SARRP 200 Platform for Image Guided Micro Irradiation

SARRP 200 图像引导微辐照平台

• 批准号: 9075077
• 负责人: Jacqueline Patricia Williams
• 金额: $ 60万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9075077
• 关键词: Address; Affect; Animal Model; Animals; Benign; Biological Models; Cancer Patient; Discipline; Disease; Elements; Equipment; Failure; Funding; Human; Image; Institution; Medical Oncologist; Medical Research; Medical center; Modality; Modeling; Mus; Normal tissue morphology; Operative Surgical Procedures; Patient-Focused Outcomes; Patients; Pre-Clinical Model; Protocols documentation; Radiation; Radiation Oncologist; Radiation therapy; Rattus; Request for Applications; Research; Research Personnel; Science; Techniques; Technology; Testing; Time; Translations; Tumor Tissue; Universities; chemotherapy; cone-beam computed tomography; experience; fly; image guided; innovation; instrument; irradiation; neoplastic cell; novel; pre-clinical; response; standard of care; tumor; unnecessary treatment

 DESCRIPTION (provided by applicant): Modern oncologic treatment usually involves a combination of treatments, including surgery, radiation therapy and/or chemotherapy. Incredible advances have been made in all of these disciplines over the past few decades, with, for example, radiation oncologists now being able to target and conform their beams in order to minimize unnecessary treatment of normal tissues and with the medical oncologists expanding their armamentarium to include biologics specifically targeted to tumor cells. Unfortunately, however, with only very few exceptions, the patient outcomes that have resulted from these advances have been incremental at best. Such disappointing results fly in the face of the significant benefits that many of these innovative treatments have demonstrated at the preclinical level. One explanation for this failure may be the translation of bench science to the bedside or vice versa, and is embodied in the standard practice employed by researchers when assessing a new strategy or agent: that is, each novel agent or technique, etc. is tested either in isolation or as a comparison against standard of care. Even when tested in combinations (i.e. with other agents), at no time is a novel agent assessed in conjunction with the likely additional modalities, surgery or irradiation. This is despite the fact that, for example, ~50% of patients wil experience fractionated radiation therapy during the course of their treatment, a therapy which is known to affect their tumor, its vasculature and the immediately surrounding normal tissues, all elements that may, in turn, affect the tumor's response to subsequent chemotherapy and/or biologics. In order to address this deficiency, our application requests funds to purchase a precision X- irradiator/cone beam CT for animal and cellular use at the University of Rochester Medical Center (URMC). The instrument, a small animal radiation research platform or SARRP, will address a critical need in medical research at the institution since it will allow investigatos to assess the synergy of agents with realistic radiation protocols in preclinical models, thereby trul modeling the human experience. Furthermore, the SARRP will be used in conjunction with other state-of-the-art imaging equipment, expanding researchers' abilities by allowing them to perform image-guided irradiation of small animal models (rats and mice). Overall, the addition of a SARRP to the technologies available at the University of Rochester will increase opportunities in both normal and tumor tissue research, providing investigators with more appropriate model systems for assessing tumor- normal tissue microenvironment, normal tissue effects seen in many cancer patients, and benign diseases.

 描述（由申请人提供）：现代肿瘤治疗通常涉及多种治疗的组合，包括手术、放射治疗和/或化疗。在过去的几十年里，所有这些学科都取得了令人难以置信的进步，例如，放射肿瘤学家现在能够瞄准并整合他们的光束，以最大限度地减少对正常组织的不必要治疗，并且医学肿瘤学家扩大了他们的医疗设备，包括专门针对肿瘤细胞的生物制剂。然而，不幸的是，除了极少数例外，这些进步所带来的患者结局充其量只是增量的。这些令人失望的结果与许多这些创新治疗在临床前水平上已经证明的显著益处背道而驰。这种失败的一种解释可能是将实验室科学转化为床边科学，反之亦然，并且体现在研究人员在评估新策略或药剂时采用的标准实践中：即，每种新药剂或技术等都在以下两种情况下进行测试： 隔离或作为与护理标准的比较。即使在联合试验（即与其他药物）时，也不能将新药物与可能的其他方式（手术或放疗）结合进行评估。尽管事实上，例如，约50%的患者在其治疗过程中将经历分次放射治疗，已知该治疗影响其肿瘤、其脉管系统和紧邻的周围正常组织，所有元素可能反过来影响肿瘤对后续化疗和/或生物制剂的反应。 为了解决这一缺陷，我们的申请要求资金在罗切斯特大学医学中心（URMC）购买用于动物和细胞的精密X射线辐照器/锥形束CT。该仪器是一个小动物辐射研究平台或SARRP，它将满足该机构医学研究的关键需求，因为它将允许Atriatos在临床前模型中评估药剂与现实辐射协议的协同作用，从而真正模拟人类体验。此外，SARRP将与其他最先进的成像设备结合使用，通过允许他们对小动物模型（大鼠和小鼠）进行图像引导照射来扩展研究人员的能力。总的来说，将SARRP添加到罗切斯特大学可用的技术中将增加正常组织和肿瘤组织研究的机会，为研究人员提供更合适的模型系统，用于评估肿瘤-正常组织微环境、许多癌症患者中观察到的正常组织效应和良性疾病。

项目成果

Prevention of Radiation-Induced Bladder Injury: A Murine Study Using Captopril.

预防辐射引起的膀胱损伤：使用卡托普利的小鼠研究。

• DOI: 10.1016/j.ijrobp.2022.10.033
• 发表时间: 2023
• 期刊: International journal of radiation oncology, biology, physics
• 作者: Groves,AngelaM;Paris,Nicole;Hernady,Eric;Johnston,CarlJ;Aljitawi,Omar;Lee,Yi-Fen;Kerns,SarahL;Marples,Brian
• 通讯作者: Marples,Brian