Prenatal and Early Life Antecedents of Personality: An Intergenerational Lifespan Approach

人格的产前和早期生命前因：代际寿命方法

• 批准号: 9258939
• 负责人: Angelina R Sutin
• 金额: $ 70.6万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9258939
• 关键词: Address; Adolescence; Adult; Age; Aging; Alcohol abuse; Alzheimer' s Disease; Alzheimer' s disease risk; Behavioral; Biological; Biological Factors; Biological Markers; Biological Testing; Buffers; Cardiovascular Diseases; Child; Childhood; Clinical; Cognition; Cognitive; Cognitive aging; Conceptions; Consequentialism; Crime; Data; Data Collection; Data Sources; Development; Disease; Early Intervention; Economics; Environment; Environmental Risk Factor; Exposure to; Functional disorder; Genetic; Gestational Diabetes; Goals; Health; Hypertension; Impaired cognition; Individual; Individual Differences; Inflammation; Intervention; Knowledge; Life; Life Cycle Stages; Link; Longevity; Longitudinal Studies; Maternal Behavior; Maternal Health; Measures; Mediating; Mediator of activation protein; Mental Depression; Modeling; Neighborhoods; Neurotic Disorders; Neurotics; Outcome; Outcomes Research; Parents; Pathway interactions; Personality; Personality Development; Personality Traits; Play; Pregnancy; Process; Research; Risk; Risk Factors; Role; Shapes; Smoking; Temperament; Testing; Theoretical model; Time; Work; base; cognitive development; cognitive function; cohort; disorder risk; early childhood; emotion regulation; fetal programming; healthy aging; improved; inflammatory marker; intergenerational; offspring; prenatal; psychologic; racial diversity; social deprivation; social health determinants; socioeconomics; theories; trait; young adult

Project Summary. This research takes an intergenerational lifespan perspective to the development of trait psychological functioning. There are well-documented connections between Conscientiousness and Neuroticism and aging- related outcomes: Individuals who score higher in Conscientiousness and lower in Neuroticism have lower risk of Alzheimer’s disease and greater longevity. The association between these traits and better health begins early in life and persist across the lifespan. Early interventions to promote healthier trait development will lead to broad improvements in health and well-being and ultimately better aging outcomes. Yet, little is known about the early environmental origins of these traits that would be promising targets of intervention. Likewise, relatively little is known about how biological factors contribute to trait development across the lifespan. The present research brings together three established longitudinal studies of well-characterized cohorts to identify prenatal and childhood environmental factors (broadly construed) that contribute to the development of personality, the biological mediators of these associations, and the dynamics between prenatal/childhood factors and personality on a consequential health outcome – the development and aging of cognitive functioning across the lifespan. Together, these three cohorts cover conception through older adulthood: The Longitudinal Study of Australian Children covers pregnancy through age 12, the Avon Longitudinal Study of Parents and Children covers pregnancy through young adulthood, and the Healthy Aging in Neighborhoods of Diversity across the Life Span covers middle through older adulthood. This research addresses three specific aims: (1) To identify maternal prenatal behavioral and clinical antecedents of temperament and personality traits and to test biological markers as one mechanism through which prenatal factors contribute to trait psychological functioning, (2) To identify childhood neighborhood antecedents of trait psychological functioning in childhood, adolescence, and adulthood and to test biological markers as one mechanism through which neighborhood factors contribute to trait psychological functioning, and (3) To test whether personality traits mediate and/or moderate the relation between the prenatal/childhood environment and cognitive functioning across the lifespan. The outcomes of this research will lead to new knowledge on the origins of the traits most relevant for healthy aging and suggest promising new targets for intervention.

项目摘要。 本研究从代际寿命的角度探讨了特质心理的发展 功能有充分的证据表明，责任心和神经质与衰老之间存在联系- 相关结果：在尽责性方面得分较高而在神经质方面得分较低的人， 老年痴呆症和更长寿。这些特征和更好的健康之间的联系开始于 在生命的早期，并持续整个生命周期。早期干预，以促进更健康的特质发展将导致 健康和幸福的广泛改善，最终更好的老龄化结果。然而，人们对 这些特征的早期环境起源将是有希望的干预目标。同样地， 关于生物因素如何在整个生命周期中促进性状发展，我们所知相对较少。的 目前的研究汇集了三个已建立的纵向研究的良好特征的队列，以确定 产前和儿童环境因素（广义解释），有助于发展 人格，这些协会的生物介质，以及产前/童年之间的动态 因素和个性对健康结果的影响-认知能力的发展和衰老 在整个生命周期中发挥作用。总之，这三个队列涵盖了从成年到成年的概念： 澳大利亚儿童纵向研究涵盖了怀孕到12岁，雅芳纵向研究 父母和孩子涵盖怀孕到年轻的成年，和健康老龄化的社区， 整个生命周期的多样性涵盖了中年到老年。这项研究涉及三个具体的 目的：（1）探讨气质和人格的产前行为和临床前因 性状和测试生物标记作为产前因素有助于性状的一种机制， 心理功能，（2）识别特质心理功能的童年邻里前因 在儿童期，青春期和成年期，并测试生物标志物作为一种机制， 邻里因素对特质心理功能的影响;（3）检验人格特质 调解和/或缓和产前/儿童环境和认知功能之间的关系 在整个生命周期中。这项研究的结果将导致新的知识的起源的特点最 与健康老龄化相关，并提出了有希望的新干预目标。