Center for Childhood Obesity Prevention - Metabolism and Bioenergetics Core

儿童肥胖预防中心 - 新陈代谢和生物能量学核心

基本信息

批准号：
10689811
负责人：
Elisabet Borsheim
金额：
$ 32.73万
依托单位：
ARKANSAS CHILDREN'S HOSPITAL RES INST
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10689811
关键词：
Adolescent Adult American Area Arkansas Bioenergetics Biological Biomedical Research Cell Energetics Cells Cellular Metabolic Process Child Clinical Chemistry Core Facility Data Analyses Development Doctor of Philosophy Education Energy Metabolism Exercise Physiology Extramural Activities Fatty acid glycerol esters Fee-for-Service Plans Fluorescence Funding Goals Grant Heart Diseases Human Hypertension Incidence Institution Insulin Resistance Knowledge Laboratories Leadership Longevity Mass Spectrum Analysis Mediating Mentors Mentorship Metabolic Metabolic dysfunction Metabolism Methodology Mission Mitochondria Monitor Non-Insulin-Dependent Diabetes Mellitus Obesity Organelles Phase Pilot Projects Play Population Pre-Clinical Model Prevention Research Prevention strategy Prevention therapy Research Research Assistant Research Design Research Institute Research Personnel Research Project Grants Research Support Resolution Respiratory physiology Role Sampling Services Spirometry Techniques Technology Tissues Training Translational Research Water base career data dissemination design fatty liver disease human model in vivo instrumentation investigator training novel novel strategies obesity in children obesity prevention oxidation preclinical study prevent programs protein degradation real time monitoring recruit skills stable isotope theories

项目摘要

PROJECT SUMMARY The Metabolism and Bioenergetics Core (MBC) is a critical research core in the Center for Childhood Obesity Prevention (CCOP). The MBC make cutting-edge biomedical research services available to CCOP investigators at Arkansas Children’s Research Institute (ACRI). Our specific expertise and focus are the application of stable isotope technologies and high resolution respirometry to the study of substrate metabolism and bioenergetics. The primary goal of the MBC is to support early stage CCOP investigators in research focused on the development, treatment, and prevention of obesity by providing access to instrumentation and expertise to execute studies focused on altered metabolism and bioenergetics. This encompasses study design, implementation, biological sample analyses, as well as data analyses and interpretation. The MBC will further mentor investigators in key methodological approaches used to quantify metabolism and bioenergetics. Our long-term goal is to transition the MBC into a sustainable core facility at ACRI with broad intra- and extra-institutional user base.

项目摘要代谢和生物能力核心（MBC）是儿童肥胖中心的关键研究核心预防（CCOP）。 MBC为CCOP提供了尖端的生物医学研究服务阿肯色州儿童研究所（ACRI）的研究人员。我们的具体专业知识和重点是稳定同位素技术和高分辨率呼吸测定法应用于底物的研究代谢和生物能学。 MBC的主要目标是支持早期CCOP调查人员研究的重点是通过提供进入肥胖的发展，治疗和预防仪器和专业知识，以执行研究的研究为改变代谢和生物能学。这包括研究设计，实施，生物样品分析以及数据分析和解释。 MBC将进一步指导研究人员，用于量化的关键方法论方法代谢和生物能学。我们的长期目标是将MBC转变为可持续的核心设施 ACRI具有广泛的内部和外部机构用户群。