Dissolvable Hydrogel Dressing for the Treatment of Burns

用于治疗烧伤的可溶性水凝胶敷料

• 批准号: 9010534
• 负责人: MARK W. GRINSTAFF
• 金额: $ 39.18万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9010534
• 关键词: Adhesives; Animal Model; Animals; Biocompatible Materials; Body Surface; Burn Trauma; Burn injury; Burning Pain; Caring; Characteristics; Chemistry; Clinic; Clinical; Clinical Trials; Collection; Complex; Contracts; Cysteine; Data; Data Analyses; Debridement; Development; Devices; Economics; Elasticity; Environment; Evaluation; Excision; Exposure to; Exudate; Family; Family suidae; Fire - disasters; Fluid Balance; General Anesthesia; Generations; Goals; Healed; Hour; Humidity; Hydrogels; Impaired wound healing; In Vitro; Infection; Injury; Knowledge; Link; Liquid substance; Mechanics; Modeling; Movement; Nerve; Operating Rooms; Operative Surgical Procedures; Opioid; Pain; Pathology; Patients; Pediatric Hospitals; Performance; Physiological; Process; Property; Rattus; Reporting; Rheology; Running; Safety; Secondary to; Secure; Series; Services; Site; Skin; Specialist; Sterile coverings; Structure-Activity Relationship; Sulfhydryl Compounds; Surface; Surgeon; Survivors; Testing; Time; Tissues; Toxic effect; Translations; Trauma; Wound Healing; aqueous; base; biomaterial compatibility; design; disability; evaporation; experience; healing; implantation; in vivo; in vivo Model; injured; novel; pain receptor; prototype; psychologic; public health relevance; research study; social; subcutaneous; thioester; wound

 DESCRIPTION: This application describes the synthesis, characterization, and evaluation of a hydrogel dressing that dissolves and can be easily removed from the wound surface of a patient with second degree burns with no further trauma. Burns are one of the most common and devastating forms of trauma. Each year, more than 300,000 people die from fire-related burn injuries and millions suffer from burn-related disabilities and disfigurements with psychological, social, and economic effects on both the survivors and their families. Dressing removal is reported to be the time of most pain (after the burn itself) and opioids continue to be the mainstay of treatment for the burn patient. The duration of a burn dressing change in a typical injury requiring ICU/OR level care is often at least 60 minutes with induction of general anesthesia, which can extend to more than three hours depending on the case. At present, all clinically approved available dressings adhere to the wound surface so that each change of dressing leads to traumatization of newly formed tissues on the outer layer of the body's surface, delayed healing, and great personal suffering for the injured patient. The application describes a thiol- terminated dendron and a bifunctional NHS-activated PEG that react with each other to form a thioester-linked hydrogel dressing that can be subsequently dissolved by exposure of an aqueous thiol solution via a thiol- thiolester exchange mechanism. The proposed experiments will test the hypothesis that a hydrogel- based, dissolvable burn dressing will provide a barrier to infection, promote wound healing, and be easily removable on demand. Importantly, it presents preliminary data demonstrating the synthesis, characterization, and performance of a dissolvable hydrogel dressing prototype. The specific aims of this four- year application are: Aim 1: Synthesize and characterize a series of hydrogel burn dressings; Aim 2: Determine the in vitro toxicity and biocompatibility, as well as in vivo compatibility after subcutaneous implantation of the dissolvable dressing; and Aim 3: Evaluate the efficacy of the dissolvable dressing in vivo.

 描述：本申请描述了一种水凝胶敷料的合成、表征和评估，该敷料可溶解并可以轻松地从二度烧伤患者的伤口表面去除，而不会造成进一步的创伤。烧伤是最常见和最具破坏性的创伤形式之一。每年，超过 30 万人死于与火灾相关的烧伤，数百万人遭受与烧伤相关的残疾和毁容，对幸存者及其家人造成心理、社会和经济影响。据报道，去除敷料是最疼痛的时间（烧伤本身之后），阿片类药物仍然是烧伤患者的主要治疗方法。对于需要 ICU/OR 级别护理的典型损伤，在全身麻醉诱导下，烧伤敷料更换的持续时间通常至少为 60 分钟，根据情况可能会延长至三个多小时。目前临床上批准使用的敷料均粘附于创面，每次更换敷料都会导致体表外层新生组织受到创伤，延迟愈合，给患者带来巨大的痛苦。该申请描述了硫醇封端的树突和双功能NHS激活的PEG，它们彼此反应形成硫酯连接的水凝胶敷料，随后可以通过硫醇-硫醇酯交换机制通过暴露于硫醇水溶液来溶解该敷料。拟议的实验将检验以下假设：基于水凝胶的可溶解烧伤敷料将提供感染屏障，促进伤口愈合，并且可以根据需要轻松移除。重要的是，它提供了初步数据，证明了可溶性水凝胶敷料原型的合成、表征和性能。这项为期四年的申请的具体目标是： 目标 1：合成并表征一系列水凝胶烧伤敷料；目标2：确定可溶性敷料皮下植入后的体外毒性和生物相容性以及体内相容性；目标 3：评估可溶解敷料的体内功效。