Catalytic Methods for Stereoselective 1,2-Cis Glycosylation

立体选择性 1,2-顺式糖基化的催化方法

基本信息

  • 批准号:
    9163857
  • 负责人:
  • 金额:
    $ 63.27万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-01 至 2020-05-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY The field of glycoscience has burgeoned in the last several decades, leading to the identification of many oligosaccharides and glycoconjugates which could serve critical roles in a wide range of biological processes. This rapid growth of knowledge about the function of carbohydrates has attracted increasing attention from biological, pharmacological, and medicinal researchers. Meeting their research demands require access to significant quantities of well- defined bioactive carbohydrates. This has prompted resurgence in synthetic interest, with a particular focus on new approaches to the glycosidic bond. Even with the abundance of elegant reports for stereoselective construction glycosidic linkages, catalytic stereoselective synthesis of α- and β-oligosaccharides and glycoconjugates remains challenging and can only be achieved in the context of a limited set of conditions. One of glycosidic bonds that has historically proven challenging is β-mannosidic bond. This proposal seeks to address this unmet need through the development of a series of predictable and stereoselective α- and β-1,2-cis glycosylation reactions via the merger of photoredox catalysis with nickel catalysis. In each Specific Aim, a different type of directing groups and ligands attached to nickel catalyst will be employed, and a fundamentally different strategy will be investigated to control anomeric selectivity. As such, the proposed methods will provide a variety of new strategies for the construction of challenging α- and β-1,2-cis glycosidic bonds. The proposed stereoselective glycosylation reactions via dual catalysis are significant because these type of glycosidic bonds are widely prevalent in bioactive oligosaccharides and glycoconjugates. The proposed reactions are predictable and stereoselective and conducted under mild and operationally simple conditions without requiring advanced training. Importantly, the new methods have the potential for transforming into automated synthesis.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Hien M Nguyen其他文献

Hien M Nguyen的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Hien M Nguyen', 18)}}的其他基金

Development of Catalytic Glycosylations and Biologically Important Glycosaminoglycans
催化糖基化和具有生物学重要性的糖胺聚糖的发展
  • 批准号:
    10622180
  • 财政年份:
    2023
  • 资助金额:
    $ 63.27万
  • 项目类别:
Synthesis and Evaluation of Carbohydrate Vaccine Adjuvants
碳水化合物疫苗佐剂的合成与评价
  • 批准号:
    10538831
  • 财政年份:
    2022
  • 资助金额:
    $ 63.27万
  • 项目类别:
Synthesis and Evaluation of Carbohydrate Vaccine Adjuvants
碳水化合物疫苗佐剂的合成与评价
  • 批准号:
    10642889
  • 财政年份:
    2022
  • 资助金额:
    $ 63.27万
  • 项目类别:
Strategies for Expedited Synthesis of Sulfated Aminoglycans
硫酸化氨基聚糖的快速合成策略
  • 批准号:
    10371884
  • 财政年份:
    2020
  • 资助金额:
    $ 63.27万
  • 项目类别:
Strategies for Expedited Synthesis of Sulfated Aminoglycans
硫酸化氨基聚糖的快速合成策略
  • 批准号:
    10594458
  • 财政年份:
    2020
  • 资助金额:
    $ 63.27万
  • 项目类别:
Synthesis and Evaluation of Zwitterionic Carbohydrate Immunostimulants
两性离子碳水化合物免疫增强剂的合成与评价
  • 批准号:
    9109179
  • 财政年份:
    2016
  • 资助金额:
    $ 63.27万
  • 项目类别:
Synthesis of Complex Carbohydrates.
复杂碳水化合物的合成。
  • 批准号:
    8640956
  • 财政年份:
    2012
  • 资助金额:
    $ 63.27万
  • 项目类别:
Synthesis of Complex Carbohydrates.
复杂碳水化合物的合成。
  • 批准号:
    8826141
  • 财政年份:
    2012
  • 资助金额:
    $ 63.27万
  • 项目类别:
Tailoring Structures of Sulfated Oligosaccharides for Modulating Heparanase Activity
用于调节乙酰肝素酶活性的硫酸低聚糖的剪裁结构
  • 批准号:
    10164799
  • 财政年份:
    2012
  • 资助金额:
    $ 63.27万
  • 项目类别:
Tailoring Structures of Sulfated Oligosaccharides for Modulating Heparanase Activity
用于调节乙酰肝素酶活性的硫酸低聚糖的剪裁结构
  • 批准号:
    9816301
  • 财政年份:
    2012
  • 资助金额:
    $ 63.27万
  • 项目类别:

