CRISP III - Kansas Polycystic Kidney Imaging Program Supplemental Request
CRISP III - 堪萨斯州多囊肾成像计划补充请求
基本信息
- 批准号:9269449
- 负责人:
- 金额:$ 6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-06-01 至 2017-05-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgeAncillary StudyAutosomal Dominant Polycystic KidneyBiologicalBiological MarkersCharacteristicsClinicClinicalClinical DataClinical TrialsComputer Retrieval of Information on Scientific Projects DatabaseCounselingCystCystic kidneyDNADataData AnalysesDevelopmentDietDisease ProgressionEnd stage renal failureFamily memberFundingGeneticGenetic studyGenotypeGoalsGrowthHepatic CystImageIndividualInstructionIntakeInterventionIntervention StudiesKansasKidneyKidney DiseasesKidney FailureLife ExpectancyLiverMagnetic ResonanceMagnetic Resonance ImagingMeasurementMethodsModelingMorbidity - disease rateNational Institute of Diabetes and Digestive and Kidney DiseasesNatureOther GeneticsParticipantPatient Outcomes AssessmentsPatientsPatternPhenotypePilot ProjectsPolycystic Kidney DiseasesPopulationPredictive ValuePrincipal InvestigatorProteomicsQuality of lifeRenal Blood FlowRenal functionResearch PersonnelResourcesRiskRisk FactorsRoleSamplingSensitivity and SpecificitySeveritiesSeverity of illnessSodiumSurrogate MarkersTestingUniversitiesWashingtonbasefollow-upgenetic risk factorimprovedkidney imagingmodifiable riskpredictive markerprogramsrate of changerepositoryserological markersexurinary
项目摘要
Autosomal dominant polycystic kidney disease (ADPKD) is a major cause of morbidity and the fourth leading
cause of ESRD in the world, affecting more than 500,000 U.S. citizens. Researchers at the University of
Alabanna, Emory University, University of Kansas, Mayo Clinic and Washington University joined together in
2000 to create the Consortium for Radiologic Studies of Polycystic Kidney Disease (CRISPI) and in 2006
ncluded the University of Pittsburgh in place of Washington University for CRISP II. The primary objectives
of CRISPI and II were to: establish accurate, reliable and reproducible magnetic resonance based
measurements of total kidney volume (TKV), liver cyst volume (LCV), renal blood flow (RBF), and patterns of
cyst growth and expansion. Based on 7.3 years of longitudinal followup in 200 CRISP l/ll participants, we
can now: 1) establish an unequivocal relationship between TKV and qualitative (patient reported outcomes)
and quantitative (renal insufficiency) end-points; as well as 2) identify potential modifiable risk factors
associating with TKV and LCV for intervention studies. TKV ultimately may be used as a surrogate marker
of disease progression in clinical trials. The goals of CRISPIN extend the observations of CRlSPI/ll. The
overarching Aim for CRISP III is to develop and enhance prediction models that best predict renal
nsufficiency in ADPKD. Specifically, Aim 1: Extend the serial quantification of TKV and LCV to develop and
test new models for predicting the risk of developing renal insufficiency. Aim 2: Determine the extent to which
age and sex-adjusted measurements of RBF predict the rate of change in TKV and determine if RBF and
TKV independently predict the risk of developing renal insufficiency. Aim 3: Develop methods to quantify the
influence of renal cyst number, volume, and topography at baseline on the subsequent course of TKV and
GFR and the risk of developing renal insufficiency. Aim 4: Expand and analyze CRISP biological samples
collected in NIDDK repositories to improve genotype/phenotype and biomarker studies, and facilitate
ancillary studies. Aim 5. Test the feasibility and efficacy of intensive dietary counseling in modifying the fixed
pattern of sodium intake observed in CRISP and determine if this change alters the rate of TKV change.
RELEVANCE (See instructions):
The results of these studies will impact the lives of patients with ADPKD. Developing predictive markers of
disease severity early, prior to loss of renal insufficiency will result in increased life expectancy and improved
quality of life in patients with ADPKD.
