Direct Evaluation of Muscle Strength and Motor Control Properties in Aging

衰老过程中肌肉力量和运动控制特性的直接评估

• 批准号: 9188459
• 负责人: Shanette A Go
• 金额: $ 4.9万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-12-01 至 2019-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9188459
• 关键词: Address; Adult; Affect; Age; Aging; Aging-Related Process; Animals; Assessment tool; Behavior; Biomechanics; Clinic; Clinical; Clinical assessments; Complement; Coupling; Data; Deterioration; Development; Diagnosis; Diagnostic; Disease; Disease Progression; Doctor of Philosophy; Elderly; Environment; Equilibrium; Evaluation; Fall injury; Fatigue; Gait speed; Generations; Goals; Grant; Health; Incidence; Individual; Injury; Intramuscular; Joints; Knowledge; Laboratories; Length; Life; Literature; Measurement; Measures; Mechanics; Mentors; Methodology; Methods; Monitor; Motor; Motor Neurons; Muscle; Muscle Fibers; Muscle Weakness; Muscle function; Muscular Atrophy; Musculoskeletal; Orthopedics; Outcome; Output; Pathology; Performance; Physical Function; Physicians; Physiology; Plant Roots; Population; Prevalence; Property; Public Health; Recruitment Activity; Research; Research Training; Resistance; Risk; Scientist; Signal Transduction; Skeletal Muscle; Techniques; Technology; Testing; Therapeutic; Torque; Training; Translating; Treatment Efficacy; Work; age effect; age related; aging population; base; career; clinical decision-making; disability; experience; falls; functional decline; improved; improved functioning; improved outcome; innovation; minimally invasive; motor control; multidisciplinary; muscle form; muscle strength; novel; novel strategies; pressure; prevent; programs; public health relevance; response; sarcopenia; skill acquisition; tool; young adult

 DESCRIPTION (provided by applicant); Sarcopenia, defined as loss of muscle mass and strength, affects as much as 70% of adults over the age of 60 years and is associated with significant functional decline, increased risk for injury, and decreased independence. Present literature suggests preferential loss of muscle fibers capable of generating high forces. We believe that motor control mechanisms are altered in older individuals, affecting their force generating ability. Motor control properties may be assessed through analysis of electromyographic signals. However, present clinical assessments for weakness can only measure the total torque generated about a joint by groups of muscles, and cannot provide valuable information regarding the torque exerted by a single muscle. Therefore, a critical need exists to develop tools that can measure the tension generated by individual muscles and accurately assess changes in strength and neuromotor drive. Intramuscular pressure (IMP) is the pressure produced within skeletal muscle as it changes length, and is a promising approach to gauge skeletal muscle function. Our long-term goal is to develop a minimally invasive clinical tool that can improve diagnostic and therapeutic strategies to improve the functioning of older individuals affected by weakness. This application's objectives are to develop and validate a minimally invasive method to assess neuromotor drive and force generation of individual muscles. Our central hypothesis is that simultaneous EMG and IMP measurements can be used to evaluate muscle electromechanical performance. To test this hypothesis, we will pursue two specific aims: AIM 1: Validate novel analyses of EMG and IMP measurements to evaluate electromechanical coupling in young adults. AIM 2: Evaluate sarcopenia-related changes in electromechanical coupling in older adults. The expected outcome of the proposed work is the development of an innovative methodology to evaluate the effect of aging and sarcopenia on the electromechanical performance of individual muscles. This work will be significant since it is the first step towards developing more effective tools for the assessment of muscle weakness, which, in turn, will improve diagnosis, monitoring of disease progression, and therapeutic strategies for elderly individuals struggling with the effects of sarcopenia.

 描述（由申请人提供）;肌肉减少症，定义为肌肉质量和力量的损失，影响多达70%的60岁以上的成年人，并与显著的功能下降、受伤风险增加和独立性降低相关。目前的文献表明，优先损失的肌肉纤维能够产生高的力量。我们认为，老年人的运动控制机制发生了改变，影响了他们的力量产生能力。运动控制特性可以通过分析肌电信号来评估。然而，目前对无力的临床评估只能测量由肌肉组围绕关节产生的总扭矩，并且不能提供关于由单个肌肉施加的扭矩的有价值的信息。因此，迫切需要开发能够测量个体肌肉产生的张力并准确评估力量和神经运动驱动的变化的工具。肌内压（IMP）是骨骼肌长度变化时产生的压力，是一种很有前途的测量骨骼肌功能的方法。我们的长期目标是开发一种微创临床工具，可以改善诊断和治疗策略，以改善受虚弱影响的老年人的功能。该应用程序的目标是开发和验证一种微创方法，以评估神经运动驱动和个体肌肉的力量生成。我们的中心假设是，同时EMG和IMP测量可用于评估肌肉机电性能。为了验证这一假设，我们将追求两个具体的目标：目的1：EMG和IMP测量的新颖分析，以评估年轻人的机电耦合。目的2：评估老年人肌减少症相关的机电耦合变化。拟议的工作的预期成果是开发一种创新的方法，以评估个人肌肉的机电性能的老化和肌肉减少症的影响。这项工作将是重要的，因为它是朝着开发更有效的评估肌肉无力的工具迈出的第一步，这反过来将改善诊断，监测疾病进展，以及为老年人与肌肉减少症的影响作斗争的治疗策略。