epidemiology, Prevention, and Treatment of Influenza and Other Respiratory Infect

描述（由申请方提供）：旨在确定疟疾高度流行和HIV高流行地区马拉维城乡高危成人和儿童中流感（和其他呼吸道病原体）相关严重急性呼吸道感染（SARI）的性质和程度。在流行性流感病毒的背景下，这项工作的重点是在马拉维城市（布兰太尔）和农村地区（Chikhwawa）的一家大型中心医院收治的1岁以下儿童、孕妇和感染艾滋病毒的成人（有疟疾和无疟疾）中进行SARI。疟疾负担重的西赫瓦瓦省的一个劳动力市场研究设施与布兰太尔的主要劳动力市场实验室很接近，这为比较农村和城市以及疟疾流行程度高和低的人群提供了一个独特的机会。

DESCRIPTION (provided by applicant): To define the nature and extent of influenza (and other respiratory pathogens) associated Severe Acute Respiratory Infection (SARI) amongst urban and rural high-risk adults and children in Malawi in an area with highly endemic malaria and a high HIV prevalence. In the context of circulating influenza viruses, this work will focus SARI amongst those children under 1 year old, pregnant mothers and HIV infected adults admitted with and without malaria to a large Central Hospital in urban Malawi (Blantyre) and a rural site (Chikhwawa). The proximity of a MLW research facility based in Cikhwawa with a high malaria burden to the main MLW laboratory in Blantyre, provides a unique opportunity to make comparisons between rural and urban, and high and low malaria endemic populations.