Metabolism Core
新陈代谢核心
基本信息
- 批准号:8813136
- 负责人:
- 金额:$ 11.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-08-01 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerometerAcuteAddressAdolescentAdultAerobicAmericanAmino AcidsBiochemicalBiologicalBiometryBloodBody WaterCenters for Disease Control and Prevention (U.S.)Centers of Research ExcellenceChildCommunitiesControlled StudyData AnalysesDevelopmentDietary InterventionDoctor of PhilosophyEnergy MetabolismEquilibriumExerciseFacility ControlsFatty LiverFatty acid glycerol estersFundingFutureGoalsGrantHeart DiseasesHormonesHypertensionIndirect CalorimetryInformaticsInsulin ResistanceInterventionJointsLaboratoriesLipidsLiverLiver diseasesMeasurementMeasuresMentorsMetabolicMetabolismMethodologyNon-Insulin-Dependent Diabetes MellitusObesityPerformancePhysical activityPlasmaPopulationPregnant WomenPreventionProbioticsProceduresProteinsResearchResearch PersonnelRoleSamplingStructureSurveysTechniquesTestingTissue SampleTissuesTracerTrainingTranslational Researchdesignexercise physiologistexercise trainingexperiencefield studyfitnessflexibilityimprovedinsulin sensitivityintervention effectmetabolic abnormality assessmentmetabolic ratemuscle strengthnutritionobesity in childrenobesity preventionobesity treatmentoxidationpreventprotein degradationresponsestable isotopetherapy development
项目摘要
PROJECT SUMMARY
Through this COBRE application, we seek to establish the Center for Childhood Obesity Prevention. The goal
of the Metabolism Core C is to provide support for metabolic studies, including exercise studies and biological
sample analyses, for projects in the Center. It is recognized that suboptimal nutrition and exercise are
important factors in the development of obesity, and that improvement of these factors are vital for the reversal
of obesity and its corresponding disturbances in metabolism. The structure of this improvement is however
debated, e.g., can exercise alone, without changes in bodyweight, improve obesity related metabolic
disturbances. The Metabolism Core (MC) includes a physical activity facility for controlled studies of exercise
and substrate metabolism, a special procedure/testing facility, and an analytical lab for analyses of biological
samples. The MC will assist and mentor the junior investigators in the performance of metabolic studies,
including use of stable isotope tracer techniques to measure metabolic rates, and will assist in design of future
fundable studies of metabolism in obesity. Among the primary junior investigator projects, focus will be on the
response of lean and obese children and also obese pregnant women, to nutritional interventions (probiotics,
amino acids or protein). The effects of interventions on insulin sensitivity, fat oxidation, whole body protein
turnover (synthesis and breakdown), and plasma and liver lipid content/hepatic steatosis, will be determined.
The MC will also serve to educate and support the COBRE junior investigators in measurement of physical
activity and biological responses in community/field studies. Thus, the core adds to the uniqueness of the grant
in that lab studies and community studies of obesity are bridged in a translational manner. The Metabolism
Core is NEW to the revised application.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Elisabet Borsheim其他文献
Elisabet Borsheim的其他文献
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{{ truncateString('Elisabet Borsheim', 18)}}的其他基金
Center for Childhood Obesity Prevention - Metabolism and Bioenergetics Core
儿童肥胖预防中心 - 新陈代谢和生物能量学核心
- 批准号:
10270953 - 财政年份:2016
- 资助金额:
$ 11.21万 - 项目类别:
Center for Childhood Obesity Prevention - Metabolism and Bioenergetics Core
儿童肥胖预防中心 - 新陈代谢和生物能量学核心
- 批准号:
10474574 - 财政年份:2016
- 资助金额:
$ 11.21万 - 项目类别:
Center for Childhood Obesity Prevention - Metabolism and Bioenergetics Core
儿童肥胖预防中心 - 新陈代谢和生物能量学核心
- 批准号:
10689811 - 财政年份:2016
- 资助金额:
$ 11.21万 - 项目类别:
Effects of amino acids on regional lipid metabolism
氨基酸对局部脂质代谢的影响
- 批准号:
8602913 - 财政年份:2009
- 资助金额:
$ 11.21万 - 项目类别:
Effects of amino acids on regional lipid metabolism
氨基酸对局部脂质代谢的影响
- 批准号:
8318129 - 财政年份:2009
- 资助金额:
$ 11.21万 - 项目类别:
Effects of amino acids on regional lipid metabolism
氨基酸对局部脂质代谢的影响
- 批准号:
8129606 - 财政年份:2009
- 资助金额:
$ 11.21万 - 项目类别:
Effects of amino acids on regional lipid metabolism
氨基酸对局部脂质代谢的影响
- 批准号:
7751176 - 财政年份:2009
- 资助金额:
$ 11.21万 - 项目类别:
Effects of amino acids on regional lipid metabolism
氨基酸对局部脂质代谢的影响
- 批准号:
7924094 - 财政年份:2009
- 资助金额:
$ 11.21万 - 项目类别:
Effects of amino acids on regional lipid metabolism
氨基酸对局部脂质代谢的影响
- 批准号:
8529417 - 财政年份:2009
- 资助金额:
$ 11.21万 - 项目类别:
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