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Dissolvable Hydrogel Dressing for the Treatment of Burns

用于治疗烧伤的可溶性水凝胶敷料

基本信息

批准号：
9010534
负责人：
MARK W. GRINSTAFF
金额：
$ 39.18万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-02-01 至 2019-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9010534
关键词：
Adhesives Animal Model Animals Biocompatible Materials Body Surface Burn Trauma Burn injury Burning Pain Caring Characteristics Chemistry Clinic Clinical Clinical Trials Collection Complex Contracts Cysteine Data Data Analyses Debridement Development Devices Economics Elasticity Environment Evaluation Excision Exposure to Exudate Family Family suidae Fire - disasters Fluid Balance General Anesthesia Generations Goals Healed Hour Humidity Hydrogels Impaired wound healing In Vitro Infection Injury Knowledge Link Liquid substance Mechanics Modeling Movement Nerve Operating Rooms Operative Surgical Procedures Opioid Pain Pathology Patients Pediatric Hospitals Performance Physiological Process Property Rattus Reporting Rheology Running Safety Secondary to Secure Series Services Site Skin Specialist Sterile coverings Structure-Activity Relationship Sulfhydryl Compounds Surface Surgeon Survivors Testing Time Tissues Toxic effect Translations Trauma Wound Healing aqueous base biomaterial compatibility design disability evaporation experience healing implantation in vivo in vivo Model injured novel pain receptor prototype psychologic public health relevance research study social subcutaneous thioester wound

项目摘要

DESCRIPTION: This application describes the synthesis, characterization, and evaluation of a hydrogel dressing that dissolves and can be easily removed from the wound surface of a patient with second degree burns with no further trauma. Burns are one of the most common and devastating forms of trauma. Each year, more than 300,000 people die from fire-related burn injuries and millions suffer from burn-related disabilities and disfigurements with psychological, social, and economic effects on both the survivors and their families. Dressing removal is reported to be the time of most pain (after the burn itself) and opioids continue to be the mainstay of treatment for the burn patient. The duration of a burn dressing change in a typical injury requiring ICU/OR level care is often at least 60 minutes with induction of general anesthesia, which can extend to more than three hours depending on the case. At present, all clinically approved available dressings adhere to the wound surface so that each change of dressing leads to traumatization of newly formed tissues on the outer layer of the body's surface, delayed healing, and great personal suffering for the injured patient. The application describes a thiol- terminated dendron and a bifunctional NHS-activated PEG that react with each other to form a thioester-linked hydrogel dressing that can be subsequently dissolved by exposure of an aqueous thiol solution via a thiol- thiolester exchange mechanism. The proposed experiments will test the hypothesis that a hydrogel- based, dissolvable burn dressing will provide a barrier to infection, promote wound healing, and be easily removable on demand. Importantly, it presents preliminary data demonstrating the synthesis, characterization, and performance of a dissolvable hydrogel dressing prototype. The specific aims of this four- year application are: Aim 1: Synthesize and characterize a series of hydrogel burn dressings; Aim 2: Determine the in vitro toxicity and biocompatibility, as well as in vivo compatibility after subcutaneous implantation of the dissolvable dressing; and Aim 3: Evaluate the efficacy of the dissolvable dressing in vivo.