Portable Motion Compensated SDOCT System for Imaging Young Children

用于幼儿成像的便携式运动补偿 SDOCT 系统

• 批准号: 8404016
• 负责人: Sina Farsiu
• 金额: $ 18.18万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8404016
• 关键词: 3-Dimensional; Adult; Age related macular degeneration; Animal Model; Basic Science; Biological Markers; Blindness; Blood Vessels; Cardiovascular Diseases; Caring; Child; Childhood; Clinical Sciences; Color; Computer software; Development; Diagnostic; Diagnostic Procedure; Disease; Disease Progression; Eye; Eye diseases; Feedback; Goals; Hand; Head; Image; Imaging Device; Imaging Techniques; Infant; Lead; Measurement; Measures; Methodology; Monitor; Morphology; Motion; Neonatal; Neurologic; Optical Coherence Tomography; Optics; Outcome; Pathologic Neovascularization; Performance; Pharmacotherapy; Pilot Projects; Population; Positioning Attribute; Process; Research; Research Personnel; Resolution; Retina; Retinal; Retinal Diseases; Retinopathy of Prematurity; Risk; Staging; Structure; System; Technology; Testing; Three-Dimensional Image; Vision; abstracting; awake; base; cost; cost effective; diagnosis standard; image processing; improved; innovation; macula; novel; retina blood vessel structure; screening; software development; tool; young adult

Abstract Eye diseases of young children, if not detected and treated early, can lead to serious vision loss and even blindness. Currently, retinal diseases in young children are mainly recorded and monitored by color photographs, even though they provide limited information about ophthalmic disease processes and mechanisms. As an alternative to the classic 2-D color photographs, novel spectral domain optical coherence tomography (SDOCT) imaging systems can provide 3-D images of intra-retinal structures. In adults, tabletop SDOCT provides significantly more useful diagnostic information and is now a standard for the diagnosis and management of retinal diseases. Our preliminary studies based on handheld SDOCT (HH-SDOCT) snapshots of neonatal retina have already provided some unique and previously unseen information about disease progression in young children. However, due to the infant's head/eye motion, it is extremely cumbersome to effectively image a complete 3-D tomographic view of the macula in young, awake children and accurately measure and quantify disease biomarkers. Our long-term goal is to improve the vision outcomes of at-risk young children with ocular diseases through earlier and better-directed therapy. To achieve this goal, we will take advantage of recent advances in image processing and optics as an integrated technology to capture 3-D retinal images with higher resolution and better motion stability compared to any previous imaging technique, which will ultimately provide quantitative measurements of novel imaging biomarkers of the onset and progression of young children's ophthalmic diseases. We will achieve our objectives by pursuit of the following three specific aims: Aim 1: Develop hardware to customize the handheld SDOCT and Doppler-SDOCT systems for retinal imaging of non- sedated young children. Aim 2: Develop software to control the hardware in Aim 1 and to automatically analyze the captured images for detecting imaging biomarkers of the onset and progression of retinal diseases in young children. Aim 3: Perform a pilot study in adults and young children. Evaluate, provide feedback, and improve the performance of methodologies in Aims 1&2, and then test the utility and validity of images and measurements compared to conventional diagnostic methods. The results of this study have the potential to provide practical diagnostic tools and methodologies that will revolutionize the management of pediatric ocular diseases. This contribution would be significant as the first step in a continuum of research leading to better-directed therapy of ocular diseases in young children based on accurate quantitative measurement of disease imaging biomarkers and accurate staging of foveal development.

抽象的 幼儿的眼部疾病如果不及早发现和治疗，可能会导致严重的视力丧失和 甚至失明。目前，幼儿视网膜疾病主要通过颜色进行记录和监测 照片，尽管它们提供了有关眼科疾病过程的有限信息和 机制。作为经典二维彩色照片的替代方案，新颖的谱域光学相干性 断层扫描 (SDOCT) 成像系统可以提供视网膜内结构的 3D 图像。成人，桌面 SDOCT 提供了明显更有用的诊断信息，现已成为诊断和治疗的标准 视网膜疾病的管理。我们基于手持式 SDOCT (HH-SDOCT) 快照的初步研究 新生儿视网膜已经提供了一些独特的、以前未见过的有关疾病的信息 幼儿的进展。然而，由于婴儿的头部/眼睛运动，因此非常麻烦 有效地对年轻、清醒的儿童的黄斑进行完整的 3D 断层扫描视图成像，并且准确 测量和量化疾病生物标志物。 我们的长期目标是改善患有眼部疾病的高危幼儿的视力结果 通过更早、更有针对性的治疗。为了实现这一目标，我们将利用最新的进展 图像处理和光学作为集成技术来捕获更高分辨率的 3D 视网膜图像 与之前的任何成像技术相比，具有更好的运动稳定性，这最终将提供 幼儿疾病发病和进展的新型成像生物标志物的定量测量 眼科疾病。我们将通过追求以下三个具体目标来实现我们的目标： 目标 1： 开发硬件来定制手持式 SDOCT 和多普勒-SDOCT 系统，用于非视网膜成像 给幼儿服用镇静剂。目标 2：开发软件来控制目标 1 中的硬件并自动 分析捕获的图像以检测视网膜疾病发生和进展的成像生物标志物 在幼儿中。目标 3：在成人和幼儿中进行试点研究。评估、提供反馈并 提高目标 1 和 2 中方法的性能，然后测试图像的实用性和有效性 与传统诊断方法相比的测量。 这项研究的结果有可能提供实用的诊断工具和方法， 将彻底改变小儿眼科疾病的治疗。这一贡献将意义重大，因为 旨在更好地治疗幼儿眼部疾病的连续研究的第一步 基于疾病影像生物标志物的准确定量测量和中心凹的准确分期 发展。