Children's Exposure to Metals, MicroRNAs and Biomarkers of Renal Health
儿童接触金属、MicroRNA 和肾脏健康生物标志物的情况
基本信息
- 批准号:9386450
- 负责人:
- 金额:$ 10.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-15 至 2018-08-31
- 项目状态:已结题
- 来源:
- 关键词:7 year oldAddressAdultAgeArchivesBiogenesisBioinformaticsBiological MarkersBiometryBiostatistical MethodsBirthBloodBlood PressureCadmiumCardiovascular systemChildChild health careChildhoodChronic Kidney FailureCitiesClinicalCreatinineDataDetectionDevelopmentDistalDoseDuct (organ) structureElderlyElectrolytesEnvironmentEnvironmental HealthEnvironmental Risk FactorEpidemiologyEpigenetic ProcessExposure toFailure to ThriveFiltrationFunctional disorderFutureGene ExpressionGoalsGrowthHairHealthHeavy MetalsHypertensionIndividualInternationalKidneyKidney DiseasesKidney GlomerulusLeadLifeMeasurableMeasuresMediatingMediationMediator of activation proteinMentorsMentorshipMercuryMetal exposureMetalsMexicoMicroRNAsNail plateNational Institute of Diabetes and Digestive and Kidney DiseasesNephrologyNephronsNephrotic SyndromeObesityOsmolalitiesOutcomeParentsPediatricsPerinatalPhenotypePhysiologyPlasmaPositioning AttributePredispositionPregnancyProteinsRenal functionResearchResearch ActivityResearch PersonnelResearch Project GrantsRiskRisk FactorsRoleSamplingScienceScientistSignal TransductionSiteStatistical MethodsSystemTestingToxic effectToxicologyTrainingTraining ActivityTranscriptTranslationsTubular formationUntranslated RNAUrineVisitWorkcohortcostearly childhoodearly life exposurefetalhigh riskimprovedindexinginfancyinnovationlead exposuremicroRNA biomarkersnephrotoxicitynovelpre-clinicalprenatalpreventprogramsprotein profilingskillssocial stresstherapy designtooltoxic metaltoxicanturinary
项目摘要
PROJECT SUMMARY
Toxic metals including cadmium (Cd), mercury (Hg), and lead (Pb) are known renal toxicants in adults;
however, their renal toxicity in developing children is understudied. Prenatal and early childhood are potential
susceptibility windows for renal toxic metals as these life stages are associated with development and
differentiation of renal filtration, secretion, and reabsorptive systems. The aim of this study is to determine
whether exposure to heavy metals early in life contributes to renal toxicity in children and whether miRNAs
mediate metal nephrotoxicity. To accomplish our goals, we will leverage an established longitudinal birth cohort
in Mexico City - the Programming Research in Obesity, GRowth Environment and Social Stress (PROGRESS)
study, which has measured levels of renal toxic metals (Cd, Hg, Pb) longitudinally in blood, hair, and nails as
well as blood pressure, and collected urine at each visit. In addition to childhood blood pressure, the proposed
research will examine preclinical indicators of renal dysfunction in three discrete regions of the kidney: the
glomerulus, proximal tubule and distal nephron (i.e. distal tubule and collecting duct). Dr. Sanders will receive
training in renal developmental physiology, as well as advanced biostatistical methods to address innovative
hypotheses regarding the origins of toxic renal programming in children, an understudied aspect of
environmental health. The mentoring team includes internationally recognized scientists with specializations in
nephrology, biostatistics, metals toxicology, epidemiology, and epigenetics, including Dr. Lisa Satlin, Dr. Chris
Gennings, Dr. Robert Wright, Dr. Andrea Baccarelli, and Dr. Stephanie Engel. This K99/R00 proposal
leverages Dr. Sanders' previous training in exposure science, epidemiology, and epigenetics with new
specialization in renal physiology and biostatistics; Dr. Sanders will also benefit from supplemental toxicology
and clinical training. The following aims will be accomplished: 1) Determine whether prenatal/early life metal
exposure predicts childhood blood pressure or functional biomarkers in specific kidney regions. 2) Apply a
novel biostatistical approach to enable “detection” of metal-associated renal toxicity that is global or site-
specific. 3) Examine the role of urinary miRNAs as biomarkers/mediators of metal-renal health relationships.
These findings will advance the field of children's renal health as well as generate new hypotheses about
metals and specific mechanisms that may contribute to the pathophysiology of adverse renal outcomes. The
proposed training and research activities will provide Dr. Sanders with the skills to become an independent
investigator studying early life metal exposure and renal development in future epidemiologic or toxicologic
research activities.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Alison P Sanders其他文献
Alison P Sanders的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Alison P Sanders', 18)}}的其他基金
Metal mixture effects on mitochondrial dysfunction in kidney development and maturation: Towards a whole mixture risk assessment
金属混合物对肾脏发育和成熟过程中线粒体功能障碍的影响:进行整体混合物风险评估
- 批准号:
10558509 - 财政年份:2023
- 资助金额:
$ 10.41万 - 项目类别:
Children's Exposure to Metals, MicroRNAs and Biomarkers of Renal Health
儿童接触金属、MicroRNA 和肾脏健康生物标志物的情况
- 批准号:
10500854 - 财政年份:2021
- 资助金额:
$ 10.41万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 10.41万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 10.41万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 10.41万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 10.41万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 10.41万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 10.41万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 10.41万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 10.41万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 10.41万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 10.41万 - 项目类别:
Research Grant