VAGUS NERVE STIMULATION IN RHEUMATOID ARTHRITIS (VANSRA)

迷走神经刺激治疗类风湿性关节炎 (VANSRA)

• 批准号: 7951920
• 负责人: Kevin J Tracey
• 金额: $ 0.29万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951920
• 关键词: Adverse effects; Affect; Autonomic nervous system; Cardiovascular Diseases; Chronic; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Disease; Disease Marker; Ear; Functional disorder; Funding; Goals; Grant; Inflammation; Institution; Joints; Measures; Morbidity - disease rate; Nervous System Physiology; Organ; Outcome; Research; Research Personnel; Resources; Rheumatoid Arthritis; Risk; Source; United States National Institutes of Health; Vagus nerve structure; heart rate variability; human data; inflammatory marker; mortality; vagus nerve stimulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to examine the short-term effects of vagus nerve stimulation (VNS) by auricular stimulation (stimulation of the auricular branch of the vagus nerve which innervates the ear) in rheumatoid arthritis (RA). RA is characterized by a chronic systemic inflammation affecting the joints but also carries an increased risk for extra-articular manifestations as well as other organ manifestations such as cardiovascular disease, which significantly contributes to morbidity and mortality in this disorder. Previously, we have studied the relationship between RA and autonomic nervous system function (ANS). Preliminary human data from this study shows that there is an association between ANS dysfunction, measured as heart rate variability and inflammatory markers in RA. Ultimately the goal of this study is to develop new treatment concepts by modulating the ANS in RA with a beneficial effect on disease markers and outcome while minimizing side-effects.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是检查迷走神经刺激（VNS）的短期效果，通过耳刺激（刺激迷走神经的耳分支，支配耳朵）在类风湿性关节炎（RA）。RA的特征在于影响关节的慢性全身性炎症，但也具有关节外表现以及其他器官表现如心血管疾病的增加的风险，这显著地导致该疾病的发病率和死亡率。 以前，我们已经研究了RA和自主神经系统功能（ANS）之间的关系。这项研究的初步人类数据显示，在RA中，ANS功能障碍（以心率变异性和炎症标志物测量）之间存在关联。本研究的最终目标是通过调节RA中的ANS来开发新的治疗概念，对疾病标志物和结果产生有益影响，同时最大限度地减少副作用。