Training Program in the Pathophysiology of Renal Disease

肾脏疾病病理生理学培训计划

• 批准号: 9094723
• 负责人: JOHN M. ARTHUR
• 金额: $ 13.62万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9094723
• 关键词: Functional disorder; Kidney Diseases; Training Programs

DESCRIPTION (provided by applicant): Continuation of an institutional Training Program in the Pathophysiology of Renal Diseases is proposed for postdoctoral MDs recruited after internal medicine residency program or PhDs. The goals of this training program are to train physicians and PhD scientists in four areas of renal research including i) acute kidney injury, ii) cardiovascular risk of chronic kidney disease, iii) basic science aspects of renal transplantation and iv) new therapies for diabetic nephropathy. These areas will provide comprehensive training in basic and clinical translational research. The training program will require a commitment of two years of research funded by the T32 grant followed by one year of clinical training for MDs. During the first year the trainees will have the option to enroll in coursework to earn a Certificae in Clinical and Translational Sciences through the Interdisciplinary Biomedical Sciences (IBS) Graduate Program. The program faculty represents a closely-knit, interactive, multidisciplinary faculty from the Division of Nephrology and Departments of Pharmacology and Toxicology, Microbiology and Immunology, Biochemistry and Molecular Biology, Geriatrics, and Physiology and Biophysics including 9 MDs, 3 MD PhDs, 11 PhDs, and 1 MD MPH. Trainees are expected to master at least one major investigative technique, complete at least one major research project, present their work at a national meeting and apply for NIH funding (K08 award) at the end of their research training. Fellows completing this program will be competitive candidates for academic research careers.

描述（由申请人提供）：继续肾脏疾病病理生理学的机构培训计划是为内科住院医师计划或博士后招募的博士后MD提出的。该培训计划的目标是在肾脏研究的四个领域培训医生和博士科学家，包括i）急性肾损伤，ii）慢性肾脏疾病的心血管风险，iii）肾移植的基础科学方面和iv）糖尿病肾病的新疗法。这些领域将提供基础和临床转化研究的全面培训。该培训计划将需要由T32资助的两年研究承诺，然后是一年的医学博士临床培训。在第一年，学员将可以选择参加课程，通过跨学科生物医学科学（IBS）研究生课程获得临床和转化科学证书。该计划的教师代表了肾脏科和药理学和毒理学，微生物学和免疫学，生物化学和分子生物学，老年医学，生理学和生物物理学部门的紧密联系，互动，多学科的教师，包括9个MD，3个MD博士，11个博士和1个MD MPH。受训者应掌握至少一种主要的调查技术，完成至少一个主要的研究项目，在全国会议上介绍他们的工作，并在研究培训结束时申请NIH资助（K08奖）。完成该计划的研究员将成为学术研究生涯的竞争力候选人。

项目成果

Metal deposition in calcific uremic arteriolopathy.

• DOI: 10.1016/j.jaad.2009.01.042
• 发表时间: 2009-07
• 期刊: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
• 影响因子: 13.8
• 作者: Amuluru, Lavanya;High, Whitney;Hiatt, Kim M.;Ranville, James;Shah, Sudhir V.;Malik, Bilal;Swaminathan, Sundararaman
• 通讯作者: Swaminathan, Sundararaman

Renal Mitochondrial Lipid Peroxidation during Sepsis.

脓毒症期间的肾线粒体脂质过氧化。

• DOI: 10.4172/jok.1000116
• 发表时间: 2016
• 期刊: Journal of kidney
• 作者: Singh,P;Parajuli,N;Mayeux,PR;MacMillan-Crow,LA
• 通讯作者: MacMillan-Crow,LA

Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis?

• DOI: 10.1152/ajprenal.00435.2012
• 发表时间: 2013-02-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
• 影响因子: 4.2
• 作者: Parajuli, Nirmala;MacMillan-Crow, Lee Ann
• 通讯作者: MacMillan-Crow, Lee Ann

Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury.

• DOI: 10.1371/journal.pone.0140025
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Chandrika BB;Yang C;Ou Y;Feng X;Muhoza D;Holmes AF;Theus S;Deshmukh S;Haun RS;Kaushal GP
• 通讯作者: Kaushal GP

Cold Storage Exacerbates Renal and Mitochondrial Dysfunction Following Transplantation.

冷藏会加剧移植后的肾脏和线粒体功能障碍。

• 发表时间: 2016
• 期刊: Journal of kidney
• 作者: Shrum,S;MacMillan-Crow,LA;Parajuli,N
• 通讯作者: Parajuli,N