Exploring the Effects of Strength Training on Depressive Symptoms and Cardiovascular Risk in Black Men

探索力量训练对黑人抑郁症状和心血管风险的影响

• 批准号: 9182593
• 负责人: Andrew M Busch
• 金额: $ 18.86万
• 依托单位: COLUMBIA UNIVERSITY TEACHERS COLLEGE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-26 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9182593
• 关键词: Accounting; Acute; Address; Aerobic; Affect; African American; American Heart Association; Blinded; Blood Pressure; Body Composition; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cessation of life; Clinical; Clinical Trials; Cognitive; Data; Depressed mood; Depressive disorder; Development; Diagnosis; Exercise; Female; Funding; Future; Health; Health behavior; Heart Diseases; Individual; Intervention; Interview; Interviewer; Link; Literature; Masculine; Measures; Mediator of activation protein; Mental Depression; Methods; Minority; Moods; Participant; Patient Self-Report; Pharmaceutical Preparations; Pharmacological Treatment; Physical Exercise; Physiological; Preparation; Procedures; Psychiatric therapeutic procedure; Psychotherapy; Public Health; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Risk Factors; Risk Reduction; Sampling; Self Concept; Severities; Site; Sleep; Smoker; Stroke; Surveys; Techniques; Testing; Training Programs; Waist-Hip Ratio; Weight; Weight Lifting; abstracting; base; blind; blood lipid; burden of illness; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; combat; depressive symptoms; efficacy testing; exercise program; experience; follow-up; health disparity; improved; inflammatory marker; innovation; male health; meetings; men; mortality; preference; primary outcome; programs; prospective; psychologic; secondary outcome; sedentary; self esteem; social; social stigma; strength training

Project Summary/Abstract Depression is severely undertreated in Black men. Significant reasons for this include that traditional psychiatric treatments (i.e., psychotherapy and medication) are less acceptable to Black men, and that Black men report significant stigma regarding seeking these treatments. Depression also has major health consequences, including increased occurrence and worsening of cardiovascular disease (CVD), and even CVD mortality. We propose to address gaps in the literature and advance the field of minority men’s health by conducting the first randomized controlled trial testing the effects of strength training (i.e., weight lifting) on depression and cardiovascular health in a sample of depressed Black men. A total of 50 self-identifying Black men who meet a clinical level of depression will be randomized into a 12-week strength training (ST) program or a 12-week contact control. Both groups will meet on-site twice per week during the 12-week program, and follow-up assessments will occur at the end of the 12-weeks and at a 3-month follow-up. Blind to condition research staff will conduct assessments at baseline, end-of-treatment, and 3-month follow-up. Qualitative interviews will be conducted immediately after the 3-month follow-up to gather input on participants’ experiences and preferences. The primary outcome will be depression severity (measured by interview). Secondary outcomes will be inflammatory markers and CVD indicators (e.g., blood lipids, blood pressure, waist-to-hip ratio, body composition). The overall aim of this exploratory (R21) study is to establish the feasibility, acceptability, and initial efficacy of strength training as an intervention for depression in Black men. Specific aims are (1) To assess the feasibility and acceptability of recruitment, retention, assessment, and intervention procedures among depressed Black men, (2) To obtain preliminary evidence of efficacy in preparation for a future R01-supported randomized clinical trial, and (3) To explore potential mediators of the effect of ST on depression, including physiological (i.e., sleep quality) and psychological (i.e., self-esteem, acute changes in affect, enjoyment of exercise, physical self-concept) variables. The proposed research will lay the groundwork for a larger efficacy study of ST for Black men that will be fully powered to detect changes in both depression and CVD risk over long-term follow-up. Such a trial would be an initial step to combating major health disparities regarding CVD and treatment for depression among Black men.

项目总结/摘要 抑郁症在黑人中严重不足。这其中的重要原因包括， 精神病治疗（即，心理治疗和药物治疗）是黑人男性较难接受的，黑人 男子报告说，在寻求这些治疗方面存在严重的耻辱感。抑郁症也有重大健康 后果，包括心血管疾病（CVD）的发生率增加和恶化，甚至 CVD死亡率。我们建议解决文献中的空白，并通过以下方式推进少数群体男性健康领域的工作： 进行测试力量训练效果的第一个随机对照试验（即，举重） 抑郁症和心血管健康在一个样本的抑郁症黑人男子。总共有50个自称是黑人的人 符合临床抑郁水平的男性将被随机分配到一个为期12周的力量训练（ST）项目中 或者12周的接触控制在为期12周的项目中，两个小组每周将在现场会面两次， 将在12周结束时和3个月随访时进行随访评估。无视条件 研究人员将在基线、治疗结束和3个月随访时进行评估。定性 在3个月的随访后，将立即进行访谈，以收集参与者对 经验和偏好。主要结果将是抑郁严重程度（通过访谈测量）。 次要结局将是炎症标志物和CVD指标（例如，血脂，血压， 腰臀比、身体成分）。本探索性（R21）研究的总体目的是确定 力量训练作为黑人男性抑郁症干预措施的可行性、可接受性和初步疗效。 具体目标是：（1）评估招聘、保留、评估和 抑郁症黑人男性的干预程序，（2）获得有效的初步证据， 为将来R 01支持的随机临床试验做准备，以及（3）探索潜在的介质， ST对抑郁症的影响，包括生理上的（即，睡眠质量）和心理（即，自尊 情感、运动乐趣、身体自我概念的剧烈变化）变量。拟议的研究将 为更大规模的黑人男性ST疗效研究奠定基础，该研究将完全有能力检测变化 抑郁症和心血管疾病的风险。这样的审判将是打击恐怖主义的第一步。 黑人男性在心血管疾病和抑郁症治疗方面存在重大健康差异。