相似国自然基金

湍流和化学交互作用对H2-Air-H2O微混燃烧中NO生成的影响研究
  • 批准号:
    51976048
  • 批准年份:
    2019
  • 资助金额:
    61.0 万元
  • 项目类别:
    面上项目

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 63.27万
  • 项目类别:
    Standard Grant
SBIR Phase I: High-Efficiency Liquid Desiccant Regenerator for Desiccant Enhanced Evaporative Air Conditioning
SBIR 第一阶段:用于干燥剂增强蒸发空调的高效液体干燥剂再生器
  • 批准号:
    2335500
  • 财政年份:
    2024
  • 资助金额:
    $ 63.27万
  • 项目类别:
    Standard Grant
Catalyzing Sustainable Air Travel: Unveiling Consumer Willingness to Pay for Sustainable Aviation Fuel through Information Treatment in Choice Experiment and Cross-Country Analysis
促进可持续航空旅行:通过选择实验和跨国分析中的信息处理揭示消费者支付可持续航空燃油的意愿
  • 批准号:
    24K16365
  • 财政年份:
    2024
  • 资助金额:
    $ 63.27万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
COMPAS: co integration of microelectronics and photonics for air and water sensors
COMPAS:微电子学和光子学的共同集成,用于空气和水传感器
  • 批准号:
    10108154
  • 财政年份:
    2024
  • 资助金额:
    $ 63.27万
  • 项目类别:
    EU-Funded
Simulating Urban Air Pollution In The Lab
在实验室模拟城市空气污染
  • 批准号:
    MR/Y020014/1
  • 财政年份:
    2024
  • 资助金额:
    $ 63.27万
  • 项目类别:
    Fellowship
Collaborative Research: Phenotypic and lineage diversification after key innovation(s): multiple evolutionary pathways to air-breathing in labyrinth fishes and their allies
合作研究:关键创新后的表型和谱系多样化:迷宫鱼及其盟友呼吸空气的多种进化途径
  • 批准号:
    2333683
  • 财政年份:
    2024
  • 资助金额:
    $ 63.27万
  • 项目类别:
    Continuing Grant
Collaborative Research: Phenotypic and lineage diversification after key innovation(s): multiple evolutionary pathways to air-breathing in labyrinth fishes and their allies
合作研究:关键创新后的表型和谱系多样化:迷宫鱼及其盟友呼吸空气的多种进化途径
  • 批准号:
    2333684
  • 财政年份:
    2024
  • 资助金额:
    $ 63.27万
  • 项目类别:
    Continuing Grant
CRII: CSR: Towards an Edge-enabled Software-Defined Vehicle Framework for Dynamic Over-the-Air Updates
CRII:CSR:迈向支持边缘的软件定义车辆框架,用于动态无线更新
  • 批准号:
    2348151
  • 财政年份:
    2024
  • 资助金额:
    $ 63.27万
  • 项目类别:
    Standard Grant
Development of a low-pressure loss air purification device using rotating porous media and a proposal for its use in ventilation systems
使用旋转多孔介质的低压损失空气净化装置的开发及其在通风系统中的使用建议
  • 批准号:
    24K17404
  • 财政年份:
    2024
  • 资助金额:
    $ 63.27万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
AIR QUALITY AND HEALTH IMPACT OF PRIMARY SEMI-VOLATILE AND SECONDARY PARTICLES AND THEIR ABATEMENT
一次半挥发性颗粒和二次颗粒对空气质量和健康的影响及其消除
  • 批准号:
    10100997
  • 财政年份:
    2024
  • 资助金额:
    $ 63.27万
  • 项目类别:
    EU-Funded
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了