Neural Network Biomarkers for Relational Memory and Psychosis in Schizophrenia

精神分裂症关系记忆和精神病的神经网络生物标志物

基本信息

  • 批准号:
    9312869
  • 负责人:
  • 金额:
    $ 16.97万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-08-01 至 2019-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The neurobiological mechanisms of schizophrenia (SZ) remain unknown, hindering the development of effective treatments. The identification of pathogenetically-relevant disease biomarkers and their subsequent testing as measures for treatment response are critical for the field. This research proposal aims to test anatomical and functional biomarkers for declarative (i.e., relational) memory dysfunction and their associations with psychosis in patients with SZ, with an emphasis on system-level alterations within the hippocampus-neocortical (Hipp-NC) brain network. We will carry out this examination at two levels: (1) within Hipp circuitry, to test Hipp subfield contributions to relational memory (RM) dysfunction and psychosis, using high resolution functional MRI (fMRI), and (2) within the Hipp-NC network, to test system-level biomarkers, using standard resolution fMRI, and connectivity analyses (resting state fMRI, DTI). Ultimately, our goal is to define Hipp-NC-mediated systems-level 'biosignatures' for RM dysfunction and psychosis in SZ by testing inter-relations between the regional outcomes within and across Hipp circuitry and Hipp-NC networks and their association with RM behavioral and psychosis manifestation outcomes. We will conduct these experiments in 30 outpatients with SZ or schizoaffective disorder, contrasted with 30 healthy individuals. It is the testing of system-level disease biomarkers using cutting-edge high- and standard-resolution multimodal brain imaging methodology that make this proposal highly innovative. The outcomes of this research may generate novel Hipp-NC-bound biomarkers for SZ, contribute to understanding the role of Hipp-NC system in pathogenesis of cognitive dysfunction and psychosis, and aid in the future development of objective measures for treatment response in SZ and related psychotic disorders. Pursuit of the proposed studies will not only advance knowledge in this research field, but also provide a valuable framework for achieving the broader aims of the candidate's training and career development program. The candidate's immediate goal is to develop a career as an independent investigator in the field of translational neuroscience research in SZ. To achieve this goal, the candidate has organized a training program involving coursework, readings, workshops, conferences, and consultations with the mentor and the team of consultants (all actively collaborating with the mentor) who are leading experts in neuroimaging and cognitive neuroscience research in SZ, as well as system-level analytic approaches. Research and training activities will be carried out at UT Southwestern Medical Center, the Division of Translational Neuroscience Research in Schizophrenia and the Advanced Imaging Research Center that will provide an infrastructure for the candidate's proposed research and training plan. This career development Award will enable the candidate's overall goals of contributing to the understanding of neurobiology of psychosis and informing new treatment development efforts.
描述(由申请人提供):精神分裂症(SZ)的神经生物学机制仍然未知,阻碍了有效治疗的开发。鉴定与致病相关的疾病生物标志物及其随后的测试作为治疗反应的测量对于该领域至关重要。本研究计划旨在测试 SZ 患者陈述性(即关系性)记忆功能障碍的解剖学和功能性生物标志物及其与精神病的关系,重点是海马-新皮质 (Hipp-NC) 大脑网络内的系统级改变。我们将在两个层面上进行这项检查:(1) 在 Hipp 电路内,使用高分辨率功能 MRI (fMRI) 测试 Hipp 子域对关系记忆 (RM) 功能障碍和精神病的影响;(2) 在 Hipp-NC 网络内,使用标准分辨率 fMRI 和连接分析(静息态 fMRI、DTI)测试系统级生物标志物。最终,我们的目标是通过测试 Hipp 电路和 Hipp-NC 网络内部和之间的区域结果之间的相互关系及其与 RM 行为和精神病表现结果的关联,定义 SZ 中 RM 功能障碍和精神病的 Hipp-NC 介导的系统级“生物特征”。我们将在 30 名患有精神分裂症或分裂情感障碍的门诊患者中进行这些实验,并与 30 名健康个体进行对比。正是使用尖端的高分辨率和标准分辨率多模态脑成像方法来测试系统级疾病生物标志物,使得该提案具有高度创新性。这项研究的结果可能会产生新的 Hipp-NC 结合的 SZ 生物标志物,有助于了解 Hipp-NC 系统在认知功能障碍和精神病发病机制中的作用,并有助于未来开发针对 SZ 和相关精神障碍治疗反应的客观措施。进行拟议的研究不仅可以增进该研究领域的知识,而且还可以为实现候选人培训和职业发展计划的更广泛目标提供有价值的框架。该候选人的近期目标是在深圳的转化神经科学研究领域发展成为一名独立研究员的职业生涯。为了实现这一目标,候选人组织了一个培训计划,包括课程作业、阅读、研讨会、会议以及与导师和顾问团队(都与导师积极合作)的咨询,他们是深圳神经影像和认知神经科学研究以及系统级分析方法的领先专家。研究和培训活动将在德克萨斯大学西南医学中心、精神分裂症转化神经科学研究部和高级影像研究中心进行,该中心将为候选人提出的研究和培训计划提供基础设施。该职业发展奖将使候选人实现促进对精神病神经生物学的理解并为新的治疗开发工作提供信息的总体目标。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Elena Ivanovna Ivleva其他文献

Elena Ivanovna Ivleva的其他文献

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{{ truncateString('Elena Ivanovna Ivleva', 18)}}的其他基金

Aging and Disease Course: Contributions to Lifespan Neurobiology of Schizophrenia
衰老和疾病过程:对精神分裂症寿命神经生物学的贡献
  • 批准号:
    10438920
  • 财政年份:
    2021
  • 资助金额:
    $ 16.97万
  • 项目类别:
Aging and Disease Course: Contributions to Lifespan Neurobiology of Schizophrenia
衰老和疾病过程:对精神分裂症寿命神经生物学的贡献
  • 批准号:
    10278892
  • 财政年份:
    2021
  • 资助金额:
    $ 16.97万
  • 项目类别:
Aging and Disease Course: Contributions to Lifespan Neurobiology of Schizophrenia
衰老和疾病过程:对精神分裂症寿命神经生物学的贡献
  • 批准号:
    10612427
  • 财政年份:
    2021
  • 资助金额:
    $ 16.97万
  • 项目类别:
Neural Network Biomarkers for Relational Memory and Psychosis in Schizophrenia
精神分裂症关系记忆和精神病的神经网络生物标志物
  • 批准号:
    8765520
  • 财政年份:
    2014
  • 资助金额:
    $ 16.97万
  • 项目类别:
Neural Network Biomarkers for Relational Memory and Psychosis in Schizophrenia
精神分裂症关系记忆和精神病的神经网络生物标志物
  • 批准号:
    8899641
  • 财政年份:
    2014
  • 资助金额:
    $ 16.97万
  • 项目类别:

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