Pilot 2: Watchful Living: A lifestyle intervention for black prostate cancer patients on active surveillance and their partners

试点 2：警惕的生活：对接受主动监测的黑人前列腺癌患者及其伴侣进行生活方式干预

• 批准号: 9418230
• 负责人: Dalnim Cho
• 金额: $ 4.36万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-22 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9418230
• 关键词: Address; Anxiety; Area; Basen; Behavior; Behavioral; Biometry; Body mass index; Cancer Center; Cancer Intervention; Cancer Patient; Cancer Survivor; Caregivers; Chronic; Chronic Disease; Clinical; Collaborations; Continuity of Patient Care; Counseling; Couples; Data; Detection; Diagnosis; Diet; Dietitian; Disease; Evaluation; Feedback; Focus Groups; Funding; Goals; Health; Home environment; Hospitals; Incidence; Inflammation; Inflammatory; Intake; Intervention; Life Style; Malignant Neoplasms; Malignant neoplasm of prostate; Monitor; Morbidity - disease rate; Participant; Pathway interactions; Patient Recruitments; Patients; Physical activity; Play; Population; Process; Prostate-Specific Antigen; Quality of life; Recruitment Activity; Research; Research Personnel; Risk; Role; Second Primary Cancers; Social support; Source; Spouses; Telephone; Testing; Therapeutic Intervention; Universities; University of Texas M D Anderson Cancer Center; base; behavior change; cancer care; cancer health disparity; clinical biomarkers; clinically significant; comorbidity; coping; design; exercise prescription; experience; fruits and vegetables; improved; inflammatory marker; innovation; lifestyle intervention; men; mortality; nutrition; prevent; programs; satisfaction; screening; tertiary prevention

PROJECT SUMMARY/ABSTRACT The burden of prostate cancer in the U.S. is large: an estimated 14% of men will be diagnosed with prostate cancer during their lifetime. There are approximately three million prostate cancer survivors in the U.S., and the burden is highest among black men, for whom incidence and mortality rates are 169.4 and 69.0 per 100,000, respectively. The introduction of prostate-specific antigen screening has resulted in detection of more cases of prostate cancer, although many of these cases are asymptomatic and may not progress to clinical significance. Active surveillance is a management option for low-risk prostate cancer patients, during which the disease is actively monitored. Active surveillance patients are an ideal population for lifestyle interventions, which may improve diet and physical activity, reduce body mass index, and improve clinical biomarkers, thus reducing risk of other chronic conditions and second primary cancers and improving patients' quality of life. Thus far, several lifestyle interventions for patients undergoing active surveillance have had positive results; however, none have targeted spouses or partners, or black men, in their design and implementation. The proposed study seeks to pilot test Watchful Living, an innovative, culturally-relevant social support lifestyle intervention during active surveillance for black prostate cancer patients and their partners. Our specific aims are: 1) To determine the feasibility of recruiting and implementing a lifestyle intervention during active surveillance for prostate cancer patients and their partners, 2) To evaluate preliminary efficacy of an active surveillance lifestyle intervention in improving diet, physical activity, quality of life, and inflammation at the end of the study (Month 6), and 3) To conduct a process evaluation of the active surveillance lifestyle intervention. We will recruit 40 patient-partner dyads from MD Anderson Cancer Center and Lyndon B. Johnson Hospital, who will receive dyadic telephone coaching, exercise prescriptions in a home-based physical activity program, nutrition counseling with a registered dietitian, and educational handouts. Watchful Living has the potential to ultimately prevent morbidity and mortality due to prostate cancer by significantly reducing chronic diseases and second primary cancers, and improving the quality of life of black patients and their partners. Pilot funding is critical to demonstrating the feasibility and preliminary efficacy of our intervention. With this pilot data, we will apply for an R01 to adapt, implement, and evaluate the intervention on a larger scale.

项目总结/摘要 美国前列腺癌的负担很大：估计14%的男性将被诊断为前列腺癌 癌症在一生中在美国大约有300万前列腺癌幸存者，和 黑人男性的负担最重，其发病率和死亡率分别为169.4%和69.0%。 10万，分别。前列腺特异性抗原筛查的引入， 前列腺癌的病例，虽然这些病例中的许多是无症状的，可能不会进展到临床 意义积极监测是低风险前列腺癌患者的一种管理选择，在此期间， 疾病得到积极监测。主动监测患者是生活方式干预的理想人群， 这可能会改善饮食和身体活动，降低体重指数，并改善临床生物标志物，因此 降低其他慢性疾病和第二原发性癌症的风险，改善患者的生活质量。 迄今为止，对接受积极监测的患者采取的几种生活方式干预措施已取得积极成果; 然而，在设计和实施这些措施时，没有一项措施以配偶或伴侣或黑人男子为目标。的 一项拟议的研究旨在试点测试观察生活，一种创新的，与文化相关的社会支持生活方式 在积极监测期间对黑人前列腺癌患者及其伴侣进行干预。我们的具体目标 1）确定在活动期间招募和实施生活方式干预的可行性 监测前列腺癌患者及其伴侣，2）评估活性药物的初步疗效， 监测生活方式干预在改善饮食，体力活动，生活质量和炎症， 研究结束（第6个月），以及3）对主动监测生活方式进行过程评价 干预我们将从MD安德森癌症中心和林登B招募40名患者-伴侣配对。 约翰逊医院，谁将接受二元电话辅导，行使处方在家庭为基础的身体 活动计划，注册营养师的营养咨询，以及教育性讲义。关注生活 通过显著降低前列腺癌的发病率和死亡率， 慢性疾病和第二原发性癌症，并改善黑人患者及其 伙伴试点资金对于证明我们干预措施的可行性和初步功效至关重要。 有了这些试点数据，我们将申请R 01，以适应、实施和评估更大规模的干预措施。 规模