Physiology of Inflammatory Arthritis in High Resolution

高分辨率炎症性关节炎的生理学

• 批准号: 9389824
• 负责人: XUEDING WANG
• 金额: $ 81.78万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-06 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9389824
• 关键词: 3D ultrasound; Adjuvant Arthritis; Affect; Algorithmic Analysis; Animal Model; Arthritis; Biological Markers; Clinic; Clinical; Clinical Management; Clinical Research; Detection; Development; Devices; Disease; Early Diagnosis; Early treatment; Ensure; Feasibility Studies; Frequencies; Goals; Grant; Hand; Hemoglobin; Human; Hyperemia; Hypoxia; Image; Imaging Device; Imaging technology; Inflammation; Inflammatory; Inflammatory Arthritis; Joints; Lasers; Lead; Measures; Medical; Metabolic; Methods; Michigan; Modality; Modeling; Modification; Optics; Outcomes Research; Oxygen; Parents; Pathologic; Patients; Performance; Peripheral; Pharmacological Treatment; Phase; Physicians; Physiological; Physiology; Pilot Projects; Point-of-Care Systems; Procedures; Process; Prospective Studies; Radiology Specialty; Rattus; Reproducibility; Research; Research Personnel; Resolution; Rheumatology; Robotics; Scanning; Swelling; Synovitis; System; Technology; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Translating; Translations; Treatment outcome; Ultrasonography; Universities; base; clinical application; cost efficient; experience; experimental study; hemodynamics; human imaging; human subject; image processing; imaging biomarker; imaging modality; imaging system; interest; musculoskeletal ultrasound; novel; outcome forecast; personalized medicine; photoacoustic imaging; point of care; prototype; response; soft tissue; success; tissue biomarkers; treatment response; volunteer

Title: Physiology of Inflammatory Arthritis in High Resolution Abstract Development of new imaging technologies to identify and validate biomarkers of inflammatory arthritic disease is of broad interest and aligned with common goals of physicians, medical researchers, and scientific entities. Presenting highly sensitive optical information in subsurface tissue with spatial resolution comparable to ultrasound (US) imaging, the emerging photoacoustic (PA) imaging offers significant advantages to early diagnosis and prognosis, as well as assessing the treatment of arthritis, by providing additional new functional information about the disease activity that can be effectively combined with more established and widely accepted musculoskeletal US imaging. Our current research on arthritis patients has successfully demonstrated that a combined US-PA system is capable of identifying and characterizing inflammation in human peripheral joints, based on the detection of hemodynamic and metabolic changes, including both hyperemia and hypoxia. These are important and early physiological biomarkers of synovitis reflecting the increased metabolic demand and the relatively inadequate oxygen delivery of the inflammatory synovial tissue. Encouraged by the initial success of our study on arthritis patients, we propose to further advance the translation of US-PA dual imaging technology to clinical management of inflammatory arthritis. Our ultimate goal is to develop a cost-efficient and point-of-care joint imaging device that can enable early treatment modification and personalized medicine, changing the current procedures in rheumatology clinic. In this research, to understand the clinical value of the proposed imaging technology, we will identify a group of robust, reliably reproducible, and precise biomarkers that can reflect the early pathological changes of inflammatory arthritis and its response to treatment. The central hypothesis is that a group of 3D US and PA biomarkers that can be evaluated by the proposed imaging technology can lead to better assessment of arthritis disease state and treatment response than those evaluated by conventional 2D US imaging. To examine this hypothesis, following specific aims will be accomplished: Aim 1: Develop a method to assess inflammatory arthritis disease activity by quantifying 3D US and PA biomarkers that reflect the underlying pathological condition of specific joints Aim 2: Evaluate the performance of these biomarkers in assessing the pathological condition in local joints affected by arthritis through the study on a well-developed animal model Aim 3. Evaluate the clinical value of the identified imaging biomarkers that can be assessed by the US-PA dual-modality technology via a pilot study on patients affected by inflammatory arthritis

标题：高分辨率炎症性关节炎的生理学 抽象的 开发新的成像技术来识别和验证炎症性关节炎疾病的生物标志物 引起了广泛的兴趣，并与医生、医学研究人员和科学实体的共同目标保持一致。 在地下组织中呈现高度敏感的光学信息，其空间分辨率可与 超声（US）成像，新兴的光声（PA）成像为早期成像提供了显着的优势。 通过提供额外的新功能来诊断和预后，以及评估关节炎的治疗 有关疾病活动的信息可以有效地与更成熟和更广泛的结合 接受肌肉骨骼超声成像。我们目前对关节炎患者的研究已成功证明 联合 US-PA 系统能够识别和表征人类外周炎症 关节，基于血流动力学和代谢变化的检测，包括充血和缺氧。 这些是滑膜炎重要的早期生理生物标志物，反映了代谢需求的增加 以及炎症滑膜组织的氧气输送相对不足。 受到我们对关节炎患者的研究初步成功的鼓舞，我们建议进一步推进 US-PA 双成像技术转化为炎症性关节炎的临床治疗。我们的最终目标 是开发一种具有成本效益的床旁联合成像设备，可以实现早期治疗修改 个性化医疗，改变了风湿病临床的现行程序。在本研究中，为了 了解所提出的成像技术的临床价值后，我们将确定一组稳健、可靠的 可重复、精确的生物标志物，可以反映炎症性关节炎的早期病理变化 及其对治疗的反应。中心假设是一组 3D US 和 PA 生物标记物可以 通过所提出的成像技术进行评估可以更好地评估关节炎疾病状态和 治疗反应优于传统 2D US 成像评估的治疗反应。为了检验这个假设， 将实现以下具体目标： 目标 1：开发一种通过量化 3D US 和 PA 来评估炎症性关节炎疾病活动性的方法 反映特定关节潜在病理状况的生物标志物 目标 2：评估这些生物标志物在评估局部关节病理状况方面的表现 通过对完善的动物模型的研究发现关节炎的影响 目标 3. 评估 US-PA 可以评估的已识别成像生物标志物的临床价值 通过对炎症性关节炎患者进行试点研究的双模态技术