Massive scale electrical neural recordings in vivo using commercial ROIC chips

使用商用 ROIC 芯片进行大规模体内电神经记录

• 批准号: 9146823
• 负责人: Konrad P. Kording
• 金额: $ 56.52万
• 依托单位: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9146823
• 关键词: Address; Affect; Amplifiers; Area; Back; Behavior; Biological Sciences; Brain; Caliber; Data; Data Analyses; Development; Devices; Educational process of instructing; Electrodes; Electrolytes; Electronics; Electrophysiology (science); Elements; Engineering; Equipment; Figs - dietary; Fostering; Frequencies; Future; Glass; Goals; Gold; Growth; Hand; Health; Human; Image; Individual; Laws; Measures; Mechanics; Metals; Methods; Mission; Neurons; Neurosciences; Noise; Partner in relationship; Performance; Physics; Physiology; Plant Roots; Polishes; Prosthesis; Public Health; Reading; Research; Rodent; Scheme; Shapes; Signal Transduction; Speed; Surface; System; Techniques; Technology; Work; base; brain machine interface; computational neuroscience; cost; design; human subject; improved; in vivo; innovation; materials science; neuronal circuitry; neurotransmission; novel diagnostics; novel therapeutics; programs; relating to nervous system; research study; response; success; time use; tool

DESCRIPTION (provided by applicant): Current scaling behavior in electrical recording is dominated by the difficulty of fabricating systems with many high bandwidth channels. The objective of our research is a radically new and innovative approach of fabricating massive scale electrical recording setups. In our approach, a polished bundle of insulated metal wires (that act as recording electrodes) are pushed mechanically on the surface of a commercial amplifier chip used for high-speed infrared imaging. This allows us to tie into the massive progress happening in the imaging field. The long term goal of our research is to enable a paradigm shift, making the recording of massive amounts of neurons a cheap possibility. Our approach combines electrode design, innovative methods for electrical connections, and off-the-shelf read out integrated circuits (ROICs). The approach is innovative, because it uses a unique combination of techniques to produce a device that allows orders of magnitude more channels to be recorded at a fraction of the cost with unrivalled potential for future growth. The proposed research is significant, because it is a radical departure from current ways of conducting electrophysiological experiments. The far larger numbers of electrical channels promise to enable a broad range of new experiments, ever boosted by future improvements in imaging chip development. But above all, the planned methods should become compatible with recording from human subjects in the context of brain machine interfaces.

描述（由申请人提供）：电记录中的电流缩放行为由制造具有许多高带宽通道的系统的困难所支配。我们的研究目标是一种全新的创新方法，制造大规模的电子记录装置。在我们的方法中，一束抛光的绝缘金属线（作为记录电极）被机械地推到用于高速红外成像的商业放大器芯片的表面上。这使我们能够与成像领域发生的巨大进步联系起来。我们研究的长期目标是实现范式转变，使记录大量神经元成为一种廉价的可能性。我们的方法结合了电极设计、创新的电连接方法和现成的读出集成电路（ROIC）。这种方法是创新的，因为它使用了一种独特的技术组合来生产一种设备，这种设备允许以一小部分成本记录更多数量级的通道，并具有无与伦比的未来增长潜力。这项研究意义重大，因为它彻底背离了目前进行电生理实验的方式。更大数量的电通道有望实现广泛的新实验，这将受到成像芯片开发的未来改进的推动。但最重要的是，计划中的方法应该与脑机接口背景下的人类受试者的记录兼容。