Portable Motion Compensated SDOCT System for Imaging Young Children

摘要 幼儿的眼疾，如果不及早发现和治疗，可能会导致严重的视力丧失和 甚至是失明。目前，青少年儿童的视网膜疾病主要是通过颜色来记录和监控 照片，尽管它们提供的关于眼科疾病过程和 机械装置。作为经典二维彩色照片的替代，新的谱域光学相干性 断层扫描(SDOCT)成像系统可以提供视网膜内结构的3D图像。在成人中，桌面 SDOCT提供了更多有用的诊断信息，现在是诊断和 视网膜疾病的管理。基于手持SDOCT(HH-SDOCT)快照的初步研究 已经提供了一些关于疾病的独特的和以前看不到的信息 幼儿的进展性。然而，由于婴儿的头部/眼睛运动，要想 有效地为幼年清醒儿童的黄斑进行完整的3-D断层成像，并且准确 测量和量化疾病生物标记物。 我们的长期目标是改善患有眼病的高危儿童的视力结果。 通过更早和更好的指导治疗。为了实现这一目标，我们将利用最近在以下方面的进展 图像处理和光学作为一种综合技术来获取更高分辨率的3D视网膜图像 与任何以前的成像技术相比，运动稳定性更好，这最终将提供 新的影像生物标记物的定量测量在幼儿疾病发生和发展中的应用 眼科疾病。我们将通过追求以下三个具体目标实现我们的目标：目标1： 开发硬件定制手持SDOCT和多普勒SDOCT系统，用于非视网膜成像 给幼儿服用镇静剂。目标2：开发软件来控制目标1中的硬件并自动 分析捕获的图像以检测视网膜疾病的发生和发展的成像生物标志物 在年幼的儿童中。目标3：在成人和幼儿中进行先导性研究。评估、提供反馈和 改进AIMS 1和AIMS 2中的方法性能，然后测试图像和 测量结果与传统诊断方法进行了比较。 这项研究的结果有可能提供实用的诊断工具和方法， 将彻底改变儿科眼科疾病的管理。这一贡献将是重大的，因为 一系列研究的第一步，旨在更好地指导幼儿眼科疾病的治疗 基于疾病影像生物标志物的准确定量测量和中心凹的准确分期 发展。

Abstract Eye diseases of young children, if not detected and treated early, can lead to serious vision loss and even blindness. Currently, retinal diseases in young children are mainly recorded and monitored by color photographs, even though they provide limited information about ophthalmic disease processes and mechanisms. As an alternative to the classic 2-D color photographs, novel spectral domain optical coherence tomography (SDOCT) imaging systems can provide 3-D images of intra-retinal structures. In adults, tabletop SDOCT provides significantly more useful diagnostic information and is now a standard for the diagnosis and management of retinal diseases. Our preliminary studies based on handheld SDOCT (HH-SDOCT) snapshots of neonatal retina have already provided some unique and previously unseen information about disease progression in young children. However, due to the infant's head/eye motion, it is extremely cumbersome to effectively image a complete 3-D tomographic view of the macula in young, awake children and accurately measure and quantify disease biomarkers. Our long-term goal is to improve the vision outcomes of at-risk young children with ocular diseases through earlier and better-directed therapy. To achieve this goal, we will take advantage of recent advances in image processing and optics as an integrated technology to capture 3-D retinal images with higher resolution and better motion stability compared to any previous imaging technique, which will ultimately provide quantitative measurements of novel imaging biomarkers of the onset and progression of young children's ophthalmic diseases. We will achieve our objectives by pursuit of the following three specific aims: Aim 1: Develop hardware to customize the handheld SDOCT and Doppler-SDOCT systems for retinal imaging of non- sedated young children. Aim 2: Develop software to control the hardware in Aim 1 and to automatically analyze the captured images for detecting imaging biomarkers of the onset and progression of retinal diseases in young children. Aim 3: Perform a pilot study in adults and young children. Evaluate, provide feedback, and improve the performance of methodologies in Aims 1&2, and then test the utility and validity of images and measurements compared to conventional diagnostic methods. The results of this study have the potential to provide practical diagnostic tools and methodologies that will revolutionize the management of pediatric ocular diseases. This contribution would be significant as the first step in a continuum of research leading to better-directed therapy of ocular diseases in young children based on accurate quantitative measurement of disease imaging biomarkers and accurate staging of foveal development.