Portable Motion Compensated SDOCT System for Imaging Young Children

用于幼儿成像的便携式运动补偿 SDOCT 系统

• 批准号: 8404016
• 负责人: Sina Farsiu
• 金额: $ 18.18万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8404016
• 关键词: 3-Dimensional; Adult; Age related macular degeneration; Animal Model; Basic Science; Biological Markers; Blindness; Blood Vessels; Cardiovascular Diseases; Caring; Child; Childhood; Clinical Sciences; Color; Computer software; Development; Diagnostic; Diagnostic Procedure; Disease; Disease Progression; Eye; Eye diseases; Feedback; Goals; Hand; Head; Image; Imaging Device; Imaging Techniques; Infant; Lead; Measurement; Measures; Methodology; Monitor; Morphology; Motion; Neonatal; Neurologic; Optical Coherence Tomography; Optics; Outcome; Pathologic Neovascularization; Performance; Pharmacotherapy; Pilot Projects; Population; Positioning Attribute; Process; Research; Research Personnel; Resolution; Retina; Retinal; Retinal Diseases; Retinopathy of Prematurity; Risk; Staging; Structure; System; Technology; Testing; Three-Dimensional Image; Vision; abstracting; awake; base; cost; cost effective; diagnosis standard; image processing; improved; innovation; macula; novel; retina blood vessel structure; screening; software development; tool; young adult

Abstract Eye diseases of young children, if not detected and treated early, can lead to serious vision loss and even blindness. Currently, retinal diseases in young children are mainly recorded and monitored by color photographs, even though they provide limited information about ophthalmic disease processes and mechanisms. As an alternative to the classic 2-D color photographs, novel spectral domain optical coherence tomography (SDOCT) imaging systems can provide 3-D images of intra-retinal structures. In adults, tabletop SDOCT provides significantly more useful diagnostic information and is now a standard for the diagnosis and management of retinal diseases. Our preliminary studies based on handheld SDOCT (HH-SDOCT) snapshots of neonatal retina have already provided some unique and previously unseen information about disease progression in young children. However, due to the infant's head/eye motion, it is extremely cumbersome to effectively image a complete 3-D tomographic view of the macula in young, awake children and accurately measure and quantify disease biomarkers. Our long-term goal is to improve the vision outcomes of at-risk young children with ocular diseases through earlier and better-directed therapy. To achieve this goal, we will take advantage of recent advances in image processing and optics as an integrated technology to capture 3-D retinal images with higher resolution and better motion stability compared to any previous imaging technique, which will ultimately provide quantitative measurements of novel imaging biomarkers of the onset and progression of young children's ophthalmic diseases. We will achieve our objectives by pursuit of the following three specific aims: Aim 1: Develop hardware to customize the handheld SDOCT and Doppler-SDOCT systems for retinal imaging of non- sedated young children. Aim 2: Develop software to control the hardware in Aim 1 and to automatically analyze the captured images for detecting imaging biomarkers of the onset and progression of retinal diseases in young children. Aim 3: Perform a pilot study in adults and young children. Evaluate, provide feedback, and improve the performance of methodologies in Aims 1&2, and then test the utility and validity of images and measurements compared to conventional diagnostic methods. The results of this study have the potential to provide practical diagnostic tools and methodologies that will revolutionize the management of pediatric ocular diseases. This contribution would be significant as the first step in a continuum of research leading to better-directed therapy of ocular diseases in young children based on accurate quantitative measurement of disease imaging biomarkers and accurate staging of foveal development.

抽象的 幼儿的眼部疾病，如果未发现和早期治疗，可能会导致严重的视力丧失和 甚至失明。目前，幼儿的视网膜疾病主要记录和监测 照片，即使它们提供了有关眼科疾病过程的有限信息和 机制。作为经典二维彩色照片的替代方案，新的光谱域光学连贯性 断层扫描（SDOCT）成像系统可以提供3D视网膜内结构的图像。在成人，桌面 SDOCT提供了更有用的诊断信息，现在是诊断和 视网膜疾病的管理。我们基于手持式SDOCT（HH-SDOCT）快照的初步研究 新生儿视网膜已经提供了一些有关疾病的独特且以前看不见的信息 幼儿的进展。但是，由于婴儿的头部/眼睛运动，非常麻烦 有效地图像年轻，清醒儿童和准确的黄斑的完整3-D断层镜头图像 测量和量化疾病生物标志物。 我们的长期目标是改善高风险的眼部疾病的视力结果 通过较早和更好的方向疗法。为了实现这一目标，我们将利用最近的进步 图像处理和光学作为一项集成技术，可捕获具有更高分辨率的3-D视网膜图像 与以前的任何成像技术相比，更好的运动稳定性最终将提供 新型成像生物标志物的定量测量和幼儿发展的生物标志物 眼科疾病。我们将通过追求以下三个特定目标来实现我们的目标：目标1： 开发硬件来自定义手持式SDOCT和多普勒 - sDOCT系统，以进行视网膜成像 镇静的幼儿。 AIM 2：开发软件以控制AIM 1中的硬件并自动 分析捕获的图像，以检测视网膜疾病发作和进展的成像生物标志物 在幼儿。 AIM 3：对成人和幼儿进行试点研究。评估，提供反馈，以及 提高目标1和2中方法论的性能，然后测试图像的效用和有效性和有效性 与常规诊断方法相比，测量值。 这项研究的结果有可能提供实用的诊断工具和方法论 将彻底改变小儿眼疾病的管理。这项贡献将是重要的 连续研究的第一步，导致幼儿的眼科疗法更好地指导的治疗 基于对疾病成像生物标志物的准确定量测量，并准确地分期 发展。