Handheld Portable Adaptive Optics Scanning Laser Ophthalmoscope for Imaging Young Children

用于幼儿成像的手持式便携式自适应光学扫描激光检眼镜

• 批准号: 9167486
• 负责人: Sina Farsiu
• 金额: $ 19.27万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9167486
• 关键词: Adult; Animal Model; Biological Markers; Blindness; Canis familiaris; Characteristics; Child; Child Care; Childhood; Clinical; Clinical Research; Color; Computer software; Development; Diagnostic; Diagnostic Procedure; Disease; Disease Progression; Etiology; Eye diseases; Feedback; Funding; Goals; Hand; Image; Imaging Device; Imaging technology; Individual; Infant; Inherited; Injury; Lasers; Lead; Macular degeneration; Measurement; Methodology; Monitor; Motion; Neonatal; Ophthalmologist; Ophthalmoscopes; Ophthalmoscopy; Optical Coherence Tomography; Optics; Outcome; Pathology; Patients; Peer Review; Performance; Pharmacotherapy; Photoreceptors; Pilot Projects; Population; Positioning Attribute; Premature Infant; Research; Research Personnel; Resolution; Retina; Retinal; Retinal Diseases; Retinal Dystrophy; Retinopathy of Prematurity; Risk; Scanning; Scientist; Severities; Staging; Structure; System; Systems Development; Technology; Testing; Three-Dimensional Image; Vision; Work; abstracting; adaptive optics; base; clinical care; cost efficient; design; image processing; imaging biomarker; imaging software; imaging system; improved; in vivo; innovation; macula; multidisciplinary; neonate; novel; novel therapeutics; screening; software development; tool; young adult

Abstract Eye diseases of young children, if not detected and treated early, can lead to serious vision loss and even blindness. As an alternative to the classic 2-D color photographs, we have pioneered utilization of handheld spectral domain optical coherence tomography (HH-SDOCT) imaging systems to provide 3-D images of intra- retinal structures. Our previous studies based on HH-SDOCT of neonatal retina have already provided unique and previously unseen information about disease progression in young children. However, due to the limited resolution of conventional OCT, HH-SDOCT does not visualize individual photoreceptors. In vivo photoreceptor imaging, achieved by adaptive optics scanning laser ophthalmoscopy (AOSLO), has enhanced the way vision scientists and ophthalmologists understand retinal structure, function, and the etiology of numerous retinal pathologies in adults. Unfortunately, the complexity and large footprint of current AOSLO systems limits imaging to cooperative adults, excluding an important fraction of patients: small children, infants, and the bedridden. Our long-term goal is to improve the vision outcomes of at-risk young children with retinal diseases through earlier and better directed therapy. To achieve this goal, the overall objective of this proposal is to develop accurate yet portable and non-invasive diagnostic tools customized for young children care. In this need-driven proposal, we hypothesize that by taking advantage of recent advances in image processing and optics as an integrated technology, a small form-factor, portable hand-held (HH) AOSLO system capable of capturing retinal images with high resolution and motion stability can be obtained, which will visualize individual foveal photoreceptors and ultimately provide quantitative measurements of novel imaging biomarkers of the onset and progression of retinal diseases in young children. We will achieve our objectives by pursuit of the following specific aims: #1: Develop hardware to build the first HH-AOSLO system optimized for retinal imaging of young children. #2: Develop software to control the hardware in Aim 1 and to automatically quantify potential imaging biomarkers of the onset and progression of retinal diseases in young children. #3: Perform a pilot study in adults and young children. Evaluate, provide feedback, and improve the performance of methodologies in Aims 1&2, and then test the utility and validity of images and measurements compared to conventional diagnostic methods. The results of this study have the potential to provide practical diagnostic tools that will revolutionize the management of retinal diseases during the period of retinal development and maturation. This contribution would be significant as the first step in a continuum of research leading to better-directed therapy of ocular diseases in young children based on accurate quantitative measurement of disease imaging biomarkers and accurate staging of foveal development.

抽象的 幼儿的眼部疾病，如果未发现和早期治疗，可能会导致严重的视力丧失，甚至可能导致 失明。作为经典二维彩色照片的替代方案，我们有掌握的率利用 光谱域光学相干断层扫描（HH-SDOCT）成像系统可提供3-D图像 视网膜结构。我们以前基于新生儿视网膜HH-SDOCT的研究已经提供了独特的研究 以及以前关于幼儿疾病进展的看不见的信息。但是，由于有限 常规OCT的分辨率HH-SDOCT不会可视化单个感光体。体内光感受器 通过自适应光学扫描激光眼镜检查（AOSLO）实现的成像，增强了视觉的方式 科学家和眼科医生了解许多视网膜的视网膜结构，功能和病因 成人的病理。不幸的是，当前AOSLO系统的复杂性和较大的占地面积限制了成像 对于合作成年人，不包括重要的患者：小儿童，婴儿和卧床不起。 我们的长期目标是通过视网膜疾病的高风险幼儿通过 较早，更好地定向治疗。为了实现这一目标，该提议的总体目标是发展 为幼儿护理而定制的准确但便携式和非侵入性诊断工具。在这种需求驱动的情况下 提案，我们假设，通过利用图像处理和光学的最新进展作为一种 集成技术，一种小型，便携式手持（HH）AOSLO系统，能够捕获视网膜 可以获得高分辨率和运动稳定性的图像，这将可视化单个foveal 感光体并最终提供了对发作和发作的新成像生物标志物的定量测量 幼儿视网膜疾病的进展。我们将通过追求以下内容来实现我们的目标 具体目的：＃1：开发硬件以构建用于年轻视网膜成像的第一个HH-Aoslo系统 孩子们。 ＃2：开发软件以控制AIM 1中的硬件并自动量化潜在的成像 年幼儿童视网膜疾病发作和进展的生物标志物。 ＃3：对成人进行试点研究 和年幼的孩子。评估，提供反馈并提高目标1和2中方法的性能， 然后与常规诊断方法相比，测试图像和测量的效用和有效性。 这项研究的结果有可能提供实用的诊断工具，以彻底改变 在视网膜发育和成熟期间，视网膜疾病的管理。这个贡献会 作为连续研究的第一步，要对眼部疾病进行更好指导的治疗的第一步。 基于对疾病成像生物标志物的准确定量测量和准确的幼儿 中央凹开发的分期。