Administrative Core
行政核心
基本信息
- 批准号:9312410
- 负责人:
- 金额:$ 6.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-04-07 至 2022-03-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAdherenceAdministratorAdvisory CommitteesAwardBiologyBiomedical EngineeringBostonClinicalClostridium difficileCollaborationsCommunicable DiseasesCommunicationCommunitiesCryptosporidiumDataDevelopmentDiseaseDisease modelDoctor of PhilosophyEnsureEnteralEvaluationFundingGoalsGuidelinesHuman ResourcesIn VitroIndividualInstitutesIntellectual PropertyIntestinesLaboratoriesLightMentorsModelingNational Institute of Allergy and Infectious DiseaseOrganismPathogenesisPerformancePilot ProjectsProceduresPropertyRecruitment ActivityResearchResearch PersonnelResearch Project GrantsResourcesRoleSamplingScientistSourceSpecialistStudentsSystemTechnologyTechnology TransferTimeTissue EngineeringTissue ModelTissuesTrainingU-Series Cooperative AgreementsUniversitiesVibrio choleraeYersinia enterocoliticaclinical materialgastrointestinal functionhuman tissueinfectious disease modelinsightmeetingsmembernature centernoveloperationoutreachpathogenprogramsresearch and developmentsymposiumsynergism
项目摘要
The Administrative Core of the Center for Enteric Diseases in Engineered Tissue (CEDET) will oversee the
day-to-day operations of the Center, ensuring that the scientific Aims of the Center are met. The Core
Director, Dr. Ralph Isberg, will oversee the Core in collaboration with the Associate Director, Dr. David Kaplan
along with two part-time administrators. Members of the Internal Scientific Advisory Committee, consisting of
the Director, Associate Director and two additional Investigators, will perform various administrative duties.
The primary duties of the Administrative Core will include the tracking of key Milestones, which are research
accomplishments expected to be completed at various time points during the support of the Center. The Core
is responsible for ensuring scientific synergy among the three proposed Projects, facilitating transfer of
technology between workers on the various Projects. In addition, a Mentoring Plan will be instituted to allow
collaborative guidance of students and fellows who will be working on the three Projects. Guidance regarding
the conduct of the Center will be obtained from members of an External Scientific Advisory committee. The
external members will be distinguished scientists in the fields of tissue engineering, enteric disease biology,
and gastrointestinal function. The most important role of the External Scientific Advisory Committee will be to
evaluate progress in achieving milestones and to suggest alternate strategies, when needed. A key
responsibility of the Core will be to establish procedures for submission, evaluation and awarding of Pilot
Development Research Projects, which are intended to encourage the use of alternate strategies, new tissue
sources, as well as allow the interrogation of enteropathogens not covered in the Center. The Core will also
organize a yearly University-wide Symposium that will allow Center members to interface with the greater
Boston community, promoting interaction between Center scientists and other researchers, as well as
facilitating interaction with invited speakers, who will be leaders in the fields of enteropathogenesis and tissue
engineering.
工程组织肠道疾病中心(CEDET)的行政核心将监督
中心的日常运作,确保中心的科学目标得以实现。核心
主任Ralph Isberg博士将与副主任大卫卡普兰博士合作监督核心
沿着的还有两名兼职管理员。内部科学咨询委员会成员,包括
主任、协理主任和另外两名调查员将履行各种行政职责。
行政核心的主要职责将包括跟踪关键里程碑,即研究
预期在支持中心期间的不同时间点完成的成就。核心
