FASEB SRC on Ubiquitin & Cellular Regulation

FASEB SRC 关于泛素

• 批准号: 9124499
• 负责人: RAYMOND J DESHAIES
• 金额: $ 0.9万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-10 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9124499
• 关键词: Bacteria; Biochemical; Biochemistry; Biological Process; Biology; Biotechnology; Cell Cycle; Cells; Cellular biology; Clinical; Collaborations; Communicable Diseases; Communication; DNA Damage; Development; Disease; Ensure; Enzymes; Eukaryotic Cell; Event; Fostering; Functional disorder; Genetic Transcription; Health; Immune System Diseases; Immune system; Infectious Agent; International; Link; Malignant Neoplasms; Membrane; Metabolic Pathway; Microbe; Modification; Montana; Multiple Myeloma; Neurologic; Participant; Pathway interactions; Process; Proteasome Inhibitor; Proteins; Publications; Receptor Signaling; Research; Research Personnel; Role; Science; Scientist; Senior Scientist; Signal Transduction; System; Therapeutic Intervention; Ubiquitin; Ubiquitin Like Proteins; Ubiquitination; Universities; Virus; Virus Diseases; Washington; Whole Organism; Woman; abstracting; antigen processing; base; career; cell growth regulation; enzyme mechanism; enzyme pathway; meetings; microbial; multicatalytic endopeptidase complex; novel strategies; novel therapeutics; posters; protein degradation; protein transport; public health relevance; response; summer research; symposium; therapeutic target; willingness

 DESCRIPTION (provided by applicant): The FASEB Science Research Conference on Ubiquitin and Cellular Regulation is the premier forum for the field on the fundamental biochemistry and biological functions of the ubiquitin-proteasome system. The FASEB-sponsored conference has been held biannually since 1989; this application seeks support for the 2016 conference. Protein ubiquitination cuts across all fields of biology and the diversity of its impacts cannot be overstated. The selective degradation of proteins by the ubiquitin system is a mechanism for control of virtually all aspects of eukaryotic cell biology, including the cell cycle, transcription, metabolic pathways, development, and antigen processing. In addition, non- proteolytic functions of ubiquitination in protein trafficking and signaling are critical for proceses that involve membrane receptors and signaling in the innate immune system, while others help to coordinate the DNA damage response. Dysfunction of the system is involved in many disease processes, particularly cancer, neurologic and developmental diseases, and viral and microbial infectious diseases. In addition, ubiquitin-like proteins (also covered in this conference) are critical in infectious diseases, and it is now evident that microbes encode ubiquitin-like proteins, that bacteria and viruses produce enzymes to modulate and/or emulate cellular ubiquitination pathways in host cells, and that cells defend themselves against infectious agents with specific ubiquitin-like proteins. The 2016 conference, to be held June 12 - 17, is organized by Rachel Klevit (Univ. of Washington) and Raymond Deshaies (Cal. Tech.), both of whom have been regular participants of the conference for more than a decade. The conference will open with a keynote presentation by Dr. Vishva Dixit (Genentech, Inc.) that will highlight how fundamental discoveries in the Ub pathway are made and leveraged by biotech companies to develop new therapeutics. Nine scientific sessions, co-chaired by leaders in field will cover an array of cutting edge research that spans the range from atomic-level structural studies to whole organism studies focused on a diverse swath of biology. Twenty-seven internationally renowned speakers have been confirmed (including 10 women, 1 2 international scientists, and 14 speakers who have not spoken previously at this conference). Six additional speakers will be invited based on exciting recent developments and up to thirty short talks will be chosen from submitted abstracts. The FASEB conference brings together new investigators and leading experts on ubiquitination ensuring that the field continues to expand its scientific horizons and impact. Overall, we seek to enhance the dissemination important n e w findings in this dynamic field and to encourage open communication and collaboration to broaden the understanding of the roles of ubiquitin, the proteasome, and ubiquitin-like proteins in health and disease.

 描述（由申请人提供）：FASEB关于泛素和细胞调节的科学研究会议是泛素-蛋白酶体系统的基本生物化学和生物学功能领域的首要论坛。自1989年以来，FASEB赞助的会议每两年举行一次;此申请寻求对2016年会议的支持。蛋白质泛素化跨越生物学的所有领域，其影响的多样性怎么强调都不过分。泛素系统对蛋白质的选择性降解是一种控制真核细胞生物学几乎所有方面的机制，包括细胞周期、转录、代谢途径、发育和抗原加工。此外，蛋白质运输和信号传导中的泛素化的非蛋白水解功能对于涉及先天免疫系统中的膜受体和信号传导的过程至关重要，而其他功能有助于协调DNA损伤反应。该系统的功能障碍涉及许多疾病过程，特别是癌症、神经和发育疾病以及病毒和微生物感染性疾病。此外，泛素样蛋白（也包括在本次会议中）在感染性疾病中至关重要，现在很明显，微生物编码泛素样蛋白，细菌和病毒产生酶来调节和/或模拟宿主细胞中的细胞泛素化途径，细胞保护自己免受感染。 具有特异性泛素样蛋白的药物。2016年的会议将于6月12日至17日举行，由雷切尔·克莱维特（华盛顿大学）和雷蒙德·德沙伊斯（加州理工学院）组织，他们两人十多年来一直是会议的常客。会议将以Vishva Diplomat博士（Genentech，Inc.）这将突出如何 生物技术公司利用Ub途径的基本发现来开发新的治疗方法。由该领域领导人共同主持的九个科学会议将涵盖一系列前沿研究，涵盖从原子级结构研究到专注于生物学不同领域的整体生物研究。27位国际知名的演讲者已被确认（包括10位女性，12位国际科学家和14位以前未在本次会议上发言的演讲者）。根据令人兴奋的最新发展，将邀请另外六位演讲者，并从提交的摘要中选择多达三十个简短的演讲。FASEB会议汇集了新的研究人员和泛素化领域的领先专家，确保该领域继续扩大其科学视野和影响。总的来说，我们寻求加强在这一动态领域的重要新发现的传播，并鼓励开放的交流和合作，以扩大对泛素，蛋白酶体和泛素样蛋白在健康和疾病中的作用的理解。