ISU Vet-LIRN Collaborative Validation of Testing Methods on Animal Diagnostic Spe

ISU Vet-LIRN 合作验证动物诊断特异性测试方法

• 批准号: 8907780
• 负责人: WILSON Kiiza RUMBEIHA
• 金额: $ 9.9万
• 依托单位: IOWA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8907780
• 关键词: ISU; Vet; LIRN; Collaborative; Validation

PROJECT SUMMARY The proposed work is for a cooperative agreement between Iowa State University Veterinary Diagnostic Laboratory (ISU VDL) and the FDA Center for Veterinary Medicine Vet-LIRN. The FDA is lacking validated analytical methods for qualitative and quantitative measurement of chemicals and chemical residues in samples derived from dead or sickened animals. The ISU VDL toxicology and Nutrition Section will collaborate with select sister Vet-LIRN labs across the country to validate analytical methods to meet purposes of this agreement. The ISU VDL is a full service laboratory fully accredited by the AAVLD. We provide cutting edge diagnostic services to the State of Iowa and beyond. It is a key lab in the intensely agricultural North-central AAVLD region. The case load at the ISU VDL is unique in the nation because it is predominantly food-animal related and we have an excellent reputation in the area of diagnosis of animal feed contaminants and toxicants in animal tissues, milk and eggs. The laboratory is not only the first line of defense in the area of food safety to food animal producers across the country, but also heavily engaged in protection of pet animal health. The ISU VDL toxicology section currently offers a suite of validated tests of feed/food borne toxins in feeds and tissues of animal origin including stomach/rumen contents, liver, kidney, fat, milk and/or eggs. For purposes of this cooperative agreement, the ISU VDL will work with select Vet-LIRN labs to help them validate tests for which our lab has a unique expertise in including aflatoxins, Ractopamine, ionophores, ergot alkaloids, bromethalin, Cholecalciferol, selenium, coumesterol, zearalenone and cyanotoxins. In addition we agree to validate in our lab tests in which other labs have the most expertise. Deliverables will include validated methods from our lab to collaborating Vet-LIRN labs and validation reports of methods initiated from our laboratory, training of technicians from other Vet-LIRN labs to become proficient in our methods, and timely completion of analytical tasks initiated by sister labs. The ISU VDL is well equipped and staffed to positively impact the needs of the FDA as outlined in the FOA PA- 13-244. As members and long-term participants in the Food Emergency Response Network (FERN) and also as founding members of Vet-LIRN, we have the infrastructure to report out results timely, accurately and efficiently. The quality of our work product is overseen by an independent Quality Assurance Unit.

项目摘要 拟议的工作是为爱荷华州州立大学兽医诊断 实验室（ISU VDL）和FDA兽医中心Vet-LIRN。FDA缺乏有效的 化学品和化学残留物的定性和定量测量分析方法 来自死亡或患病动物的样本。ISU VDL毒理学和营养科将与 与全国各地精选的Vet-LIRN姐妹实验室合作，验证分析方法，以满足 协议 ISU VDL是一个由AAVLD完全认可的全方位服务实验室。我们提供最先进的诊断 为爱荷华州及其他地区提供服务。它是农业密集的中北部AAVLD的重点实验室 地区ISU VDL的病例负荷在全国是独一无二的，因为它主要与食用动物有关 我们在动物饲料污染物和有毒物质的诊断领域享有盛誉， 动物组织、牛奶和鸡蛋。实验室不仅是食品安全领域的第一道防线， 全国各地的食用动物生产者，而且还大力从事保护宠物动物健康。执行支助股 VDL毒理学部门目前提供一套经验证的饲料和组织中饲料/食源性毒素的测试 动物源性，包括胃/瘤胃内容物、肝脏、肾脏、脂肪、牛奶和/或鸡蛋。对于本 根据合作协议，ISU VDL将与选定的Vet-LIRN实验室合作，帮助他们验证测试， 我们的实验室在包括黄曲霉毒素，莱克多巴胺，离子载体，麦角生物碱，溴杀灵， 胆钙化醇、硒、香豆甾醇、玉米赤霉烯酮和蓝藻毒素。此外，我们同意在我们的 其他实验室最擅长的实验室测试。可验证的方法将包括我们实验室的验证方法 合作Vet-LIRN实验室和我们实验室发起的方法验证报告， 其他Vet-LIRN实验室的技术人员熟练掌握我们的方法，并及时完成分析 由姐妹实验室发起的任务。 ISU VDL设备齐全，人员配备齐全，能够积极满足FOA PA中概述的FDA需求- 13-244.作为粮食紧急反应网络的成员和长期参与者， 作为Vet-LIRN的创始成员，我们拥有及时、准确、 有效地我们的工作产品的质量由独立的质量保证部门监督。