Handheld Portable Adaptive Optics Scanning Laser Ophthalmoscope for Imaging Young Children

用于幼儿成像的手持式便携式自适应光学扫描激光检眼镜

• 批准号: 9167486
• 负责人: Sina Farsiu
• 金额: $ 19.27万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9167486
• 关键词: Adult; Animal Model; Biological Markers; Blindness; Canis familiaris; Characteristics; Child; Child Care; Childhood; Clinical; Clinical Research; Color; Computer software; Development; Diagnostic; Diagnostic Procedure; Disease; Disease Progression; Etiology; Eye diseases; Feedback; Funding; Goals; Hand; Image; Imaging Device; Imaging technology; Individual; Infant; Inherited; Injury; Lasers; Lead; Macular degeneration; Measurement; Methodology; Monitor; Motion; Neonatal; Ophthalmologist; Ophthalmoscopes; Ophthalmoscopy; Optical Coherence Tomography; Optics; Outcome; Pathology; Patients; Peer Review; Performance; Pharmacotherapy; Photoreceptors; Pilot Projects; Population; Positioning Attribute; Premature Infant; Research; Research Personnel; Resolution; Retina; Retinal; Retinal Diseases; Retinal Dystrophy; Retinopathy of Prematurity; Risk; Scanning; Scientist; Severities; Staging; Structure; System; Systems Development; Technology; Testing; Three-Dimensional Image; Vision; Work; abstracting; adaptive optics; base; clinical care; cost efficient; design; image processing; imaging biomarker; imaging software; imaging system; improved; in vivo; innovation; macula; multidisciplinary; neonate; novel; novel therapeutics; screening; software development; tool; young adult

Abstract Eye diseases of young children, if not detected and treated early, can lead to serious vision loss and even blindness. As an alternative to the classic 2-D color photographs, we have pioneered utilization of handheld spectral domain optical coherence tomography (HH-SDOCT) imaging systems to provide 3-D images of intra- retinal structures. Our previous studies based on HH-SDOCT of neonatal retina have already provided unique and previously unseen information about disease progression in young children. However, due to the limited resolution of conventional OCT, HH-SDOCT does not visualize individual photoreceptors. In vivo photoreceptor imaging, achieved by adaptive optics scanning laser ophthalmoscopy (AOSLO), has enhanced the way vision scientists and ophthalmologists understand retinal structure, function, and the etiology of numerous retinal pathologies in adults. Unfortunately, the complexity and large footprint of current AOSLO systems limits imaging to cooperative adults, excluding an important fraction of patients: small children, infants, and the bedridden. Our long-term goal is to improve the vision outcomes of at-risk young children with retinal diseases through earlier and better directed therapy. To achieve this goal, the overall objective of this proposal is to develop accurate yet portable and non-invasive diagnostic tools customized for young children care. In this need-driven proposal, we hypothesize that by taking advantage of recent advances in image processing and optics as an integrated technology, a small form-factor, portable hand-held (HH) AOSLO system capable of capturing retinal images with high resolution and motion stability can be obtained, which will visualize individual foveal photoreceptors and ultimately provide quantitative measurements of novel imaging biomarkers of the onset and progression of retinal diseases in young children. We will achieve our objectives by pursuit of the following specific aims: #1: Develop hardware to build the first HH-AOSLO system optimized for retinal imaging of young children. #2: Develop software to control the hardware in Aim 1 and to automatically quantify potential imaging biomarkers of the onset and progression of retinal diseases in young children. #3: Perform a pilot study in adults and young children. Evaluate, provide feedback, and improve the performance of methodologies in Aims 1&2, and then test the utility and validity of images and measurements compared to conventional diagnostic methods. The results of this study have the potential to provide practical diagnostic tools that will revolutionize the management of retinal diseases during the period of retinal development and maturation. This contribution would be significant as the first step in a continuum of research leading to better-directed therapy of ocular diseases in young children based on accurate quantitative measurement of disease imaging biomarkers and accurate staging of foveal development.

摘要 幼儿的眼疾，如果不及早发现和治疗，可能会导致严重的视力丧失，甚至 失明。作为经典的2-D彩色照片的替代方案，我们率先使用了手持设备 光谱域光学相干层析成像(HH-SDOCT)成像系统，用于提供内部的三维图像 视网膜结构。我们之前基于HH-SDOCT的新生儿视网膜研究已经提供了独特的 以及以前未见过的有关幼儿疾病进展的信息。然而，由于有限的 与传统的OCT相比，HH-SDOCT不能显示单个感光器。活体光感受器 通过自适应光学扫描激光眼底镜(AOSLO)实现的成像增强了视力的方式 科学家和眼科医生了解视网膜的结构、功能和许多视网膜的病因。 成人的病理学。不幸的是，当前AOSLO系统的复杂性和大占地面积限制了成像 对于合作的成年人，不包括重要的一部分患者：儿童、婴儿和卧床不起的人。 我们的长期目标是改善患有视网膜疾病的高危儿童的视力结果 更早更好地指导治疗。为了实现这一目标，这项建议的总体目标是发展 为幼儿护理量身定做的准确但便携的非侵入性诊断工具。在这种需求驱动的情况下 提案中，我们假设通过利用图像处理和光学的最新进展作为一种 集成技术，能够捕获视网膜的小型便携式手持(HH)AOSLO系统 可以获得高分辨率和运动稳定性的图像，这将使单个中心凹可视化 并最终提供新的影像生物标记物的定量测量的起始和 儿童视网膜疾病的进展。我们将通过以下几个方面实现目标 具体目标：#1：开发硬件，建立第一个针对青少年视网膜成像进行优化的HH-AOSLO系统 孩子们。#2：开发软件来控制目标1中的硬件并自动量化潜在成像 幼儿视网膜疾病发生和发展的生物标志物。#3：对成年人进行一项先导性研究 和年幼的孩子。评估、提供反馈并改进目标1和2中的方法的性能； 然后与常规诊断方法进行比较，检验图像和测量方法的实用性和有效性。 这项研究的结果有可能提供实用的诊断工具，将彻底改变 视网膜发育和成熟期视网膜疾病的处理。这一贡献将 作为导致更好地指导眼病治疗的连续研究的第一步，具有重要意义 基于婴幼儿疾病影像生物标志物的准确定量测量 中央凹发育的阶段。