Biostatistics

项目摘要/摘要：生物统计学共享资源（BSR） 生物统计共享资源（BSR）的目标是确保为以下方面提供出色和及时的生物统计支持： 研究设计和开发、数据管理、数据分析和解释， 亚利桑那大学癌症中心（UACC）的所有研究项目的方式。BSR还提供 根据需要，采用创新的统计设计方法，以确保UACC调查人员实现其科学目标。 目标.这种支持通过团队方法和特定BSR的长期专门参与来促进 所有四个UACC研究项目中的人员。BSR的教职员工通力合作， 参与概念、设计、实施、分析和报告/手稿准备 UACC内进行的实验室、转化、临床和基于人群的研究。所述BSR 提供以下服务：1）针对个人科学目标和专业知识的广泛咨询 （有经验与早期研究者;临床与基础研究背景）; 2）统计学考虑 （将科学目标转化为统计上可检验的假设，样本大小/ 把握度论证和统计分析计划的制定）; 3）统计分析和展示 (from从短期统计咨询到长期合作参与正在进行的研究 项目）; 4）监测正在进行的研究进展（应计报告、数据完整性和结果 确定）; 5）数据管理（使用OnCore和REDCap）; 6）临床方案开发（样本 规模论证和制定适当的统计分析方法）; 7）协助编制 8）《科学评论》服务部门对UACC协议的统计审查 委员会; 9）通过数据和安全性监测服务监测研究安全性和数据完整性 10）教育和培训（包括临床研究员研讨会和 UACC研究计划）。BSR成员在设计和分析方面发挥着重要作用， 调查人员为他们的研究问题制定一个逻辑框架，并帮助确保有效的解释 的结果。

Project Summary / Abstract: Biostatistics Shared Resource (BSR) The goal of the Biostatistics Shared Resource (BSR) is to ensure excellent and timely biostatistical support for study design and development, data management, and data analysis and interpretation in a cost-effective manner for all Research Programs of the University of Arizona Cancer Center (UACC). BSR also provides innovative approaches to statistical design, as needed, to ensure UACC investigators achieve their scientific goals. This support is facilitated by a team approach and the long-term dedicated involvement of specific BSR personnel embedded within all four of the UACC Research Programs. BSR faculty and staff are collaboratively involved in the conception, design, implementation, analysis, and reporting/manuscript preparation of laboratory, translational, clinical, and population-based research conducted within the UACC. The BSR provides the following services: 1) extensive consultation tailored to individual scientific goals and expertise (experienced vs. early stage investigator; clinical vs. basic research background); 2) statistical considerations for funding applications (translation of scientific objectives into statistically testable hypotheses, sample size / power justifications, and development of statistical analysis plans); 3) statistical analysis and presentation (from short-term statistical consultations to longer-term collaborative involvement in ongoing research projects); 4) monitoring ongoing study progress (accrual reporting, data completeness, and outcome ascertainment); 5) data management (use of OnCore and REDCap); 6) clinical protocol development (sample size justification and development of an appropriate statistical analysis approach); 7) assistance in preparation of manuscripts and reports; 8) statistical review of UACC protocols by service on the Scientific Review Committee; 9) monitoring study safety and data integrity through service on the Data and Safety Monitoring Board; 10) education and training (including presentations in workshops for clinical fellows and seminars for UACC Research Programs). BSR members play an essential role in design and analysis and also work with investigators to develop a logical framework for their research questions and help to ensure valid interpretation of the results.