Training in Clinical and Basic Neuroscience

描述(申请人提供)：这个以疾病为导向的神经科学培训项目已经资助了29年，涉及密歇根大学和VA Ann Arbor Health System的神经病学、神经外科、儿科、内科、麻醉学、急诊医学、心理学、人类遗传学、放射学、细胞与发育生物学、心血管医学、病理学和流行病学。超过35,000平方英尺的实验室空间可用于基础研究，42名教职员工担任导师，其中大多数是内科科学家。我们培训医生和基础科学家进行基础和临床疾病导向的神经科学。我们提供细胞和分子神经科学、神经化学、神经生理学、神经药理学和神经遗传学方面的基础科学和翻译科学培训。我们提供神经退行性疾病、神经肌肉疾病、睡眠障碍、中风和系统神经科学的临床科学培训。基于实验室的研究培训在很大程度上是一种传统的以项目为导向的方法，由受训教师仔细指导。临床研究培训包括临床疾病评估、临床-病理相关性、实验治疗学、解剖、分子和功能成像，以及流行病学研究。培训是在个别实验室或临床项目中进行的，但辅以跨学科和协作的项目会议、研讨会和适当的课程工作。所有临床科学项目的实习生都必须参加公共卫生学院的临床研究设计和统计分析硕士项目。受训人员包括完成临床培训并选择基础或临床研究职业的神经科医生、神经外科医生、儿科医生或其他内科医生，以及寻求接受以疾病为导向的基础神经科学培训的生物医学科学家。学员是由项目执行委员会以竞争性方式挑选出来的。这一培训计划嵌入了密歇根大学丰富的研究环境中，其中包括高度合作和跨学科的神经科学研究社区，出色的生物医学研究核心资源，以及强大的临床研究资源。后者包括非常强大的公共卫生学院，以及由我们的CTSA支持的非常强大的临床研究和指导资源。个别导师负责指导受训人员提出研究建议，监督受训人员的工作，并评估受训人员的表现，并由特定学科委员会为每名受训人员提供额外指导，并由执行委员会进行一般监督。我们之前的学员已经成功地进入了富有成效的学术生涯，我们不得不拒绝优秀的培训补助金职位申请者。我们建议将我们的实习生人数从每年4名增加到6名博士后研究员。努力招收符合条件的妇女和少数民族学生参加各级培训。

DESCRIPTION (provided by applicant): This training program in disease-oriented neuroscience has been funded for the past 29 years, and involves the Departments of Neurology, Neurosurgery, Pediatrics, Internal Medicine, Anesthesia, Emergency Medicine, Psychology, Human Genetics, Radiology, Cell & Developmental Biology, Cardiovascular Medicine, Pathology, and Epidemiology at the University of Michigan and the VA Ann Arbor Health System. More than 35,000 square feet of laboratory space are available for basic research, and 42 faculty members, most of whom are physician-scientists, serve as mentors. We train physicians and basic scientists to conduct basic and clinical disease-oriented neuroscience. We offer basic science and translational science training in cell and molecular neuroscience, neurochemistry, neurophysiology, neuropharmacology, and neurogenetics. We offer clinical science training in neurodegenerative disorders, neuromuscular diseases, sleep disorders, stroke, and systems neuroscience. Laboratory based research training is a largely a traditional project oriented approach with careful mentoring by trainee preceptors. Clinical research training involves evaluation of clinical disorders, clinical-pathological correlations, experimental therapeutics, anatomic, molecular and functional imaging, and epidemiological studies. Training is in the individual laboratory or clinical program but is supplemented by interdisciplinary and collaborative project meetings, seminars, and appropriate course work. All trainees in clinical science programs are required to enroll in the School of Public Health's Masters Program in Clinical Research Design and Statistical Analysis. Trainees are neurologists, neurosurgeons, pediatricians, or other physicians who have completed clinical training and select a basic or clinical research career, and biomedical scientists who seek training in disease-oriented basic neuroscience. Trainees are selected competitively by the program's Executive Committee. This training program is embedded within the rich research environment of the University of Michigan which includes a highly collegial and interdisciplinary neuroscience research community, excellent core resources for biomedical research, and strong resources for clinical research. The latter include a very strong School of Public Health, and very strong clinical research and mentoring resources supported by our CTSA. Individual mentors are responsible for guiding their trainees in generating research proposals, supervising trainees' work, and evaluating trainees' performance with additional mentoring provided by discipline specific committees for each trainee and general oversight by the Executive Committee. Our prior trainees have been successful in proceeding to productive academic careers and we have to turn away excellent applicants for training grant positions. We propose to increase our trainee number from 4 to 6 postdoctoral fellows per year. Efforts are made to recruit qualified women and minority students for training at all levels.