CRISP III - Kansas Polycystic Kidney Imaging Program Supplemental Request

CRISP III - 堪萨斯州多囊肾成像计划补充请求

基本信息

  • 批准号:
    9269449
  • 负责人:
  • 金额:
    $ 6万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-06-01 至 2017-05-30
  • 项目状态:
    已结题

项目摘要

Autosomal dominant polycystic kidney disease (ADPKD) is a major cause of morbidity and the fourth leading cause of ESRD in the world, affecting more than 500,000 U.S. citizens. Researchers at the University of Alabanna, Emory University, University of Kansas, Mayo Clinic and Washington University joined together in 2000 to create the Consortium for Radiologic Studies of Polycystic Kidney Disease (CRISPI) and in 2006 ncluded the University of Pittsburgh in place of Washington University for CRISP II. The primary objectives of CRISPI and II were to: establish accurate, reliable and reproducible magnetic resonance based measurements of total kidney volume (TKV), liver cyst volume (LCV), renal blood flow (RBF), and patterns of cyst growth and expansion. Based on 7.3 years of longitudinal followup in 200 CRISP l/ll participants, we can now: 1) establish an unequivocal relationship between TKV and qualitative (patient reported outcomes) and quantitative (renal insufficiency) end-points; as well as 2) identify potential modifiable risk factors associating with TKV and LCV for intervention studies. TKV ultimately may be used as a surrogate marker of disease progression in clinical trials. The goals of CRISPIN extend the observations of CRlSPI/ll. The overarching Aim for CRISP III is to develop and enhance prediction models that best predict renal nsufficiency in ADPKD. Specifically, Aim 1: Extend the serial quantification of TKV and LCV to develop and test new models for predicting the risk of developing renal insufficiency. Aim 2: Determine the extent to which age and sex-adjusted measurements of RBF predict the rate of change in TKV and determine if RBF and TKV independently predict the risk of developing renal insufficiency. Aim 3: Develop methods to quantify the influence of renal cyst number, volume, and topography at baseline on the subsequent course of TKV and GFR and the risk of developing renal insufficiency. Aim 4: Expand and analyze CRISP biological samples collected in NIDDK repositories to improve genotype/phenotype and biomarker studies, and facilitate ancillary studies. Aim 5. Test the feasibility and efficacy of intensive dietary counseling in modifying the fixed pattern of sodium intake observed in CRISP and determine if this change alters the rate of TKV change. RELEVANCE (See instructions): The results of these studies will impact the lives of patients with ADPKD. Developing predictive markers of disease severity early, prior to loss of renal insufficiency will result in increased life expectancy and improved quality of life in patients with ADPKD.
常染色体显性多囊肾病(ADPKD)是发病率的主要原因和第四大

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Autosomal dominant polycystic kidney disease and transplantation.
  • DOI:
  • 发表时间:
    2009-12
  • 期刊:
  • 影响因子:
    1.1
  • 作者:
    M. Niemczyk;S. Niemczyk;L. Pączek
  • 通讯作者:
    M. Niemczyk;S. Niemczyk;L. Pączek
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Alan S Yu其他文献

Alan S Yu的其他文献

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{{ truncateString('Alan S Yu', 18)}}的其他基金

Biomedical Research Core 3 - Clinical Research Core
生物医学研究核心 3 - 临床研究核心
  • 批准号:
    10475048
  • 财政年份:
    2020
  • 资助金额:
    $ 6万
  • 项目类别:
Biomedical Research Core 3 - Clinical Research Core
生物医学研究核心 3 - 临床研究核心
  • 批准号:
    10214616
  • 财政年份:
    2020
  • 资助金额:
    $ 6万
  • 项目类别:
Biomedical Research Core 3 - Clinical Research Core
生物医学研究核心 3 - 临床研究核心
  • 批准号:
    10059768
  • 财政年份:
    2020
  • 资助金额:
    $ 6万
  • 项目类别:
Biomedical Research Core 3 - Clinical Research Core
生物医学研究核心 3 - 临床研究核心
  • 批准号:
    10686076
  • 财政年份:
    2020
  • 资助金额:
    $ 6万
  • 项目类别:
Role of claudin-2 in Calcium Homeostasis and Kidney Stone Disease
Claudin-2 在钙稳态和肾结石疾病中的作用
  • 批准号:
    10238078
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Role of claudin-2 in Calcium Homeostasis and Kidney Stone Disease
Claudin-2 在钙稳态和肾结石疾病中的作用
  • 批准号:
    10020951
  • 财政年份:
    2019
  • 资助金额:
    $ 6万
  • 项目类别:
Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) IV: Prognosis for End-Stage Renal Disease and Biomarker Validation
多囊肾病放射影像研究联盟 (CRISP) IV:终末期肾病的预后和生物标志物验证
  • 批准号:
    9906761
  • 财政年份:
    2017
  • 资助金额:
    $ 6万
  • 项目类别:
Randomized, controlled pilot study of nicotinamide in polycystic kidney disease
烟酰胺治疗多囊肾病的随机对照试验研究
  • 批准号:
    8807460
  • 财政年份:
    2015
  • 资助金额:
    $ 6万
  • 项目类别:
Randomized, controlled pilot study of nicotinamide in polycystic kidney disease
烟酰胺治疗多囊肾病的随机对照初步研究
  • 批准号:
    9136856
  • 财政年份:
    2015
  • 资助金额:
    $ 6万
  • 项目类别:
Structure-Function Studies of Tight Junction Membrane Proteins
紧密连接膜蛋白的结构-功能研究
  • 批准号:
    8152114
  • 财政年份:
    2010
  • 资助金额:
    $ 6万
  • 项目类别:

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激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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