常染色体显性遗传性多囊肾病(ADPKD)是发病的主要原因,也是第四大病因。
这是世界上最严重的终末期肾病,影响了50多万美国公民。大学的研究人员
安娜,埃默里大学,堪萨斯大学,马约诊所和华盛顿大学联合起来,
2000年创建了多囊肾病放射学研究联盟(CRISPI),2006年
包括匹兹堡大学代替华盛顿大学参加CRISP II。主要目标
CRISPI和II的目的是:建立准确,可靠和可重复的磁共振基础
测量肾脏总体积(TKV)、肝囊肿体积(LCV)、肾血流量(RBF)和
囊肿生长和扩张。基于对200名CRISP l/ll参与者进行的7.3年纵向随访,我们
现在可以:1)确定TKV和定性(患者报告的结局)之间的明确关系
和定量(肾功能不全)终点;以及2)确定潜在的可改变的风险因素
与TKV和LCV联合进行干预研究。TKV最终可用作替代标记物
临床试验中的疾病进展。CRISPIN的目标扩展了CRISPI/II的观察。的
CRISP III的总体目标是开发和增强预测模型,
ADPKD的不足。具体而言,目标1:扩展TKV和LCV的系列定量,
测试预测肾功能不全风险的新模型。目标2:确定
经年龄和性别调整的RBF测量值可预测TKV的变化率,并确定RBF和
TKV可独立预测发生肾功能不全的风险。目标3:制定方法,
基线时肾囊肿数量、体积和地形对TKV后续过程的影响,
GFR和肾功能不全的风险。目的4:扩展和分析CRISP生物样品
收集在NIDDK储存库中,以改善基因型/表型和生物标志物研究,并促进
辅助研究。目标5。测试强化饮食咨询在修改固定饮食中的可行性和有效性
CRISP中观察到的钠摄入模式,并确定该变化是否改变TKV变化率。
相关性(参见说明):
这些研究的结果将影响ADPKD患者的生活。开发预测标记物
疾病严重程度早,肾功能不全之前的损失将导致预期寿命的增加和改善
ADPKD患者的生活质量。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Autosomal dominant polycystic kidney disease and transplantation.
- DOI:
- 发表时间:2009-12
- 期刊:
- 影响因子:1.1
- 作者:M. Niemczyk;S. Niemczyk;L. Pączek
- 通讯作者:M. Niemczyk;S. Niemczyk;L. Pączek
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Alan S Yu其他文献
Alan S Yu的其他文献
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{{ truncateString('Alan S Yu', 18)}}的其他基金
Biomedical Research Core 3 - Clinical Research Core
生物医学研究核心 3 - 临床研究核心
- 批准号:
10475048 - 财政年份:2020
- 资助金额:
$ 6万 - 项目类别:
Biomedical Research Core 3 - Clinical Research Core
生物医学研究核心 3 - 临床研究核心
- 批准号:
10214616 - 财政年份:2020
- 资助金额:
$ 6万 - 项目类别:
Biomedical Research Core 3 - Clinical Research Core
生物医学研究核心 3 - 临床研究核心
- 批准号:
10059768 - 财政年份:2020
- 资助金额:
$ 6万 - 项目类别:
Biomedical Research Core 3 - Clinical Research Core
生物医学研究核心 3 - 临床研究核心
- 批准号:
10686076 - 财政年份:2020
- 资助金额:
$ 6万 - 项目类别:
Role of claudin-2 in Calcium Homeostasis and Kidney Stone Disease
Claudin-2 在钙稳态和肾结石疾病中的作用
- 批准号:
10238078 - 财政年份:2019
- 资助金额:
$ 6万 - 项目类别:
Role of claudin-2 in Calcium Homeostasis and Kidney Stone Disease
Claudin-2 在钙稳态和肾结石疾病中的作用
- 批准号:
10020951 - 财政年份:2019
- 资助金额:
$ 6万 - 项目类别:
Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) IV: Prognosis for End-Stage Renal Disease and Biomarker Validation
多囊肾病放射影像研究联盟 (CRISP) IV:终末期肾病的预后和生物标志物验证
- 批准号:
9906761 - 财政年份:2017
- 资助金额:
$ 6万 - 项目类别:
Randomized, controlled pilot study of nicotinamide in polycystic kidney disease
烟酰胺治疗多囊肾病的随机对照试验研究
- 批准号:
8807460 - 财政年份:2015
- 资助金额:
$ 6万 - 项目类别:
Randomized, controlled pilot study of nicotinamide in polycystic kidney disease
烟酰胺治疗多囊肾病的随机对照初步研究
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9136856 - 财政年份:2015
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Structure-Function Studies of Tight Junction Membrane Proteins
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8152114 - 财政年份:2010
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$ 6万 - 项目类别:
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