RGR-based motion tracking for real-time adaptive MR imaging and spectroscopy

描述(由申请人提供)：这是1R01 DA21146-01的续签申请，这是一个生物工程研究伙伴(BRP)开发MRI实时预期运动矫正(PMC)的申请。磁共振成像(MRI)是一种在活体内评估人脑结构、功能和生理的强大技术。MRI提供了高空间和时间分辨率，是非侵入性的和可重复的，可以在儿童身上进行。然而，在许多MR研究中，运动仍然是一个严重的问题，特别是那些在儿童、婴儿或因焦虑、药物使用或疾病而焦虑或困惑的受试者身上进行的研究，导致数据中存在运动伪影，这可能会阻碍准确的诊断或评估。预期运动校正可以通过在扫描期间动态跟踪头部/大脑的运动，并持续校正采集，从而使它们相对于移动的大脑锁定，从而显著减弱运动伪影。在最初的项目期间， 我们在开发基于光学的MRI运动跟踪和校正方面取得了实质性进展。虽然最初的原型系统在相对较小和较慢的运动中表现良好，但在临床相关运动(更大的幅度和更高的速度)期间，系统可能无法充分减弱运动伪影。拟议的竞争更新将侧重于解决这些问题，具体目标如下。(1)提高光学跟踪运动校正的稳健性。(2)开发更高速度(高达100 mm/S和�/S)的运动校正技术，并对一组临床相关序列实施这些方法。(3)开发头部运动过程中数据的重建技术。(4)验证了所开发的运动矫正方法的临床有效性和实用性。这项工作将由一个经验丰富的调查团队进行，他们有合作的记录，使用现代3T和7T扫描仪。实施这些创新将增加自适应运动矫正技术在临床领域的可用性，并有望改进和提高儿童和患者的磁共振扫描，这些患者在研究和临床环境中都难以保持静止。

DESCRIPTION (provided by applicant): This is a renewal application for 1R01 DA21146-01, a Bioengineering Research Partnership (BRP) to develop real-time prospective motion correction (PMC) for MRI. Magnetic resonance imaging (MRI) is a powerful technique for assessing the structure, function, and physiology of the human brain in vivo. MRI affords high spatial and temporal resolution, is non-invasive and repeatable, and may be performed in children. However, motion continues to be a substantial problem in many MR studies, especially those performed in children, infants, or subjects who are agitated or confused due to anxiety, drug use or sickness, resulting in data with motion artifacts that may prevent accurate diagnoses or assessments. Prospective motion correction can dramatically attenuate motion artifacts by dynamically tracking the motion of the head/brain during a scan, and continuously correcting acquisitions such that they are locked relative to the moving brain. In the initial project period, we made substantial progress in developing optical-based motion tracking and correction for MRI. While the initial prototype system performs well for relatively small and slow movements, the system may fail to sufficiently attenuate motion artifacts during clinically relevant motions (larger amplitudes and higher speed). The proposed competitive renewal will focus on resolving these issues, with the following specific Aims. (1) Improve robustness of motion correction with optical tracking. (2) Develop techniques for motion correction at higher velocities (up to 100mm/s and �/s), and implement these methods for a set of clinically relevant sequences. (3) Develop reconstruction techniques for data acquired during head motion. (4) Demonstrate clinical efficacy and utility of the motion correction methods developed. The work will be performed by an experienced team of investigators with a track record of collaboration, using modern 3T and 7T scanners. Implementing these innovations will increase the availability of adaptive motion correction technologies for the clinical arena, and promise improved and more robust MR scans in children and patients who have difficulty holding still, both in research and clinical settings.