Comprehensive Training program in Imaging Science and Informatics

影像科学和信息学综合培训计划

• 批准号: 9107456
• 负责人: Mia K Markey
• 金额: $ 15.33万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9107456
• 关键词: Image; Informatics; Science; Training Programs

DESCRIPTION (provided by applicant): The over-arching theme of this proposal is to train "comprehensive imaging scientists" in the skills necessary to identify clinically relevant problems; develop instrumentation, sensors, and contrast agents to form images appropriate for the problem; and analyze the resulting imaging data using signal processing, mathematical modeling, visualization, and informatics techniques to improve the prevention, detection, diagnosis, and treatment of human diseases. The program spans from molecular to cellular to tissue to organ. In order for imaging scientists to be knowledgeable of the full trajectory from image formation to analysis and decision-making, they must be trained in four core areas: Instrumentation, Devices, and Contrast Agents; Image processing; Modeling and Visualization; and Informatics. All students in the program are trained in the core concepts of these areas. The current training program is a two year pre-doctoral portfolio program. A total of 20 students have been admitted to the program. The proposed renewal will train another 16 students. The program includes off-campus externship research experiences and a wide-ranging professional development component. Imaging Science is an integral element of basic science research and clinical medicine. Imaging cell trafficking and receptor pharmacology in vivo have already led to targeted drug and gene therapies and an understanding of cellular biochemical pathways will contribute to new advances in medicine. Individualized medicine relies heavily on imaging techniques to select the best therapies and monitor progress. Although structural in situ human imaging is already a critical component of clinical medicine, many advances are needed in functional imaging of the brain and other organs to improve healthcare. President Obama has recently allocated $100M to research on brain mapping that relies heavily on imaging. We have identified a critical need for imaging scientists to develop new imaging instrumentation and apply that instrumentation with appropriate informatics and data mining. This training program will have a high impact on basic science and clinical medicine by providing the next generation of imaging scientists in academia, industry and national labs. This training program fills a criticl niche by providing highly skilled scientists who are trained in the broad trajectory of imaging science with a coherent training focus. This program intentionally has the breadth for our graduates to choose career pathways that require any or all aspects of imaging science. Understanding the interplay between the instrumentation and informatics is important for designing the next generation of hardware and software tools for quantifying structure and function in complex biological systems.

描述（由申请人提供）：本提案的主要主题是培训“综合成像科学家”掌握识别临床相关问题所需的技能;开发仪器、传感器和造影剂，以形成适合问题的图像;并使用信号处理、数学建模、可视化和信息学技术来分析所得到的成像数据，以改进预防、检测，诊断和治疗人类疾病。该计划涵盖从分子到细胞到组织到器官。为了使成像科学家了解从图像形成到分析和决策的完整轨迹，他们必须在四个核心领域接受培训：仪器，设备和造影剂;图像处理;建模和可视化;以及信息学。该计划的所有学生都接受了这些领域核心概念的培训。目前的培训计划是一个为期两年的博士前组合计划。共有20名学生被录取。计划中的更新将再培训16名学生。该计划包括校外实习研究经验和广泛的专业发展组成部分。影像科学是基础科学研究和临床医学不可分割的组成部分。体内成像细胞运输和受体药理学已经导致靶向药物和基因治疗，对细胞生化途径的理解将有助于医学的新进展。个体化医疗在很大程度上依赖于成像技术来选择最佳疗法和监测进展。虽然人体结构原位成像已经是临床医学的重要组成部分，但在大脑和其他器官的功能成像方面还需要取得许多进展，以改善医疗保健。奥巴马总统最近拨款1亿美元用于研究严重依赖成像的大脑图谱。我们已经确定了成像科学家开发新的成像仪器，并应用该仪器与适当的信息学和数据挖掘的关键需求。该培训计划将通过为学术界、工业界和国家实验室提供下一代成像科学家，对基础科学和临床医学产生重大影响。该培训计划填补了一个关键的利基，为在成像科学的广泛轨迹中接受过培训的高技能科学家提供连贯的培训重点。该计划有意为我们的毕业生选择需要成像科学的任何或所有方面的职业途径的广度。了解仪器和信息学之间的相互作用对于设计下一代硬件和软件工具来量化复杂生物系统的结构和功能非常重要。