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Eosinophil trafficking and chronic tissue damage induced by allergic inflammation

Eosinophil trafficking and chronic tissue damage induced by allergic inflammation
过敏性炎症引起的嗜酸性粒细胞运输和慢性组织损伤
批准号：
8975107
负责人：
DAVID H BROIDE
金额：
$40.24万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
项目状态：
已结题
起止时间：
1996-04-01 至 2017-11-30
来源：
https://reporter.nih.gov/project-details/8975107
关键词：
AcuteAdhesionsAllergensAllergic inflammationApplications GrantsAreaAsthmaBone MarrowBreathingChronicDiseaseEndothelial CellsFibroblastsFibrosisGene ProteinsInflammatoryKnock-outLungMatrilysinMediatingPathway interactionsPermeabilityPropertyProtein IsoformsProteomicsReagentSignal TransductionSpecimenTissuesTransgenic MiceTranslatingVascular Endothelial Growth Factorsabstractingangiogenesischromosome 1 lossdifferential expressioneosinophilhuman subjectinnovationmembernovelprogenitortrafficking

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中文摘要
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英文摘要
C. ABSTRACT OF PLANNED BODY OF WORK We plan to continue our studies of angiogenesis and remodeling in eosinophil associated diseases. Areas of innovation: The studies investigate novel pathways that are unexplored in mediating allergen induced remodeling (including Del-1 interacting with VEGF; MMP-7; trafficking of endothelial and fibroblast progenitors), use novel reagents (endothelial cell specific knockout of Del-1; Tie GFP and Col-1 GFP transgenic mice to track endothelial and fibroblast progenitors), and discovery approaches (proteomics, microarray) to identify differentially expressed genes/proteins in chronic vs acute allergen challenged lung (identified several candidates including Wnt signaling member Kremin; miRNA376b). In addition the availability of specimens from asthma and EE allow the findings to be translated to human subjects with remodeling.
期刊论文(4)
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会议论文
T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts.
DOI： 10.4049/jimmunol.1200850
发表时间： 2012-08-15
期刊： Journal of immunology (Baltimore, Md. : 1950)
影响因子： --
作者： [Oseroff C, Sidney J, Vita R, Tripple V, McKinney DM, Southwood S, Brodie TM, Sallusto F, Grey H, Alam R, Broide D, Greenbaum JA, Kolla R, Peters B, Sette A]
通讯作者： Sette A
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function.
DOI： 10.1007/s00109-012-0986-9
发表时间： 2013-05
期刊： JOURNAL OF MOLECULAR MEDICINE-JMM
影响因子： 4.7
作者： [Alexander, Laura E. Crotty, Akong-Moore, Kathryn, Feldstein, Stephanie, Johansson, Per, Anh Nguyen, McEachern, Elisa K., Nicatia, Shari, Cowburn, Andrew S., Olson, Joshua, Cho, Jae Youn, Isaacs, Hart, Jr., Johnson, Randall S., Broide, David H., Nizet, Victor]
通讯作者： Nizet, Victor
Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production.
DOI： 10.4049/jimmunol.1200694
发表时间： 2012-07-15
期刊： Journal of immunology (Baltimore, Md. : 1950)
影响因子： --
作者： [Oseroff C, Sidney J, Tripple V, Grey H, Wood R, Broide DH, Greenbaum J, Kolla R, Peters B, Pomés A, Sette A]
通讯作者： Sette A
Targeting lipid rafts for treatment of asthma
  • 批准号：
    10697410
  • 项目类别：
  • 资助金额：
    $100.0万
  • 财政年份：
    2019
  • 负责人：
    DAVID H BROIDE
  • 依托单位：
    RAFT PHARMACEUTICALS, LLC
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