ISU-Vet-LRN Cooperative Agreement Proposal

项目摘要 拟议的工作是为爱荷华州州立大学兽医诊断 实验室（ISU VDL）和FDA兽医中心Vet-LRN在三个方面提供支持： a）在发生大规模动物疾病时，为诊断目的对兽医诊断样本进行检测。 样品可以是动物食品/饲料/药品以及与饲料/食品/药品生产相关的环境样品 和/或联邦、州和地方机构根据 协调FDA VPO; B）为监管目的提供分析支持，包括能力验证， 提高兽医诊断实验室检测结果的质量;以及c）参与方法 开发和验证以及矩阵扩展。 ISU VDL是由AAVLD认证的全方位服务的实验室，提供尖端的诊断 为爱荷华州及其他地区提供服务。ISU VDL的案件负载在全国是独一无二的，因为它是 主要与食用动物有关。实验室不仅是食品安全领域的第一道防线 全国各地的食用动物生产者，而且还大力从事保护宠物动物健康。这 该项目将专门处理与化学污染导致动物疾病或死亡有关的问题。 我们大量的食用动物产品出口到海外的欧盟和亚洲市场， 对食品安全敏感。参与这项合作协议计划也将有利于FDA，实验室 和爱荷华州，因为该项目的所有方面都为我们的产品增加了价值-即及时和可靠 结果 ISU VDL配备了良好的设备和人员，可以积极影响FOA中概述的FDA的需求。 具体来说，我们拥有必要的基础设施，可以使用 动物或环境样本，并协助FDA开发和验证基于组织或 动物药物作为粮食紧急反应网络的成员和长期参与者， 作为Vet-LRN的创始成员，我们拥有准确报告结果的基础设施 而且高效。我们的工作产品的质量由独立的质量保证部门监督。在 总而言之，我们有资源和基础设施来及时交付我们的工作产品。

PROJECT SUMMARY The proposed work is for a cooperative agreement between Iowa State University Veterinary Diagnostic Laboratory (ISU VDL) and the FDA Center for Veterinary Medicine Vet-LRN to provide support in three areas: a) testing of veterinary diagnostic samples in the event of large scale animal illnesses for diagnostic purposes. The samples could be animal food/feed/drugs and environmental samples related to feed/food/drug production and/or animal diagnostic necropsy or clinical samples collected by Federal, State, and Local agencies under the coordination of the FDA VPO; b) analytical support for regulatory purposes, including proficiency testing to enhance the quality of test results from veterinary diagnostic laboratories; and c) participation in method development and validation, and matrix extension. The ISU VDL is a full service fully accredited laboratory by the AAVLD which provides cutting edge diagnostic services to the State of Iowa and beyond. The case load at the ISU VDL is unique in the nation because it is predominantly food-animal related. The laboratory is not only the first line of defense in the area of food safety to food animal producers across the country, but also heavily engaged in protection of pet animal health. This project will specifically address issues related to chemical contamination leading to animal illnesses or death. A significant amount of our food animal products are exported overseas to the EU and Asia, markets that are sensitive to food safety. Participation in this cooperative agreement program will also benefit the FDA, the lab and the State of Iowa as all aspects of this project add value to our product-namely, timely and reliable results. The ISU VDL is well equipped and staffed to positively impact the needs of the FDA as outlined in the FOA. Specifically, we have the necessary infrastructure to quickly and accurately diagnose intoxications using animal or environmental samples, and to assist the FDA to develop and validate new tests based on tissues or animal medications. As members and long-term participants in the Food Emergency Response Network (FERN) and also as founding members of Vet-LRN, we have the infrastructure to report out results accurately and efficiently. The quality of our work product is overseen by an independent Quality Assurance Unit. In summary, we have the resources and infrastructure to deliver our work product in a timely manner.