负责确保三个拟议项目之间的科学协同作用,
在不同的项目中,工人之间的技术。此外,还将制定指导计划,
学生和研究员谁将在三个项目工作的协作指导。指导意见
中心的行为将从外部科学咨询委员会的成员那里获得。的
外部成员将是组织工程,肠道疾病生物学,
和胃肠道功能。外部科学咨询委员会最重要的作用是
评估实现里程碑的进展情况,并在需要时提出替代策略。一个关键
核心委员会的职责是建立试点项目的提交、评估和授予程序
发展研究项目,旨在鼓励使用替代战略,新组织
来源,以及允许在该中心没有涵盖的肠道病原体的审讯。核心也将
组织每年一次的大学范围的研讨会,使中心成员能够与更大的
波士顿社区,促进中心科学家和其他研究人员之间的互动,以及
促进与受邀演讲者的互动,他们将是肠道发病机制和组织领域的领导者
工程.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ralph R. Isberg其他文献
Identification of determinants that allow maintenance of high-level fluoroquinolone resistance in emAcinetobacter baumannii/em
鉴定可维持鲍曼不动杆菌高水平氟喹诺酮类耐药性的决定因素
- DOI:
10.1128/mbio.03221-24 - 发表时间:
2024-11-29 - 期刊:
- 影响因子:4.700
- 作者:
Efrat Hamami;Wenwen Huo;Juan Hernandez-Bird;Arnold Castaneda;Jinna Bai;Sapna Syal;Juan C. Ortiz-Marquez;Tim van Opijnen;Edward Geisinger;Ralph R. Isberg - 通讯作者:
Ralph R. Isberg
emStreptococcus pneumoniae/em favors tolerance via metabolic adaptation over resistance to circumvent fluoroquinolones
肺炎链球菌通过代谢适应而非对氟喹诺酮类药物的耐药性来偏好耐受性
- DOI:
10.1128/mbio.02828-23 - 发表时间:
2024-01-23 - 期刊:
- 影响因子:4.700
- 作者:
Tina H. Dao;Haley Echlin;Abigail McKnight;Enolia S. Marr;Julia Junker;Qidong Jia;Randall Hayden;Tim van Opijnen;Ralph R. Isberg;Vaughn S. Cooper;Jason W. Rosch - 通讯作者:
Jason W. Rosch
Genetic evidence for a regulated cysteine protease catalytic triad in LegA7, a emLegionella pneumophila/em protein that impinges on a stress response pathway
军团菌肺炎蛋白 LegA7 中受调节的半胱氨酸蛋白酶催化三联体的遗传证据,该蛋白影响应激反应途径
- DOI:
10.1128/msphere.00222-24 - 发表时间:
2024-08-19 - 期刊:
- 影响因子:3.100
- 作者:
Dar Hershkovitz;Emy J. Chen;Alexander W. Ensminger;Aisling S. Dugan;Kaleigh T. Conway;Alex C. Joyce;Gil Segal;Ralph R. Isberg - 通讯作者:
Ralph R. Isberg
Sde proteins coordinate ubiquitin utilization and phosphoribosylation to establish and maintain the Legionella replication vacuole
Sde 蛋白协调泛素利用和磷酸核糖基化,以建立和维持军团菌复制泡
- DOI:
10.1038/s41467-024-51272-2 - 发表时间:
2024-08-30 - 期刊:
- 影响因子:15.700
- 作者:
Kristin M. Kotewicz;Mengyun Zhang;Seongok Kim;Meghan S. Martin;Atish Roy Chowdhury;Albert Tai;Rebecca A. Scheck;Ralph R. Isberg - 通讯作者:
Ralph R. Isberg
Le mécanisme moléculaire de l'invasion cellulaire par Yersinia pseudotuberculosis par interaction de l'invasine et de l'intégrine
假结核耶尔森菌细胞侵袭分子机制与侵袭与整合相互作用
- DOI:
10.1016/s0924-4204(97)84731-2 - 发表时间:
1997 - 期刊:
- 影响因子:0
- 作者:
P. Dersch;Ralph R. Isberg - 通讯作者:
Ralph R. Isberg
Ralph R. Isberg的其他文献
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{{ truncateString('Ralph R. Isberg', 18)}}的其他基金
The interface between L. pneumophila manipulation of host endoplasmic reticulum and innate immune subterfuge
嗜肺军团菌操纵宿主内质网与先天免疫诡计之间的界面
- 批准号:
10331320 - 财政年份:2020
- 资助金额:
$ 6.58万 - 项目类别:
Molecular basis of metal acquisition by an intravacuolar pathogen
液泡内病原体获取金属的分子基础
- 批准号:
10259847 - 财政年份:2020
- 资助金额:
$ 6.58万 - 项目类别:
Molecular basis of metal acquisition by an intravacuolar pathogen
液泡内病原体获取金属的分子基础
- 批准号:
10033724 - 财政年份:2020
- 资助金额:
$ 6.58万 - 项目类别:
Molecular basis of metal acquisition by an intravacuolar pathogen
液泡内病原体获取金属的分子基础
- 批准号:
10444928 - 财政年份:2020
- 资助金额:
$ 6.58万 - 项目类别:
Molecular basis of metal acquisition by an intravacuolar pathogen
液泡内病原体获取金属的分子基础
- 批准号:
10646234 - 财政年份:2020
- 资助金额:
$ 6.58万 - 项目类别:
The interface between L. pneumophila manipulation of host endoplasmic reticulum and innate immune subterfuge
嗜肺军团菌操纵宿主内质网与先天免疫诡计之间的界面
- 批准号:
10554261 - 财政年份:2020
- 资助金额:
$ 6.58万 - 项目类别:
Engineering of Complex Infectious Loci in Culture
培养中复杂感染位点的工程
- 批准号:
10092952 - 财政年份:2020
- 资助金额:
$ 6.58万 - 项目类别:
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