Increasing AIAN Research Engagement through a Culturally Adapted Ethics Training

描述（由申请人提供）：美国印第安人和阿拉斯加原住民（AIAN）面临着明显的健康差距，而AIAN特定的研究在解决AIAN健康问题方面落后于其他种族和民族数据。让AIAN社区成员参与研究过程可以减少研究的不信任，提高科学的严谨性，并使更多的AIAN作为参与者和潜在的未来学者参与研究。然而，社区参与研究（CEnR）的一个重要障碍是缺乏对社区合作伙伴的文化相关的人类受试者的研究伦理教育。这一早期研究者发起的提案（PA-13 - 302）解决了迫切需要增加AIAN参与在印第安人地区进行的联邦资助研究的设计，实施和传播的问题，并影响到他们社区的健康和福利。通过这样做，这项研究解决了美国国立卫生研究院（NIH）的主要目标“加强我们国家的研究能力，扩大我们的研究基础，激发当代和后代研究人员对科学的热情。"总体目标是加强研究能力，增加AIAN社区参与NIH资助的研究，方法是为IRB合作培训倡议（CITI）创建一个文化相关的培训模块，该模块适用于AIAN，可访问和可通过，同时提高其教育价值。之所以选择"研究学生"模块进行调整，是因为它全面涵盖了对人类主体的各种保护和语言水平。使用CEnR方法，这项创新研究将通过创建文化上适当的培训，将贝尔蒙特原则应用于基本的人类受试者保护，从而增加AIAN社区对研究的知情参与。目标1旨在确定语言，并在目前的CITI "学生在研究"培训模块，需要文化适应AIAN社区研究人员的研究实例。目标1将通过一个迭代过程来实现，该过程借鉴了由具有AIAN研究专长的AIAN社区领导人、研究人员和伦理学家组成的国家专家小组的专门知识。目标2旨在开发和心理测试验证一个文化适应和AIAIN人口访问版本的模块，旨在通过增加研究伦理知识，研究效率和研究信任，增加AIAIN社区成员参与研究。目标2将通过初步的β测试和随后在AIAN潜在研究伙伴的全国代表性样本中进行的大规模双臂随机对照试验来实现。该项目的目标3是将研究结果转化为政策和实践指南。AI 3将通过CITI、美洲印第安人全国大会和美洲印第安人高等教育联合会传播培训供立即使用来实现。该提案的重要性在于有可能推进印度全国NIH资助研究的伦理培训科学。它旨在发展研究能力，为生活在美国各地的AIAN服务，一个有可能扩大健康差距的群体。

DESCRIPTION (provided by applicant): American Indian and Alaska Natives (AIAN) face glaring health disparities, and AIAN-specific research lags behind other racial and ethnic data in addressing AIAN health concerns. Engaging AIAN community members in the research process can reduce research mistrust, increase scientific rigor, and expose more AIAN to research both as participants and potentially as future scholars. A significant barrier to community engaged research (CEnR), however, is the absence of culturally relevant human subject's research ethics education for community partners. This early stage investigator initiated (PA-13-302) proposal addresses the urgent need to increase participation of AIAN in the design, implementation and dissemination of federally funded research conducted in Indian Country and affecting the health and welfare of their communities. By doing so, this study addresses a primary goal of the National Institutes of Health (NIH) "to strengthen our nation's research capacity, broaden our research base, and inspire a passion for science in current and future generations of researchers." The overarching goal is to strengthen research capacity and increase AIAN community involvement in NIH-funded research by creating a culturally relevant training module for the Collaborative IRB Training Initiative (CITI) that is applicable, accessible and passable for AIAN while enhancing its educational value. The "student in research" module was selected for adaptation because of its comprehensive coverage of a full range of human subject's protections and language level. Using a CEnR approach, this innovative study will increase informed AIAN community involvement in research by creating culturally appropriate training that applies Belmont principles to fundamental human subjects protections. Aim 1 seeks to identify language, and research examples in the current CITI "student in research" training module that requires cultural adaptation for AIAN community researchers. Aim 1 will be achieved through an iterative process that draws on the expertise from a national expert panel of AIAN community leaders, researchers and ethicists with expertise in AIAN research. Aim 2 seeks to develop and psychometrically validate a culturally adapted and AIAIN population accessible version of the module designed to increase AIAN community members' involvement in research through increased research ethics knowledge, research efficacy, and research trust. Aim 2 will be achieved through preliminary beta testing and a subsequent large-scale two-arm randomized controlled trial among a nationally representative sample of AIAN potential research partners. Aim 3 of the project is to translate the findings into policy and practice guidelines. Ai 3 will be achieved by disseminating the training for immediate use through the CITI, National Congress of American Indians, and American Indian Higher Education Consortium. The significance of this proposal lies in the potential to advance science in ethics training for NIH-funded research across Indian Country. It is geared toward developing research capacity serving AIAN living across the U.S., a group at risk for expanding health disparities.