COllaborative Care to Preserve PErformance in Cancer (COPE) Trial

保持癌症表现的协作护理 (COPE) 试验

基本信息

  • 批准号:
    8816053
  • 负责人:
  • 金额:
    $ 60.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-03-01 至 2016-02-29
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Disablement affects about 40% of patients in the late stages of cancer, devastates their quality of life (QoL), and radically increases healthcare costs. Data strongly suggest that proactively treating the causes of cancer- related disablement; physical impairments, pain, and related immobility, can significantly prolong patients' functional independence, improve their QoL and avoid unneeded expensive and extended hospitalizations. Current rehabilitation service delivery models are reactive in nature and tend to focus on catastrophic disability, characteristics that render them ill suited to detect or address early disablement in cancer or any vulnerable patient group. An empirically validated collaborative approach to pain care, the three component model (TCM), optimizes important clinical outcomes and may provide an ideal framework to overcome barriers to the timely integration of rehabilitation services into cancer care. However, the TCM, given its pharmacotherapeutic focus cannot be directly applied to rehabilitation and its need for in-person interaction. We have, therefore, developed a novel extension of the TCM that targets disablement by engaging local physical therapists to address patients' physical impairments and related immobility. Preliminary work shows that this extension (TCM-Rehabilitation Services (TCM-RS)) is highly effective and well received by patients and local therapists. We propose to rigorously examine its effectiveness and costs among 495 patients with late stage cancer in the COllaborative Care to Preserve PErformance in Cancer (COPE) Trial. Since pain is strongly implicated in cancer-related disablement, optimized pain control may maximize the TCM-RS' benefit. COPE will therefore include, in addition to the two arms of; 1) enhanced usual care, and 2) rehabilitation services targeting physical impairments and immobility via the TCM-RS, a third arm; 3) TCM-RS plus conventional TCM pain management TCM-RS+Pain. Participants will undergo an initial 4-week intervention period and then be followed for a total of 6 months with the trial's primary outcome, functional status, and two secondary outcomes, pain and health utilities, being assessed monthly via an automated, telephonic monitoring system. Additional outcomes; QoL, physical activity, and caregiver burden, will be assessed at baseline, 3, and 6 months. Costs will be abstracted from clinical records and administrative databases. Our objective is to estimate the effectiveness, as well as the cost-benefit and -utility implications of the TCM-RS and TCM- RS+Pain in order to inform future research and policy in the means to minimize functional loss in chronically diseased populations.
描述(由申请人提供):残疾影响了大约40%的晚期癌症患者,破坏了他们的生活质量(QoL),并从根本上增加了医疗费用。数据强烈表明,积极治疗癌症相关致残的原因;身体损伤、疼痛和相关的行动不便,可以显著延长患者的功能独立性,改善他们的生活质量,避免不必要的昂贵和延长的住院治疗。目前的康复服务提供模式本质上是反应性的,往往侧重于灾难性残疾,这使得它们不适合发现或解决癌症或任何弱势患者群体的早期残疾。一种经过实证验证的疼痛护理合作方法,三成分模型(TCM),优化了重要的临床结果,并可能提供一个理想的框架,以克服及时将康复服务整合到癌症护理中的障碍。然而,中医以药物治疗为主,不能直接应用于康复治疗,需要面对面的互动。因此,我们开发了一种新的中医药延伸,通过与当地物理治疗师合作,解决患者的身体损伤和相关的行动不便,以残疾为目标。初步工作表明,这一扩展(中医康复服务(TCM-RS))非常有效,受到患者和当地治疗师的欢迎。我们建议在495名晚期癌症患者的协同护理中严格检查其有效性和成本,以保持癌症的表现(COPE)试验。由于疼痛与癌症相关的残疾密切相关,优化的疼痛控制可以最大限度地提高中医- rs的效益。因此,COPE除了包括以下两个部门外,还将包括;1)加强常规护理,2)通过中医- rs(第三个分支)提供针对身体损伤和行动不便的康复服务;3)中医- rs +传统中医疼痛管理。参与者将经历最初的4周干预期,然后总共随访6个月,试验的主要结果,功能状态,以及两个次要结果,疼痛和健康效用,每月通过自动电话监测系统进行评估。额外的结果;将在基线、3个月和6个月时评估生活质量、身体活动和照顾者负担。费用将从临床记录和行政数据库中提取。我们的目标是评估中医-RS和中医-RS +疼痛的有效性,以及成本效益和效用影响,以便为未来的研究和政策提供信息,以最大限度地减少慢性疾病人群的功能丧失。

