Exploring the Effects of Strength Training on Depressive Symptoms and Cardiovascular Risk in Black Men

探索力量训练对黑人抑郁症状和心血管风险的影响

• 批准号: 9357672
• 负责人: Andrew M Busch
• 金额: $ 21.27万
• 依托单位: COLUMBIA UNIVERSITY TEACHERS COLLEGE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-26 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9357672
• 关键词: Acute; Address; Aerobic; Affect; African American; American Heart Association; Blinded; Blood Pressure; Body Composition; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cessation of life; Clinical; Clinical Trials; Cognitive; Data; Depressed mood; Depressive disorder; Development; Diagnosis; Exercise; Female; Funding; Future; Health; Health behavior; Heart Diseases; Individual; Intervention; Interview; Interviewer; Link; Literature; Masculine; Measures; Mediator of activation protein; Mental Depression; Methods; Minority; Moods; Motivation; Participant; Patient Self-Report; Pharmaceutical Preparations; Pharmacological Treatment; Physiological; Preparation; Procedures; Psychiatric therapeutic procedure; Psychotherapy; Public Health; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Recruitment Activity; Reporting; Research; Risk Factors; Risk Reduction; Sampling; Self Concept; Severities; Site; Sleep; Smoker; Stroke; Surveys; Techniques; Testing; Training Programs; Waist-Hip Ratio; Weight; Weight Lifting; base; blind; blood lipid; burden of illness; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; combat; depressive symptoms; efficacy study; efficacy testing; exercise program; experience; follow up assessment; follow-up; health disparity; improved; inflammatory marker; innovation; male health; men; mortality; preference; primary outcome; programs; prospective; psychologic; secondary outcome; sedentary; self esteem; social; social stigma; strength training

Project Summary/Abstract Depression is severely undertreated in Black men. Significant reasons for this include that traditional psychiatric treatments (i.e., psychotherapy and medication) are less acceptable to Black men, and that Black men report significant stigma regarding seeking these treatments. Depression also has major health consequences, including increased occurrence and worsening of cardiovascular disease (CVD), and even CVD mortality. We propose to address gaps in the literature and advance the field of minority men’s health by conducting the first randomized controlled trial testing the effects of strength training (i.e., weight lifting) on depression and cardiovascular health in a sample of depressed Black men. A total of 50 self-identifying Black men who meet a clinical level of depression will be randomized into a 12-week strength training (ST) program or a 12-week contact control. Both groups will meet on-site twice per week during the 12-week program, and follow-up assessments will occur at the end of the 12-weeks and at a 3-month follow-up. Blind to condition research staff will conduct assessments at baseline, end-of-treatment, and 3-month follow-up. Qualitative interviews will be conducted immediately after the 3-month follow-up to gather input on participants’ experiences and preferences. The primary outcome will be depression severity (measured by interview). Secondary outcomes will be inflammatory markers and CVD indicators (e.g., blood lipids, blood pressure, waist-to-hip ratio, body composition). The overall aim of this exploratory (R21) study is to establish the feasibility, acceptability, and initial efficacy of strength training as an intervention for depression in Black men. Specific aims are (1) To assess the feasibility and acceptability of recruitment, retention, assessment, and intervention procedures among depressed Black men, (2) To obtain preliminary evidence of efficacy in preparation for a future R01-supported randomized clinical trial, and (3) To explore potential mediators of the effect of ST on depression, including physiological (i.e., sleep quality) and psychological (i.e., self-esteem, acute changes in affect, enjoyment of exercise, physical self-concept) variables. The proposed research will lay the groundwork for a larger efficacy study of ST for Black men that will be fully powered to detect changes in both depression and CVD risk over long-term follow-up. Such a trial would be an initial step to combating major health disparities regarding CVD and treatment for depression among Black men.

项目摘要/摘要 黑人对抑郁症的不足。这样做的重要原因包括传统 精神疗法（即心理治疗和药物）对黑人不太接受，黑人 男性报告了寻求这些治疗的重要污名。抑郁症也有重大健康 后果，包括增加的发生和心血管疾病（CVD），甚至 CVD死亡率。我们建议解决文献中的差距，并通过 进行第一个随机对照试验，以测试力量训练（即举重）对 抑郁症的黑人样本中的抑郁症和心血管健康。共有50个自我识别的黑色 遇到临床抑郁水平的男性将被随机分为12周的力量训练（ST）计划 或12周的接触控制。这两个小组将在12周的计划中每周两次见面， 随访评估将在12周结束时进行，并进行3个月的随访。盲目的状况 研究人员将在基线，治疗结束和3个月的随访中进行评估。定性 访谈将在为期3个月后立即进行，以收集参与者的意见 经验和偏好。主要结果将是抑郁症的严重程度（通过访谈衡量）。 次要结果将是炎症标记和CVD指标（例如，血脂，血压， 腰围比，身体成分）。这项探索性研究（R21）的总体目的是建立 力量训练的可行性，可接受性和初始效率作为黑人抑郁症的干预。 具体目的是（1）评估招聘，保留，评估和 沮丧的黑人中的干预程序，（2）获得效率的初步证据 准备未来的R01支持的随机临床试验，（3）探索潜在的介体 ST对抑郁症的影响，包括身体（即睡眠质量）和心理学（即自尊心， 情感急性变化，运动享受，身体自我概念）变量。拟议的研究将 为黑人的ST进行更大的效率研究奠定基础，这些研究将完全动力检测变化 在抑郁症和CVD中，长期随访的风险。这样的审判将是打击的第一步 黑人男性的CVD和抑郁症治疗的重大健康差异。