Translational, multimodality correlation between human and rabbit saccular aneurysms

 描述(由申请人提供)：该研究计划的长期目标是改善对存在未破裂的颅内动脉瘤的患者的护理。这些动脉瘤出现在大约2%的人群中，由于MRI和CT扫描的广泛使用，被诊断的频率越来越高，可能会发生自发性破裂，造成毁灭性的后果。然而，一旦发现，治疗的决定必须在自发性破裂的风险和治疗风险之间进行权衡。动脉瘤破裂的年度风险很低，但记录准确破裂比率的高质量研究相对较少。此外，即使使用最先进的治疗技术，每20名患者中也有一人会因治疗本身而患上神经系统疾病。不幸的是，可能澄清这些不确定性的临床和尸检数据仍然难以捉摸。为了改善这些患者的预后，许多组织正在探索破裂风险和治疗结果的替代标记物的预测价值。这些方法包括对几何和其他特征的详细分析，这些特征将用于计算建模以预测破裂风险，以及开发创新的微创疗法。囊状动脉瘤的动物模型是这些研究假设和临床之间的桥梁，将新的想法转化为临床实施。这项拟议的工作将首先证实，该动物模型准确地模拟了实际人类动脉瘤组织的病理、生物学和机械结构。该项目将使治疗前后的颅内动脉瘤患者受益，其长期目标是减少或消除毁灭性动脉瘤破裂的风险。

 DESCRIPTION (provided by applicant): The long term objective of this research program is to improve the care of patients harboring unruptured, intracranial aneurysms. These aneurysms, present in approximately 2% of the population and being diagnosed with increasing frequency because of widespread use of MRI and CT scanning, may undergo spontaneous rupture with devastating consequences. Once discovered, however, the decision to treat must balance the risk of spontaneous rupture against the treatment risk. The annual risk of aneurysm rupture is low, but there are relatively few high quality studies documenting precise rates of rupture. Furthermore, even with the most advanced treatment techniques, one in twenty patients will suffer from neurologic morbidity from the therapy itself. Unfortunately, clinical and autopsy data that might clarify these uncertainties remain elusive. In an attempt to improve outcomes in these patients, numerous groups are exploring the predictive value of surrogate markers of rupture risk and treatment outcome. These approaches include detailed analysis of geometric and other features to be used in computational modeling for prediction of rupture risk as well as the development of innovative, minimally invasive therapies. Animal models of saccular aneurysms serve as bridge between these research hypotheses and the clinic, translating new ideas to clinical implementation. The proposed work will first confirm that the animal model accurately mimics the pathology, biology, and mechanical structure of actual human aneurysm tissue. This project will benefit patients suffering from intracranial aneurysms, both before and after treatment, with the long term goal of diminishing or eradicating the risk of devastating aneurysm rupture.