Molecular Basis of Bioelectronic Medicine

生物电子医学的分子基础

• 批准号: 9071799
• 负责人: Kevin J Tracey
• 金额: $ 51.42万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9071799
• 关键词: Anti-Inflammatory Agents; Anti-inflammatory; Autoimmune Diseases; Biology; Cytokine Gene; Data; Devices; Disease; Electronics; Etiology; Funding; Future; Gene Expression; Immune response; Infection; Inflammation; Inflammation Mediators; Inflammatory; Injury; Laboratories; Maps; Mediating; Medicine; Modality; Molecular; Molecular Target; National Institute of General Medical Sciences; Neurotransmitters; Prevention; Reflex action; Regulation; Reperfusion Injury; Research Personnel; Research Support; Sepsis; Shock; Sterility; Therapeutic; Work; base; cytokine; neural circuit; public health relevance; therapy development

 DESCRIPTION (provided by applicant): Inflammation, mediated by the immune response to infection and sterile injury, is a major underlying cause of disease. Advances in understanding the molecular mechanisms of inflammation hold promise for developing future therapies for severe sepsis, shock, ischemia reperfusion injury, autoimmune diseases, and other debilitating diseases of national importance. Research supported by the NIGMS in the principle investigator's lab has revealed mechanisms to control inflammation by identifying and targeting specific cytokines, and by mapping and targeting specific neural circuits that control their activity. This work has now progressed to launching a new field, termed "bioelectronic medicine," which holds promise as strategy to develop therapies using electronic devices to target anti-inflammatory neural circuits. The present proposal seeks to understand unanswered questions about the molecular mechanisms controlling inflammation as derived from three existing RO1 funded projects in the PI's laboratory. The first is to understand the identity and mechanisms of the reflex neural circuits that control immune responses. The second is to understand the biology of cytokine mediators of inflammation that are necessary and sufficient for disease causation. And the third is to understand the molecular mechanisms that regulate cytokine release under the influence of neurotransmitters, including regulation of cytokine gene expression and inflammasome activity. The successful completion of this work will provide significant new data necessary to develop therapeutic modalities for the prevention and treatment of inflammation using bioelectronic devices.

 描述（由申请人提供）：由对感染和无菌损伤的免疫反应介导的炎症是疾病的主要根本原因。了解炎症分子机制的进展有望开发未来治疗严重败血症、休克、缺血再灌注损伤、自身免疫性疾病和其他国家重要衰弱性疾病的疗法。由首席研究员实验室的 NIGMS 支持的研究揭示了通过识别和针对特定细胞因子以及通过绘制和针对控制其活动的特定神经回路来控制炎症的机制。这项工作现已进展到推出一个名为“生物电子医学”的新领域，该领域有望作为开发使用电子设备针对抗炎神经回路的疗法的策略。本提案旨在了解有关控制炎症的分子机制的未解答问题，这些问题源自 PI 实验室现有的三个 RO1 资助的项目。首先是了解控制免疫反应的反射神经回路的身份和机制。第二个是了解炎症细胞因子介质的生物学，这对于疾病的致病是必要且充分的。第三是了解神经递质影响下调节细胞因子释放的分子机制，包括细胞因子基因表达和炎症小体活性的调节。这项工作的成功完成将为开发使用生物电子设备预防和治疗炎症的治疗方式提供必要的重要新数据。