项目成果

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Andrea Lynne Cheville其他文献

Andrea Lynne Cheville的其他文献

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{{ truncateString('Andrea Lynne Cheville', 18)}}的其他基金

Achieving Equity through SocioCulturally-informed, Digitally-Enabled Cancer Pain managemeNT” (ASCENT) Clinical Trial
通过社会文化知情、数字化的癌症疼痛管理 NT™ (ASCENT) 临床试验实现公平
  • 批准号:
    10539159
  • 财政年份:
    2022
  • 资助金额:
    $ 60.05万
  • 项目类别:
Project HoPe: Achieving Home Discharge for institutionally-bound Patients with PROMs, AI, and the EHR
HoPe 项目:利用 PROM、AI 和 EHR 使住院患者出院回家
  • 批准号:
    10675460
  • 财政年份:
    2022
  • 资助金额:
    $ 60.05万
  • 项目类别:
Project HoPe: Achieving Home Discharge for institutionally-bound Patients with PROMs, AI, and the EHR
HoPe 项目:利用 PROM、AI 和 EHR 使住院患者出院回家
  • 批准号:
    10456362
  • 财政年份:
    2022
  • 资助金额:
    $ 60.05万
  • 项目类别:
Non-pharmacological Options in postoperative Hospital-based And Rehabilitation pain Management (NOHARM) pragmatic clinical trial
术后医院康复疼痛管理 (NOHARM) 实用临床试验中的非药物选择
  • 批准号:
    10210513
  • 财政年份:
    2019
  • 资助金额:
    $ 60.05万
  • 项目类别:
Non-pharmacological Options in postoperative Hospital-based And Rehabilitation pain Management (NOHARM) pragmatic clinical trial
术后医院康复疼痛管理 (NOHARM) 实用临床试验中的非药物选择
  • 批准号:
    10468778
  • 财政年份:
    2019
  • 资助金额:
    $ 60.05万
  • 项目类别:
Non-pharmacological Options in postoperative Hospital-based And Rehabilitation pain Management (NOHARM) pragmatic clinical trial
术后医院康复疼痛管理 (NOHARM) 实用临床试验中的非药物选择
  • 批准号:
    10263299
  • 财政年份:
    2019
  • 资助金额:
    $ 60.05万
  • 项目类别:
Computerized Adaptive Testing to Direct Delivery of Hospital-Based Rehabilitation
计算机化自适应测试直接提供医院康复服务
  • 批准号:
    9229048
  • 财政年份:
    2015
  • 资助金额:
    $ 60.05万
  • 项目类别:
Computerized Adaptive Testing to Direct Delivery of Hospital-Based Rehabilitation
计算机化自适应测试直接提供医院康复服务
  • 批准号:
    9045667
  • 财政年份:
    2015
  • 资助金额:
    $ 60.05万
  • 项目类别:
COllaborative Care to Preserve PErformance in Cancer (COPE) Trial
保持癌症表现的协作护理 (COPE) 试验
  • 批准号:
    8434848
  • 财政年份:
    2012
  • 资助金额:
    $ 60.05万
  • 项目类别:
COllaborative Care to Preserve PErformance in Cancer (COPE) Trial
保持癌症表现的协作护理 (COPE) 试验
  • 批准号:
    8625279
  • 财政年份:
    2012
  • 资助金额:
    $ 60.05万
  • 项目类别:

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