2015 Apoptotic Cell Recognition & Clearance Gordon Research Conference & Gordon Research Seminar

2015年凋亡细胞识别

• 批准号: 8989275
• 负责人: DAVID S UCKER
• 金额: $ 0.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-12 至 2015-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8989275
• 关键词: Aging; Apoptosis; Apoptotic; Area; Atherosclerosis; Attention; Atypical lymphocyte; Autoimmune Diseases; Autoimmunity; Biology; Blood Platelets; Cell Death; Cells; Characteristics; Chronic; Clinical; Coagulation Process; Collaborations; Communicable Diseases; Defect; Development; Discipline; Dissection; Event; Evolution; Failure; Feedback; Fostering; Funding; Future; Homeostasis; Human; Immune; Immunosuppression; Immunosuppressive Agents; Inflammation; Inflammatory; International; Life; Link; Lipids; Lung; Malignant Neoplasms; Microbial Biofilms; Molecular; Neurodegenerative Disorders; Neurologic; New England; Organism; Participant; Pathogenesis; Pathologic Processes; Pathology; Physiological; Physiological Processes; Play; Postdoctoral Fellow; Process; Regulation; Research; Research Personnel; Rheumatoid Arthritis; Role; Scientist; Series; Shapes; Site; Staging; Students; System; Systemic Lupus Erythematosus; Therapeutic Intervention; Time; Underrepresented Minority; United States; Universities; Woman; Work; abstracting; career; career development; cell transformation; experience; graduate student; insight; meetings; microbial; neuron development; neutrophil; pathogen; peer; posters; programs; public health relevance; symposium; uptake

 DESCRIPTION (provided by applicant): Apoptosis is the primary mechanism by which nucleated cells die physiologically and is ongoing throughout life in metazoan organisms. The magnitude of apoptosis (in humans, about 1011 cells die apoptotically each day) demands an efficient system for corpse recognition and clearance. Indeed, the rapid clearance of apoptotic cells is a critical homeostatic process, representing a final step of the physiological cell death program. The clearance of apoptotic cells occurs in the absence of inflammation; indeed, apoptotic cells are potently immunosuppressive. The failure of the process of apoptotic cell clearance has been linked to chronic inflammation and autoimmunity characteristic of systemic lupus erythematosus, rheumatoid arthritis, and other pathologies including atherosclerosis. While many molecular details remain to be elucidated, the broad outlines of the process of apoptotic cell recognition and clearance have come into focus over recent years. Further, it is apparent that these mechanisms play profound roles in a broad range of distinct physiological and pathological processes, ranging from the shaping neurological networks to microbial pathogenesis. The examination these disparate settings both enlarges our appreciation of the significance of the apoptotic processes and provides unique insights that enhance molecular characterizations and foster the development of therapeutic interventions. The 2015 Apoptotic Cell Recognition and Clearance Gordon Research Conference will explore molecular details of apoptotic cell recognition and clearance mechanisms throughout evolution, including apoptotic immune regulation. Issues pertaining to the pathogenic subversion of mechanisms of apoptotic cell clearance, apoptotic cell clearance during neuronal development and in lung homeostasis, the relationship between apoptotic recognition and coagulation, and aging-associated effects on these processes also will be major foci of discussion. This conference, which is the only regular international meeting dedicated to the integrated exploration of these topics, will bring together diverse group of investigators, with expertise in varied basic and clinical disciplines, who are at the forefront of these fields internationally, to present and discuss new findings and important issues. Moreover, this meeting will provide an outstanding opportunity for more junior scientists and graduate students to present their work in poster format and participate in discussions. Some poster presenters will be selected to give short talks. The accompanying Gordon Research Seminar will provide additional opportunities for students and post-doctoral fellows to network, prepare for the GRC, present their work orally, and gain experience and feedback from their peers.

 描述（由申请人提供）：细胞凋亡是有核细胞生理性死亡的主要机制，并且在后生动物的整个生命周期中持续存在。细胞凋亡的规模（在人类中，每天大约有 1011 个细胞凋亡）需要一个有效的尸体识别和清除系统。事实上，凋亡细胞的快速清除是一个关键的稳态过程，代表生理细胞死亡程序的最后一步。凋亡细胞的清除发生在没有炎症的情况下；事实上，凋亡细胞具有强大的免疫抑制作用。凋亡细胞清除过程的失败与系统性红斑狼疮、类风湿性关节炎和包括动脉粥样硬化在内的其他病理的慢性炎症和自身免疫特征有关。虽然许多分子细节仍有待阐明，但近年来，凋亡细胞识别和清除过程的大致轮廓已成为人们关注的焦点。此外，很明显，这些机制在广泛的不同生理和病理过程中发挥着深远的作用，从塑造神经网络到微生物发病机制。对这些不同环境的检查既扩大了我们对细胞凋亡过程重要性的认识，又提供了独特的见解，可以增强分子特征并促进治疗干预措施的发展。 2015年凋亡细胞识别和清除戈登研究会议将探讨整个进化过程中凋亡细胞识别和清除机制的分子细节，包括凋亡免疫调节。与凋亡细胞清除机制的致病性破坏、神经元发育和肺稳态过程中的凋亡细胞清除、凋亡识别和凝血之间的关系以及这些过程的衰老相关影响有关的问题也将是讨论的主要焦点。这次会议是唯一致力于综合探索这些主题的定期国际会议，将汇集具有不同基础和临床学科专业知识的不同研究人员群体，他们在 这些领域的国际前沿，展示和讨论新发现和重要问题。此外，本次会议将为更多的初级科学家和研究生提供一个以海报形式展示其工作并参与讨论的绝佳机会。一些海报展示者将被选做简短的演讲。随之而来的戈登研究研讨会将为学生和博士后研究员提供额外的机会，让他们建立联系、为 GRC 做准备、口头展示他们的工作，并从同行那里获得经验和反馈。