Paraventricular thalamic nucleus: Role of orexin and opioids in ethanol intake
丘脑室旁核:食欲素和阿片类药物在乙醇摄入中的作用
基本信息
- 批准号:9049646
- 负责人:
- 金额:$ 24.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-12-01 至 2018-04-30
- 项目状态:已结题
- 来源:
- 关键词:Advisory CommitteesAffectAgonistAlcohol consumptionAlcoholismAnimalsAnteriorAnxietyApplications GrantsAreaArousalAttentionBehaviorBehavior assessmentBehavioralBrainBrain regionCREB1 geneCell NucleusCellsChronicCollaborationsConsultDiseaseEducational workshopEmotionalEmotionsEnkephalinsEthanolEventExhibitsFacultyFundingGenetic TranscriptionGoalsGrantHeavy DrinkingHomeostasisHypothalamic structureImpairmentIn Situ HybridizationIndividualInjection of therapeutic agentInvestigationLaboratoriesLateralLearningLettersLiteratureMeasuresMediatingMentorshipMessenger RNAMethodsModelingMolecularNeurobiologyNeuronsNeuropeptidesOccupationalOpioidOutputPathway interactionsPeptidesPositioning AttributePostdoctoral FellowProcessPublicationsPublishingRattusReceptor ActivationResearchResourcesRoleScientistSignal TransductionSocietiesStructureStructure of paraventricular nucleus of thalamusTechniquesTestingThalamic structureTimeTrainingUniversitiesWorkaddictionalcohol researchalcohol use disorderalcoholism preventionanalogcareer developmentdesigndrinkingdrinking behavioremotional behaviorgraduate studenthypocretinimprovedincentive salienceinnovationknowledge basemedical schoolsmeetingsmelanin-concentrating hormonemelanin-concentrating hormone receptorneurochemistrynovelorexin 1 receptororexin Borexin B receptorpromoterreceptorresearch and developmentresearch studyskillssocial
项目摘要
PROJECT SUMMARY
Alcoholism, also known as alcohol use disorder, is a chronic debilitating disorder characterized by excessive
ingestion of alcohol and impairment in social and occupational functioning. While most investigations of brain
mechanisms mediating this disorder have studied the hypothalamus or mesolimbic regions, recent evidence
focuses attention on a relatively understudied area, the paraventricular nucleus of the thalamus (PVT), which
provides an important relay point between the homeostasisregulating hypothalamus and emotionregulating
limbic nuclei. Utilizing the intermittent access model that leads to voluntary consumption of ethanol at
pharmacologicallyrelevant levels, I plan to test the overall hypothesis that ethanol drinking stimulates the
hypothalamic neuropeptide orexin (OX) to act in the PVT, primarily at the orexin 2 rather than orexin 1 receptor
(and rather than melaninconcentrating hormone at its receptor) and specifically in the anterior rather than posterior
subregion, and that this action, in turn, increases local levels of the opioid enkephalin (ENK) to promote further
ethanol intake. With this sequence of events possibly being critically important in promoting disordered alcohol use,
I propose, in Aim 1, to investigate the neurochemical events that occur following ethanol drinking, from OX
transcription in the hypothalamus to ENK release in the anterior PVT. In Aim 2, I will examine the behavioral results
of these neurochemical changes, testing the effects of OX and ENK injection in the PVT on ethanol drinking and
emotional behaviors and the possibility that these behaviors are naturally increased by elevated endogenous
peptide levels. In Aim 3, I will then look at molecular mechanisms of this OXtoENK connection and examine the
possibility that this is necessary for promoting ethanol drinking. Collectively, by using techniques as varied as
primary neuronal culture, in situ hybridization, and behavioral assessment tests, these studies should provide
significant new information on a relatively understudied nucleus, the PVT, and its potentially major involvement
in ethanol intake. In addition to the publications that should come out of this work, which will allow me to
integrate molecular, cellular, and behavioral findings, the funding of this grant proposal will give me the
necessary training in both research and career development to attain independence as a scientist. I will
additionally take part in advanced coursework and attend seminars and workshops at The Rockefeller
University and through the TriInstitutional Collaboration Network, while participating in national society
meetings. I will receive expert mentorship from my sponsor, Dr. Sarah Leibowitz, as well as my advisory
committee which, together with the abundant resources at The Rockefeller University, will allow me to learn
new experimental methods and gain new perspectives on my research questions. Thus, in the process of
conducting innovative new research, I will gain the skills necessary to successfully transition into a position as
an independent research scientist and to make a significant contribution to the field of alcohol research.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jessica Rose Barson其他文献
Jessica Rose Barson的其他文献
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{{ truncateString('Jessica Rose Barson', 18)}}的其他基金
Mechanisms of rostrocaudal differences in accumbal kappa opioid receptor effects on ethanol drinking
伏卡帕阿片受体颈尾差异对乙醇饮酒的影响机制
- 批准号:
10210667 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Mechanisms of rostrocaudal differences in accumbal kappa opioid receptor effects on ethanol drinking
伏卡帕阿片受体颈尾差异对乙醇饮酒的影响机制
- 批准号:
10627808 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Mechanisms of rostrocaudal differences in accumbal kappa opioid receptor effects on ethanol drinking
伏卡帕阿片受体颈尾差异对乙醇饮酒的影响机制
- 批准号:
10425399 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Pituitary adenylate cyclase-activating polypeptide 27 in the paraventricular thalamus and its projections: Role in ethanol drinking
室旁丘脑中的垂体腺苷酸环化酶激活多肽 27 及其预测:在乙醇饮用中的作用
- 批准号:
10380126 - 财政年份:2020
- 资助金额:
$ 24.9万 - 项目类别:
Pituitary adenylate cyclase-activating polypeptide 27 in the paraventricular thalamus and its projections: Role in ethanol drinking
室旁丘脑中的垂体腺苷酸环化酶激活多肽 27 及其预测:在乙醇饮用中的作用
- 批准号:
10597976 - 财政年份:2020
- 资助金额:
$ 24.9万 - 项目类别:
Paraventricular thalamic nucleus: Role of orexin and opioids in ethanol intake
丘脑室旁核:食欲素和阿片类药物在乙醇摄入中的作用
- 批准号:
8585016 - 财政年份:2012
- 资助金额:
$ 24.9万 - 项目类别:
Paraventricular thalamic nucleus: Role of orexin and opioids in ethanol intake
丘脑室旁核:食欲素和阿片类药物在乙醇摄入中的作用
- 批准号:
8424767 - 财政年份:2012
- 资助金额:
$ 24.9万 - 项目类别:
Paraventricular thalamic nucleus: Role of orexin and opioids in ethanol intake
丘脑室旁核:食欲素和阿片类药物在乙醇摄入中的作用
- 批准号:
9259889 - 财政年份:2012
- 资助金额:
$ 24.9万 - 项目类别:
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