CORE--BIOMETRY

生物测量核心的目标是为所有项目提供数据管理和计算支持，并与项目调查人员合作开发和应用设计和分析的统计方法。这一目标是通过以下具体目标实现的：1.提供所有临床和实验室研究的统计设计和审查，包括可行性评估和样本量估计。2.制定收集数据的程序，提供数据输入，并维持计算机数据库，以便储存和检索信息。3.在所有方案项目研究的执行和分析方面提供统计合作。4.解释与所有项目相关的统计和生物学文献，并开发新的研究设计和数据分析程序，以满足计划项目目标。计划项目研究的所有阶段都需要生物测量学支持。在研究设计期间，核心处理功率和样本大小，并与研究调查人员合作建立数据管理程序。该中心提供关于研究进展的业务报告，并为内部和外部数据监测委员会会议编写总结材料。该核心与研究调查人员合作进行统计分析。核心人员还准备并协助准备出版手稿。所有项目研究人员在临床和实验室研究中继续使用生物测量学核心。

The goal of the Biometry Core is to provide data management and computing support for all projects, and to collaborate with project investigators in the development and application of statistical methods for design and analysis. This goal is achieved through the following specific aims: 1. To provide statistical design and review of all clinical and laboratory studies including feasibility assessment and sample size estimation. 2. To develop procedures for data collection, to provide data entry, and to maintain computer databases for information storage and retrieval. 3. To provide statistical collaboration in the execution and analysis of all program project studies. 4. To interpret the statistical and biological literature relevant to all projects, and to develop new study design and data analysis procedures to meet program project objectives. Biometry support is required in all phases of program project studies. During study design the core addresses power and sample sizes, and works with study investigators to establish data management procedures. The core provides operational reports on study progress, and prepares summary materials for Internal and External Data Monitoring Committee meetings. The core performs statistical analyses in collaboration with study investigators. Core personnel also prepare and assist in the preparation of manuscripts for publication. The Biometry Core continues to be used by all program investigators in clinical and laboratory studies.